So excited and glad to get this work out, the culmination of many years of effort and headscratching...just in time for the summer break. 1/n www.biorxiv.org/content/10.6...

CNIH3 is a molecular signature of slow AMPA receptors

At excitatory synapses, glutamate activates receptors in the postsynaptic membrane including the AMPA receptor. Usually considered to be the fastest receptor in the brain, AMPA receptors can produce m...

biorxiv.org

Institut Pasteur researchers developed "optonanobody": a light-controlled nanobody targeting α7 nicotinic receptors. Switch receptors on/off with light, no genetic editing needed. New research tool for Alzheimer's, Parkinson's & schizophrenia. #Neuroscience ↘️ pubs.acs.org/doi/10.1021/...

An Optonanobody for Reversible Photoactivation of Recombinant and Native α7 Nicotinic Receptors

Photopharmacology, which enables the precise optical control of endogenous receptor activity, represents a powerful approach in neuroscience. However, photochromic diffusible ligands often exhibit lim...

pubs.acs.org

FENS promotion! If you order an RWD R821 fiber photometry system from Aquineuro during FENS, we'll take off 15% and include a free fiber holder and 2 boxes of fibers. To read more about the fiber photometry system, visit our website: aquineuro.eu/produits/fib...

Check out in particular our posters on brain-machine interfacing and mouse upper-limb prostheses on Tuesday morning; my work with James Poulet on sensorimotor integration in forelimb M1 with membrane potential recordings on Wednesday afternoon, and more amazing somatosensory-motor work on Thursday!

Sensori-motor Integration and Plasticity Lab@touchmovelab.bsky.social · last mo.

FENS 2026: We will present our BMI, mouse neuroprosthesis and somatosensory processing work through this week, including chairing a session on circuit neuroscience in freely moving mice! Check out the schedule below 🔽🔽🔽

Heading to #FENS2026! First step: 6h50 of train to Bracelona. Please go check the team posters tomorrow morning 👇. I will talk in the photopharmacology session Friday morning. Looking forward to meeting the Neuroscience community !

I am hiring a postdoc to work with me on my ERC Starting Grant project DeMARRe - investigating whether exploration or risk-taking in adolescence influence neural circuit development to calibrate psychiatric vulnerability and resilience in adulthood. Details and application at the link below ⬇️

Less than two weeks to register for the ion channel meeting. Please RT!

Laetitia Mony@laetitiamony.bsky.social · 2mo ago

Only 2.5 weeks left to register to the Ion Channel meeting that will take place in September in Sète (France)! Whether you want to connect with the #Ionchannel community or extend your summer on the Mediterrean sea (or both!), this conference is for you. Registration deadline July 3rd. Pls share!

J’essaye de combiner jury de concours, corrections du manuscrit de thèse de ma doctorante et préparation d’oral pour un grant, tout en recevant un milliard de notifications de l’école des enfants sur la canicule. Illustration fidèle de mon état du moment 👇

Only 2.5 weeks left to register to the Ion Channel meeting that will take place in September in Sète (France)! Whether you want to connect with the #Ionchannel community or extend your summer on the Mediterrean sea (or both!), this conference is for you. Registration deadline July 3rd. Pls share!

🥁Out on @elife.bsky.social 👉Multiple functions of cerebello-thalamic neurons in learning and offline consolidation of a motor skill in mice 🔗 elifesciences.org/articles/102... 👏Congratulations to Andrés Varani, Clément Léna, Daniela Popa and all authors!

Conférence ReSo à Montpellier Jérémie Naudé, chercheur CNRS en neurosciences computationnelles à l'Institut de génomique fonctionnelle de Montpellier, s'intéresse aux discours qui, depuis plus d'un siècle, habillent les préjugés de race et de sexe en résultats scientifiques.

🎓 Pour la première fois, l’École normale supérieure, avec l’ENS Paris-Saclay, l’ENS de Lyon et l’ENS Rennes, met en ligne des vidéos de reconstitution d’épreuves orales de ses concours d’accès. 🎥 Retrouvez toutes les vidéos : https://youtube.pulse.ly/lzwzlknorx

One week to go until the registration deadline. We still have a few spots left. Please apply and join us in Berlin! More details at the link: www.biologie.hu-berlin.de/en/groupsite...

Andrew Plested@andrewplested.bsky.social · 3mo ago

Very pleased to announce the 3rd Berlin Single Molecule Biophysics Course, this September 14th-18th. We now include more single molecule microscopy, with @ewerslab.bsky.social and Maximillian Ulbrich joining Jelena Baranovic and Claudio Grosman as tutors. Apply @ bsmbc@icloud.com by 12th June!

Beautiful and chaotic skies in Paris, with a blinking Eiffel Tower

Funny how, while casually scrolling, I just read « D112 ». I immediately thought : « D112? Is it about Hv1 ? ». And yes, it is about Hv1.

Journal of General Physiology@jgp.org · 2mo ago

Adam Feher, Zoltan Varga et al. examine the molecular mechanism of NZ-58, a novel hHv1 inhibitor. Their findings suggest that it binds to the upper gating triad containing countercharges D112 and D185, leading to a “kinetic trapping” mechanism of inhibition. rupress.org/jgp/article/... #IonChannels

I'm very happy to announce that the "From Postdoc to PI Session" will be sponsored by the @biologists.bsky.social and we will be offering a $$ Prize to the best talk, so now a twofer reason to apply! www.germanfishmeeting.org/from-postoc-... Let me know if you have any question/s! 🐟

From Postoc to PI Session | German Fish Meeting

germanfishmeeting.org

Explore AMPAR-TARP structures in the cerebellum and discover how they mediate high-frequency signals and calcium transients! 🧠 PMID:41379938, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.aeb3577 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Out today! A truly team effort and one of my favorite lab projects The findings connect NMDA/Grin2A malfunction to dopamine dynamics and related behaviors, and provide a futuristic model to develop and test "course altering" treatments for schizophrenia www.nature.com/articles/s41...

Grin2a knockout in adolescent dopamine neurons disrupts prediction error signaling and produces a phenotype relevant to schizophrenia - Molecular Psychiatry

Molecular Psychiatry - Grin2a knockout in adolescent dopamine neurons disrupts prediction error signaling and produces a phenotype relevant to schizophrenia

nature.com

Les Highlights de la Société des Neurosciences sont en ligne, de la neuro à tous les niveaux : de l'épigénétique dans Huntington au réseau de communications ultrasonores des souris africaines; des astrocytes striataux à la mémoire sous endocannabinoïdes. www.neurosciences.asso.fr/wp-content/u...

You know GABA as an inhibitor, but that’s not all! We found that tonic GABAergic signaling, mediated by SST-interneurons and alpha5-type receptors, paradoxically facilitates dendritic calcium signals! www.sciencedirect.com/science/arti...

SST interneurons facilitate dendritic calcium signaling via tonic activation of α5-GABA receptors

Brain activity is highly regulated by GABAergic activity, which can suppress neuronal excitability and synaptic integration. Tonic GABAergic conductan…

sciencedirect.com

La rue du Docteur Roux, #paris15, débute boulevard Pasteur, et se termine rue des Volontaires. Au 11 se trouve l'entrée principale de l'église Saint-Jean-Baptiste-de-La-Salle. Aux 25-28 : institut Pasteur et musée Pasteur. ⤵️

Very pleased to announce the 3rd Berlin Single Molecule Biophysics Course, this September 14th-18th. We now include more single molecule microscopy, with @ewerslab.bsky.social and Maximillian Ulbrich joining Jelena Baranovic and Claudio Grosman as tutors. Apply @ bsmbc@icloud.com by 12th June!

Join us for the next SGP EpIC Seminar on Tuesday, 5 May 2026, at 12:00 pm Eastern featuring a talk by @lauriepeverini.bsky.social on “Protein semi-synthesis uncovers NaV1.5 intracellular conformational landscape & regulation.” As ever, registration is free and all are welcome. sgp-epic-seminars.com

A big step forward in Photopharmacology, just published in Nature Medicine: nature.com/articles/s41... A compound we conceptualized in 2008 (PMCID: PMC4040390) and synthesized in 2010 (PMCID: PMC3401033) proves effective in human vision restoration.

Intravitreal photoswitch therapy in advanced retinitis pigmentosa: a phase 1 open-label trial - Nature Medicine

A first-in-human phase 1 trial shows that intravitreal photoswitch therapy can be administered safely in advanced retinitis pigmentosa, with exploratory signals compatible with light responsiveness fo...

nature.com

This is beautiful data. 2p optical reporting of subthreshold voltage, validated with simultaneous patch clamp. www.biorxiv.org/content/10.6... FORCE1s by François St-Pierre's group, with a bunch of great people joining in.

ERC : "We're overwhelmed with funding request, it's becoming unmanageable. We need to find a way to reduce the number of applications." French Government: "You need to go get the money from Europe, you bunch of losers!" 🫣

Excited to share our new study on how the brain generates placebo pain relief! We developed a mouse model that recapitulates key features of human placebo analgesia, then used it to identify causal circuitry. www.sciencedirect.com/science/arti... today.ucsd.edu/story/neurob... 1/n

Neurobiologists Hack Brain Circuits Tied to Placebo Pain Relief

Scientists have identified the brain circuits tied to placebo pain relief. Researchers have known that placebo effects can be a powerful treatment, yet the underlying neurological mechanisms have not ...

today.ucsd.edu

New paper in Nature, @nature.com (go.nature.com/4c4OjCj) : how do social roles emerge in groups of near-identical individuals ? we find that they are neither predetermined nor fixed.

Dopaminergic mechanisms of dynamical social specialization - Nature

Longitudinal tracking of mice reveals that stable, specialized social roles emerge spontaneously within groups during a foraging task, with dopaminergic activity in the ventral tegmental area driving ...

go.nature.com

Where does anti-NMDAR autoimmune encephalitis come from? Our new work suggests that ectopic NMDAR expression in tumors can trigger anti-cancer immunity, and the resulting antibodies may drive encephalitis-like symptoms. A dynamic Janowitz-Furukawa lab collaboration. www.nature.com/articles/s41...

Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity - Nature

NMDAR expression is sufficient to induce B cell recruitment and affinity maturation, resulting in receptor-modulating antibodies that connect anti-cancer immunity and autoimmunity.

nature.com

On vous attend !

Laetitia Mony@laetitiamony.bsky.social · 5mo ago

Ce lundi commence la @semaineducerveau.bsky.social . Jeudi 19 mars de 17h à 19h30, venez à « cerveau en boutique » @psl-univ.bsky.social découvrir les neurosciences auprès de commerçants de la rue Mouffetard! Plus d’infos ici 👉 psl.eu/agenda/cerve...