Tessera
Folgen

Lara Goscé

@laragosce.bsky.social

Assistant Professor in Modelling at LSHTM, TB modeller

5 Posts351 Follower256 Folgt
Katherine Horton@kchorton.bsky.social · 2w ago

Our new paper in @nathealth.nature.com shows that population-level #TB interventions are likely to have more meaningful impact on disease burden than interventions that only reach routinely diagnosed individuals or their households. www.nature.com/articles/s44... 1/7

Global impact and cost-effectiveness of tuberculosis interventions - Nature Health

A modelling analysis at a global scale estimates that three interventions (vaccination, community-wide screening and prison screening programmes) could prevent more than 10% of tuberculosis cases betw...

nature.com

Lara Goscé@laragosce.bsky.social · 2mo ago

Poverty is a major driver of TB.Conditional cash transfers combined with counselling improve pre-treatment loss to follow-up.In this economic analysis our modelling projections show that this intervention is cost-effective and can reduce incidence and mortality. www.sciencedirect.com/science/arti...

Cost-effectiveness of conditional cash transfers with pre- and post-test tuberculosis counselling in South Africa: a modelling analysis

Tuberculosis (TB) disproportionately affects low-income populations due to socioeconomic barriers. Conditional cash transfers (CCTs) are promising str…

sciencedirect.com

Finn McQuaid@cfmcquaid.bsky.social · 9mo ago

@lshtm-tbmod.bsky.social is offering multiple PhD opportunities through MRC LID, deadline 14 Jan. More details: mrc-lid.lshtm.ac.uk/applicants/ Projects include #1 TB & screening #2 TB & climate change #3 TB & vaccines #4 TB & influenza #5 TB & prevention @cmmid-lshtm.bsky.social @lshtm.bsky.social

Information for applicants - MRC London Intercollegiate Doctoral Training Partnership Studentships

MRC LID studentship information for applicants How to Apply Projects Studentship funding Studentship options Studentship...

mrc-lid.lshtm.ac.uk

TB Centre LSHTM@tb-lshtm.bsky.social · 8mo ago

Join us 📆 9 Dec ⏰ 12.45 @tb-lshtm.bsky.social seminar Free & Open to all @kchorton.bsky.social @richardwhite321.bsky.social @reinhouben.bsky.social @dopapus.bsky.social @laragosce.bsky.social @danieljgrint.bsky.social tinyurl.com/2s4y3jcd

Excerpts from Copenhagen: The UNION World Conference on Lung Health 2025

Each year, many LSHTM TB researchers participate in the UNION World Conference on Lung Health, the world's largest conference on TB and lung health. This year, the conference takes place in

tinyurl.com

Richard White@richardwhite321.bsky.social · 8mo ago

Another successful "Intro to TB Modelling" course in Copenhagen at #WLHC2025. Over 70 joined to learn about TB modelling! Followed by the now-traditional TB Modelling and Analysis Consortium social, which was also very well-attended and a lot of fun.

BildBild
Finn McQuaid@cfmcquaid.bsky.social · 9mo ago

Our framework that informed the @who.int TB & climate change policy brief out now in @lancetrespirmed.bsky.social, exploring the intersections and implications of climate change for the TB epidemic. Key message? TB should be considered a climate-sensitive disease www.thelancet.com/journals/lan...

Climate change and tuberculosis: an analytical framework

Climate change is likely to exacerbate a range of determinants that drive tuberculosis, the world's leading cause of death from a single infectious agent. However, tuberculosis is often neglected in w...

thelancet.com

Matthew Saunders@mjsaunder.bsky.social · 9mo ago

“Wow, I saw in the last GTB report undernutrition is much less important for TB than we previously thought” I hear you say… Well, no. We think this is an underestimate, & as much as 28% of TB could be attributable to undernutrition – see our latest comment here: www.thelancet.com/journals/lan...

Tuberculosis and undernutrition: improving estimates to reinforce the policy imperative

Undernutrition is a key driver of the global tuberculosis epidemic, increasing the risk of people developing tuberculosis disease and of poor outcomes in those who do.1 Each year, WHO publishes estima...

thelancet.com

@chaelinkim.bsky.social · 10mo ago

When fluoroquinolone resistance status is unknown, empirical use of BPaLM (adding moxifloxacin to BPaL) is cost-effective as a replacement for BPaL even with high fluoroquinolone resistance levels! 🦠💊 doi.org/10.1371/jour...

Impact of fluoroquinolone resistance on the cost-effectiveness of empiric treatment for multidrug- or rifampicin-resistant tuberculosis

The WHO recommends the bedaquiline, pretomanid, and linezolid (BPaL) regimen with the additional fluoroquinolone antibiotic moxifloxacin (BPaLM) for initial treatment of multidrug- or rifampicin-resis...

doi.org

Katherine Horton@kchorton.bsky.social · 10mo ago

Understanding patterns of #TB exposure and transmission is needed for targeted prevention strategies. In our latest pre-print, @petedodd24.bsky.social and I estimated the proportion of TB exposure to and transmission from sex and age groups for 177 countries. bit.ly/4nbV492

A global analysis of patterns of tuberculosis exposure and transmission

Tuberculosis (TB) is a major public health concern and the leading infectious cause of mortality globally. The disease exhibits strong prevalence patterns by age and sex, but the implications of these...

medrxiv.org

Rein Houben@reinhouben.bsky.social · 10mo ago

In a new preprint (NOT PEER REVIEWED) we continue to explore the challenge of overtreatment in community screening. It seems the benefits of TB treatment far outweigh the harms, especially once we accept that sputum culture is not perfect. Important food for thought. www.medrxiv.org/content/10.1...

Do no harm - re-evaluating the risks of overtreatment in community-wide tuberculosis screening

Background Community-wide screening is a crucial strategy to end tuberculosis (TB), but a common concern is potential harm from overtreatment following false positive diagnoses. However, current refer...

medrxiv.org

Katherine Horton@kchorton.bsky.social · 11mo ago

At a time when global resources for #TB research, development, prevention, and care are limited, which interventions should be prioritised in high burden settings? 📢 Our new pre-print compares the impact, cost, and cost-effectiveness of 9 TB interventions in 3 countries. 1/n bit.ly/3V3vXth

The potential impact, cost and cost-effectiveness of tuberculosis interventions - a modelling exercise

Background While a range of interventions exist for tuberculosis prevention, screening, diagnosis, and treatment, their potential population impact and cost-effectiveness are seldom directly compared,...

bit.ly

Democracy Now!@democracynow.org · last yr.

Secretary of State Marco Rubio has imposed sanctions on Francesca Albanese, the U.N. special rapporteur on the occupied Palestinian territory. Albanese says the move is an effort to “distract” from the genocide in Gaza.

Katherine Horton@kchorton.bsky.social · last yr.

New systematic review led by @hannahrickman.bsky.social shows annual risk of Mycobacterium #tuberculosis conversion in men and women diverges during adolescence and remains higher among men throughout adulthood. www.thelancet.com/journals/lan...

The figure shows two graphs, both with age on the x-axis and separate curves for males and females. In the top figure, the y-axis shows prevalence of Mtb immunoreactivity; in the bottom figure, the y-axis shows annual risk of Mtb conversion. In both figures, the curves for males and females diverge from adolescence and remain higher for men than women through adulthood.
The LIGHT Consortium @lightontb.bsky.social · last yr.

NEW STUDY! 📣 A large global study found men are more likely to be exposed to TB than women. The reason? Likely social behaviours: • More time in crowded indoor spaces • Delays in seeking care READ MORE ⤵️ 🔗 www.thelancet.com/journals/lan... @petermacp.bsky.social @hannahrickman.bsky.social

infographic highlighting the key points from the paper published in the Lancet: Sex differences in the risk of Mycobacterium tuberculosis infection: a systematic review and meta-analysis of population-based immunoreactivity surveys
LSHTM TB Modelling Group@lshtm-tbmod.bsky.social · last yr.

Can you believe it’s already been 25 years!? Come join us on 20 June 2025 at 4pm UK time to celebrate the 25th anniversary of the Introduction to #Infectious Disease #Modelling course delivered by @lshtm.bsky.social and @ukhsa.bsky.social! More info 👉 www.lshtm.ac.uk/newsevents/e...

25th anniversary celebrations of the Introduction to Infectious Disease

Our special event will celebrate the 25th anniversary of the Introduction to Infectious Disease Modelling and its Applications course, delivered by the London School of Hygiene & Tropical Medicine

lshtm.ac.uk

Finn McQuaid@cfmcquaid.bsky.social · last yr.

TB & climate change: @who.int report out now, building on an analytical framework we developed to explore the intersections and implications for the TB epidemic. Key message? TB should be considered a climate-sensitive disease www.who.int/publications...

Tuberculosis and climate change: analytical framework and knowledge gaps

This report explores the intersection of tuberculosis (TB) and climate change, highlighting how climate-related challenges such as food and water insecurity, displacement, and disrupted healthcare acc...

who.int

Rein Houben@reinhouben.bsky.social · last yr.

Amid all the bad news in Global Health, perhaps some good news? A first analysis on the risk of false positive diagnoses in community-screening for tuberculosis using Xpert shows our clinic-based data is likely (very) wrong and overestimates false positives by >80%: tinyurl.com/yfecute9.

Bild
Lara Goscé@laragosce.bsky.social · last yr.

Climate-driven migration and displacement and their potential impact on TB in Latin America gh.bmj.com/content/10/4... @cfmcquaid.bsky.social @reinhouben.bsky.social @lshtm-tbmod.bsky.social

Tuberculosis and the climate crisis in Latin America: a predicament of poverty, migration and displacement

Tuberculosis (TB) has long been associated with poverty and displacement, through food insecurity, overcrowding, poor living conditions and reduced access to healthcare, which significantly increase t...

gh.bmj.com

Finn McQuaid@cfmcquaid.bsky.social · last yr.

Climate change is likely to exacerbate determinants which drive TB, the world’s leading infectious disease killer. Commissioned by WHO, we developed an analytical framework outlining potential causal relationships between climate change and TB: medrxiv.org/cgi/content/... @lshtm.bsky.social @who.int

Climate change and tuberculosis: an analytical framework

Climate change is likely to exacerbate a range of determinants which drive tuberculosis, the world's leading infectious disease killer. However, tuberculosis is often neglected in wider climate health...

medrxiv.org

Lara Goscé@laragosce.bsky.social · last yr.

Three PhD opportunities in modelling at @lshtm.bsky.social and @ukhsa.bsky.social on: Homelessness/Housing and TB: shorturl.at/FJ57W EBV and cancers in the UK: shorturl.at/IRHJk Climate change and TB: shorturl.at/R7f50

Modelling the cost-effectiveness of Epstein-Barr virus vaccination in England (UKHSA-LSHTM PhD scholarship) at London School of Hygiene & Tropical Medicine on FindAPhD.com

PhD Project - Modelling the cost-effectiveness of Epstein-Barr virus vaccination in England (UKHSA-LSHTM PhD scholarship) at London School of Hygiene & Tropical Medicine, listed on FindAPhD.com

shorturl.at

Alvaro Schwalb@aschwalbc.bsky.social · 2y ago

1/ 📢 In our new PREPRINT - tinyurl.com/2pmudzrk - we evaluate how symptom-agnostic, population-wide screening interventions could significantly reduce the TB burden in Viet Nam. These require a substantial front-loaded investment but yield lasting cost savings. 🧵 #Tuberculosis #TBSky

Potential impact, costs, and benefits of population-wide screening interventions for tuberculosis in Viet Nam: a mathematical modelling study

Background Population-wide screening may accelerate the decline of tuberculosis (TB) incidence, but the optimal screening algorithm and duration must weigh resource considerations. Methods We calibra...

tinyurl.com

Lara Goscé@laragosce.bsky.social · 2y ago

Our ASCENT modelling paper on Digital Adherence Technologies (DAT) for TB treatment is now out in BMJ Global Health gh.bmj.com/content/9/12... DATs may have limited epidemiological impact but can reduce costs and have important budgetary implications. @cfmcquaid.bsky.social @lshtm-tbmod.bsky.social

Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia

Background Digital adherence technologies (DATs) with associated differentiated care are potential tools to improve tuberculosis (TB) treatment outcomes and reduce associated costs for both patients a...

gh.bmj.com