Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis www.biorxiv.org/content/10.1...

Uncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis

Endothelial cells (ECs) are critical regulators of vascular function and exhibit specialized, organ-specific roles across tissues. During aging, these cells become dysfunctional, resulting in increase...

biorxiv.org

🚨Preprint alert!🚨What happens to our blood vessels as we age? To begin answering this at the transcriptome level, we built the Human Aging Endothelial Cell Atlas (HAECA), profiling >375,000 endothelial cells from 12 tissues across adulthood. www.biorxiv.org/content/10.1... (1/9)

#BookSky

"our results indicate that academia pays a price by focusing attention and resources on superstars" Nice to see this supported by data analysis, now. H/T: @cxdig.bsky.social www.nature.com/articles/s41...

The innovation trade-off: how following superstars shapes academic novelty - Humanities and Social Sciences Communications

Humanities and Social Sciences Communications - The innovation trade-off: how following superstars shapes academic novelty

nature.com

🔬 As we near the end of #EquationsForLife, today we spotlight @ar-abdelfattah.bsky.social's Group! They use the #ReactionDiffussion equation to characterize the process of tissue organization and maintenance in physiology, and how disease disrupts it. 🔎 bit.ly/4ef2Pbe

We kicked off the week with Roger Kamm (@mitdeptofbe.bsky.social) for a #CeMMinar on brain neurovascular models & its applications to modeling drug & toxin transport. Thanks to Roger for the great insights & hosts @lderooij.bsky.social & @ar-abdelfattah.bsky.social

A very insightful Impromptu Seminar today at #CeMM by Kumar Sharma (@uthealthsa.bsky.social), hosted by our PI @ar-abdelfattah.bsky.social! His talk on spatial mass spectrometry & precision therapeutics offered powerful insights into disease mechanisms and inter-organ crosstalk. Thank you, Kumar!

🌐 Introducing MOTION WorkPackage 2 by @reibergerthomas.bsky.social 🌐 In this particular WP the team is focusing on decompensated cirrhosis.. #liver #PortalHypertension #clinicaltrails #dACLD 🔽 Find out more in the video below 📷🔽

Let’s kick off the week with #EquationsForLife! @lderooij.bsky.social’s group studies how #aging affects endothelial cells in blood vessels. Using #MurraysLaw & 3D “vessel-on-a-chip” models, they aim to decode & combat cardiovascular aging. 🔍 tinyurl.com/CeMMRR2024-d... #CeMMResearchReport2024

🚨 Exciting Opportunity! 🚨 Join us on June 9th in Brussels for a satellite conference to the 4th MPS World Summit, where we will address advancements & challenges in #aging research using #microphysiological systems and #organoids. Sign up here: lnkd.in/dCu_yCBr

🚨Job alert🚨! We are looking for a highly motivated research technician to join us in our quest to dissect the transcriptomic make-up and function of endothelial cells across the human body, using cutting-edge omics technologies, clinical samples, and vessel-on-chip models. Please share & apply! 👇

Only two weeks left to apply, don't miss out!! 👇

Laura de Rooij@lderooij.bsky.social · 2y ago

Looking for a fully funded PhD position in wonderful Vienna? The CeMM PhD program is now open for applications! 🎓 🥼 🧫 We are seeking passionate and driven students interested in helping us understand #endothelial cell heterogeneity in both healthy and pathological #aging. See below for more info 👇

Excited to share our single-cell study on aging mouse brain! We found 2,449 cell-type specific age-DE genes, and an aging hotspot in specific hypothalamic cell types involved in energy homeostasis, which show both decreased neuronal function and increased immune response. doi.org/10.1038/s415...

Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice - Nature

A comprehensive single-cell RNA sequencing study delineates cell-type-specific transcriptomic changes in the brain associated with normal ageing that will inform the investigation into functional chan...

doi.org

allen institute@alleninstitute.org · 2y ago

New brain aging study is out today in Nature The largest single-cell RNA seq dataset of mouse brain aging reveals incredible insights and could pave the way for future therapies to slow or manage the impacts of the aging process. 🧵 #studyBRAIN

Looking for a fully funded PhD position in wonderful Vienna? The CeMM PhD program is now open for applications! 🎓 🥼 🧫 We are seeking passionate and driven students interested in helping us understand #endothelial cell heterogeneity in both healthy and pathological #aging. See below for more info 👇

Is anyone else just *not interested* in using AI for their writing? All accuracy and morality aside, I just don't want to. I want every last word I put on a page to have flowed out from my own body. Maybe I'm romanticizing it, but I just can't see it any other way.

Our #TBI project got funded! Driven by what happens when forces are too much to handle, we will engineer tools to traumatize organoids and focus on #ECMatrix dynamics, #mechanobiology, and molecular-to-multicellular tissue organization. Happy to collaborate! Happening @ CeMM

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨 We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research! Read more: bmcgenomics.biomedcentral.com/articles/10.... 1/8

High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics

The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...

bmcgenomics.biomedcentral.com

The complications of SARS-CoV-2 infection highlight the key role of #endothelial functions in health and disease. Great perspective in light of acute and Long Covid, and strongly in line with what we previously speculated: doi.org/10.1161/CIRC...

Eric Topol@erictopol.bsky.social · 2y ago

Blood vessel wall (endothelial) inflammation as a key to multi-organ complications of Covid and #LongCovid @science.org science.org/doi/10.1126/...

Blood vessel wall (endothelial) inflammation as a key to multi-organ complications of Covid and #LongCovid @science.org science.org/doi/10.1126/...

Endothelial inflammation in COVID-19

Disrupted endothelial function underlies the multiorgan complications of COVID-19

science.org

The strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on? direct.mit.edu/qss/article/... A 🧵 1/n #AcademicSky #PhDchat #ScientificPublishing #SciPub

Atlas of the plasma proteome in health and disease in 53,026 adults. #Cell #medBsky #SciBsky #scisky #proteome These results provide an open-access comprehensive proteome-phenome resource (proteome-phenome-atlas.com). Open Access www.cell.com/cell/fulltex...

@bioeng-talk.bsky.social is posting here as well! Speaking of moving to new places (🦋), in this episode, a bunch of us discuss why we moved to Europe to continue our academic careers. Tune in to hear about our experiences and what motivated us to make the leap.

BioEngineering Talk Podcast@bioeng-talk.bsky.social · 2y ago

For our first post here 🦋, we discuss why some of us changed environments to pursue science, focusing on career moves that brought us to Europe. Are you planning to move for your next position? Hear us about our experiences, motivations, and the hurdles we faced. t.co/5gRHhw2eef

Updated Aging Starter Pack!! People and labs interested in aging 😀 Let me know if you'd like to be added! go.bsky.app/5UXXaDA

Let the first post be about our lab website! Happy to announce it's up and running. Our vision of controlling tissue organization and probing its mechanics is rather magnetic 🧲⚙️🧫🧬! #mechanobiology 👉 www.abdelfattahlab.org

Abdel Fattah Lab

abdelfattahlab.org

Excited to join the 🦋 community, and even more excited to share that the lab has its very own logo & website! 🖥️🔎 Visit us at derooijlab.org to explore our work, stay updated on ongoing projects, papers, and more!