LEK Lab
@lek-lab.bsky.social
Laboratory of Prof. Lewis E. Kay at the University of Toronto | Nuclear Magnetic Resonance of biomolecules | Est. 1992
Really excited to have my work on the Caspase-11 non-canonical Inflammasome complex published today in @pnas.org! Check it out below 👇 www.pnas.org/doi/10.1073/...
The dynamic and heterogeneous structure of the non-canonical inflammasome | PNAS
Inflammasomes are high-molecular-weight complexes that play integral roles in the innate immune system, triggering an inflammatory cascade to prote...
pnas.org
Professor Lewis E. Kay @lek-lab.bsky.social University of Toronto/SickKids, has been promoted to Companion of the Order of Canada, the highest level of the Order of Canada, for his pioneering biomolecular NMR research, and training a new generation of scientists www.gg.ca/en/appointme... #NMRchat 🧲
Order of Canada Appointees – June 26, 2026
Companions Michael Andrew Fox, C.C. Burnaby, British Columbia and New York, New York, United States of America
gg.ca
The dynamic and heterogeneous structure of the non-canonical inflammasome https://www.biorxiv.org/content/10.64898/2026.04.15.718739v1
Jeff & Co. Just finished cooking this up. Give it a read! 👇👇👇👇 www.biorxiv.org/content/10.1...
Making invisible excited state protein structures visible by combining NMR and machine learning
NMR relaxation studies of the precursor form of the pro-inflammatory cytokine interleukin-18, pro-IL-18, show that it adopts two sparsely populated (<0.5%) and transiently formed (ms lifetimes) excite...
biorxiv.org
ICYMI: New Online! The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance
The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance
Nature Reviews Molecular Cell Biology, Published online: 20 November 2025; doi:10.1038/s41580-025-00897-2Biomolecular condensates are non-membrane-encapsulated compartments that control various biological processes. Recent studies have revealed that condensates change in response to stimuli and over time. This Review discusses the heterogeneity and composition changes of nuclear and cytoplasmic condensates, their regulation and how the changes affect cellular biochemical reactions.
bit.ly
New Online! The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance
The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance
Nature Reviews Molecular Cell Biology, Published online: 20 November 2025; doi:10.1038/s41580-025-00897-2Biomolecular condensates are non-membrane-encapsulated compartments that control various biological processes. Recent studies have revealed that condensates change in response to stimuli and over time. This Review discusses the heterogeneity and composition changes of nuclear and cytoplasmic condensates, their regulation and how the changes affect cellular biochemical reactions.
bit.ly
Solution NMR goes big: Atomic resolution studies of protein components of molecular machines and phase-separated condensates, Alexander I.M. Sever, Rashik Ahmed, Philip Rößler, Lewis E. Kay* @lek-lab.bsky.social @utoronto.ca www.sciencedirect.com/science/arti... #NMRchat 🧲
Solution NMR goes big: Atomic resolution studies of protein components of molecular machines and phase-separated condensates
The tools of structural biology have undergone remarkable advances in the past decade. These include new computational and experimental approaches tha…
sciencedirect.com
Our latest paper is online today ahead of print in PNAS @pnas.org www.pnas.org/doi/10.1073/...
Functional spectrum of USP7 pathogenic variants in Hao–Fountain syndrome: Insights into the enzyme’s activity, stability, and allosteric modulation | PNAS
Hao–Fountain syndrome is a rare neurodevelopmental disorder caused by mutations in the deubiquitinating enzyme Ubiquitin-Specific Protease 7 (USP7)...
pnas.org
The CSC and CSChE societies and communities express deep concern over proposed Tri-Council funding cuts. Canada must invest in science to ensure long-term health, innovation, and prosperity. Read the full statement here: buff.ly/peiCUfk
buff.ly
Journal of Molecular Biology (open) Review Article, Application of NMR to Large RNAs, Brian D. Grossman, Jan Marchant*, Michael F. Summers* www.sciencedirect.com/science/arti... #NMRchat 🧲
Application of NMR to Large RNAs
Heteronuclear NMR methodologies developed over the past 40 years have enabled atomic level insights into the solution-state structure and dynamics of …
sciencedirect.com
New paper from the Gossert lab: Dynamic interactions in the human β1AR signalling complex with mini-Gs revealed by NMR www.sciencedirect.com/science/arti...
Dynamic interactions in the human β1AR signalling complex with mini-Gs revealed by NMR
A wealth of insights into the mechanisms of GPCRs have been gained from biophysical studies of thermostabilized β1 adrenergic receptors (β1AR) from tu…
sciencedirect.com
Allosteric regulation of proteolytic machines unveiled by the synergy between cryo-EM and solution NMR spectroscopy pubmed.ncbi.nlm.nih.gov/40857152/ #cryoEM
Get important feedback from your community and move your work forward. Share your research at #bps2026! Submit an abstract today buff.ly/oOjstk6
BPS2026 Annual Meeting | Biophysical Society
The BPS2026 Annual Meeting in San Francisco will showcase Biophysics by the Bay, highlighting the exciting advances in science and technology brought forth by big data and AI. This year’s program…
biophysics.org
How a small lab @cicbiogune.bsky.social led by Óscar Millet, took on one of the world’s rarest diseases www.the-scientist.com/modeling-ang... #NMRnews #NMRchat #NMR 🧲
New paper alert! Stellar work by brilliant lead first author @annaleder.bsky.social together with project leader @masgu.bsky.social reveals a groundbreaking discovery: PDIA6 forms multi-chaperone condensates creating "folding factories" in the ER. www.nature.com/articles/s41...
Nature Communications (open) Seedless: on-the-fly pulse calculation for NMR experiments, Charles J. Buchanan, Gaurav Bhole, Gogulan Karunanithy, Virginia Casablancas-Antràs, Adeline W. J. Poh, Benjamin G. Davis, Jonathan A. Jones* & Andrew J. Baldwin* www.nature.com/articles/s41... #NMRchat #NMR 🧲
Seedless: on-the-fly pulse calculation for NMR experiments - Nature Communications
The authors develop a computational tool to design NMR pulses, based on the GRadient Assisted Pulse Engineering approach, that can calculate optimal pulse shapes on the fly during the measurements, to...
nature.com
#3: #PhD Position on Structure–Dynamics–Function Relationship of the #Chaperone #Hsp90: ➤ NMR spectroscopy for atomic-resolution ➤ Single-molecule FRET for time-resolved dynamics Collab.: @hillerlab.bsky.social & Schmid lab @unibas.ch More info & online application system: tinyurl.com/mr2em3nk
💥 We have 3 positions open in my lab in Basel, Switzerland🇨🇭: #nanopores #smFRET #biomolecular #dynamics #singleMolecules We’re looking for talented & ambitious new colleagues enthusiastic about biomolecular dynamics & single-molecule tech. Please share broadly, thank you!🤝 schmid.chemie.unibas.ch
Home | Research Group Schmid | University of Basel
schmid.chemie.unibas.ch
on behalf of Professor James Keeler (University of Cambridge) considering the possibility of revising the text and creating a third edition : Understanding NMR Spectroscopy, James Keeler - survey concerning a possible third edition cambridge.eu.qualtrics.com/jfe/form/SV_... #NMRbooks #NMRchat #NMR 🧲
Nature research paper: Diffusing protein binders to intrinsically disordered proteins go.nature.com/4lSCdzE
Diffusing protein binders to intrinsically disordered proteins - Nature
Using RFdiffusion, a general method for targeting intrinsically disordered proteins and regions for protein design has been developed.
go.nature.com
Absolutely outrageous interference in NIH extramural funding by OMB dropping this evening. Damaging to our nation’s world leadership, innovation, and training today and for years in the future. www.wsj.com/politics/pol...
Trump Administration Puts New Chokehold on Billions in Health-Research Funding
The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.
wsj.com
#bioGUNE_Talent | 👏 Óscar Millet #CICbioGUNE @brtaeus.bsky.social, appointed Vice President of @group-ampere.bsky.social, Europe’s top #NMR organization, the first Spanish scientist to hold this role 🎉 Congratulations, Óscar! 🔗 ow.ly/hxi450Wuwiw
Great #NMR work on PTMs of histones by @roesslph.bsky.social and colleagues at @lek-lab.bsky.social!
Philip Rößler@roesslph.bsky.social · last yr.Fresh off the press from the @lek-lab.bsky.social: Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and PARylation #NMRchat www.pnas.org/doi/10.1073/...
I am (optimistically) looking for a postdoc with solution state biomolecular NMR expertise to join our group. I can provide access to high-end instrumentation and technical assistance via our membership at the New York Structural Biology Center. #nmr #academicsky #postdoc
Tenure Track Professor of Structural Biology of Emerging Drug Targets at Medical University of Graz www.medunigraz.at/en/job-openi... #NMRjobs #NMRchat #NMR 🧲
Tenure track professorships
medunigraz.at
New publication alert! Using NMR we show how the C-tail of USP7 contributes to its activation by facilitating ubiquitin release. Online today in Journal of Molecular Biology. www.sciencedirect.com/science/arti...
The C-Terminal Tail of Ubiquitin-Specific Protease 7 Facilitates Ubiquitin Release and Ensures Efficient Catalytic Turnover
USP7 is a key ubiquitin-specific protease involved in human development. Its activity is regulated by an intramolecular interaction between the cataly…
sciencedirect.com
Good heavens. How are we supposed to do NMR when D2O prices are north of $1,500/L?
Please join me and >5000 others in supporting NIH staff in their work supporting US biomedical research! actionnetwork.org/forms/add-na...
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