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Lena Spieth

@lenaspieth.bsky.social

Postdoctoral researcher at DZNE and TU Munich. Glia enthusiast 🧠 lipid lover 🤿 diver.

8 Posts395 Follower75 Folgt
Lena Spieth@lenaspieth.bsky.social · 9mo ago

Our new paper reveals that chronic active MS lesions feature CD8⁺ T cell niches with lipid-laden, inflamed microglia. IFN-γ drives cholesterol buildup, linking dysregulated lipid metabolism to inflammation and meurodeg. Check it out @cp-immunity.bsky.social www.sciencedirect.com/science/arti...

Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions

Compartmentalized inflammation is a key driver of multiple sclerosis (MS) progression, but the mechanisms sustaining its persistence remain unclear. A…

sciencedirect.com

Hauke Werner@myelincentric.bsky.social · 11mo ago

If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed! www.biorxiv.org/content/10.1...

Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system

Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formatio...

biorxiv.org

Lena Spieth@lenaspieth.bsky.social · 2y ago

5FAD transgene parentage influences plaque burden. 🐭 Congratulations @aosasmita.bsky.social, @taisiianazarenko.bsky.social @constanze depp and @Klaus-Armin Nave. Happy to have contributed a little.

Andrew Octavian Sasmita@aosasmita.bsky.social · 2y ago

Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant. Thread below: (1/11)

Janos Groh@janos-groh.bsky.social · 2y ago

How does aging affect the white matter and what are the consequences for brain function and neurodegenerative disease? Thankful to see this review with Mika Simons now published in a fascinating collection on the science of brain aging @cp-neuron.bsky.social www.cell.com/neuron/fullt...

White matter aging and its impact on brain function

Aging leads to a decrease in white matter volume and damage to myelinated axons, contributing to neurodegeneration. Myelin breakdown can trigger inflammation, creating a vicious cycle that causes further damage. Understanding these changes is key to preventing age-related neurodegenerative disease.

cell.com

Sarah Jäkel@sjaekel.bsky.social · 2y ago

Did you ever wonder about the role of oligodendrocytes in Parkinson's disease? Check out our new unsolved mysteries article in collaboration with the Burbulla lab! It is quite certain that a lot of work moves in this direction. journals.plos.org/plosbiology/...

Are oligodendrocytes bystanders or drivers of Parkinson’s disease pathology?

The major pathological feature of Parkinson ‘s disease (PD), the second most common neurodegenerative disease and most common movement disorder, is the predominant degeneration of dopaminergic neurons...

journals.plos.org

Andrew Octavian Sasmita@aosasmita.bsky.social · 2y ago

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩

Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease - Nature Communications

The role of microglia in Alzheimer’s disease is debated. This paper shows that homeostatic microglia seed amyloid plaques in early disease stages and activated microglia compact plaques at later stage...

nature.com