Submicrometre sampling of living cells by macrophages - Nature

Macrophages can sample antigens from living cells through a trogocytosis-like mechanism that routes ingested material away from degradation, a finding that delineates a previously unknown pathway...

nature.com

Flexible ensheathment of axons enables myelination of complex CNS networks - Nature

The rate of axon ensheathment varies within individual myelinating processes, resulting in chains of myelin sheaths connected by bridges consisting of thin cytoplasmic processes that provide&nbsp...

nature.com

Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis - Nature Immunology

Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...

nature.com

TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration - Nature Neuroscience

Zhu et al. find that aging causes region-specific myelin damage in the spinal cord, which is counteracted by enhanced TGFβ signaling in microglia, revealing a protective mechanism for healthy aging.

nature.com

From Myelin Damage to Immune Dysfunction: Unraveling the Aging Brain

Aging is associated with progressive white matter degeneration, which impairs brain structure and function. Defects in myelinating glial cells, combined with chronic neuroinflammation, contr

hubs.ly

Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging - Nature Neuroscience

How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capi...

doi.org

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...

cell.com

Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration - Nature Neuroscience

White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8+ T cell recruitment, myelinated ax...

nature.com

Metabolic reprogramming through histone lactylation in microglia and macrophages recruits CD8+ T lymphocytes and aggravates spinal cord injury

Ge et al. report a maladaptive innate/adaptive immune axis in which CXCR6+CD8+ T cells, recruited by glycolytically reprogrammed microglia/macrophage-derived CXCL16 chemokines, play an important role ...

cell.com

Spatiotemporal Analysis of Remyelination Reveals a Concerted Interferon-Responsive Glial State That Coordinates Immune Infiltration

Remyelination, the process by which axons are re-encased in myelin after injury, is a critical step in restoring brain function, yet the dynamics from initial injury to repair remain poorly characteri...

biorxiv.org

Oligodendrocytes in Alzheimer’s disease pathophysiology - Nature Neuroscience

Emerging evidence highlights the dual role of oligodendrocytes in Alzheimer’s disease, both providing protective mechanisms against the pathology and contributing to its progression.

nature.com

Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease

The 5xFAD transgenic model, popular in Alzheimer’s disease research, exhibits varying cerebral plaque burden depending on the parental source of the transgene. Mice inheriting the transgene paternally...

cell.com

White matter aging and its impact on brain function

Aging leads to a decrease in white matter volume and damage to myelinated axons, contributing to neurodegeneration. Myelin breakdown can trigger inflammation, creating a vicious cycle that causes further damage. Understanding these changes is key to preventing age-related neurodegenerative disease.

cell.com

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing

Nature - A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T...

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