Using fMRI data from 20 mouse models and large human cohorts, a recent study in @natneuro.nature.com identifies two dominant dysconnectivity patterns linked to distinct molecular signatures in #autism. See our summary and perspectives on the latest work from @gozziale.bsky.social lab: rdcu.be/fiSOL

Terrific resource in @nature.com for anyone interested in human brain development: White matter micro- and macrostructure brain charts for the human lifespan 🧪🧠📈 www.nature.com/articles/s41...

White matter micro- and macrostructure brain charts for the human lifespan - Nature

Integration of data representing 35,120 brain scans from diverse global studies enables construction of reference charts that define normative microstructural and macrostructural properties across the...

nature.com

My most recent and biggest work so far is finally out as a preprint! 🧠🧵 *Linking human brain functional connectivity to underlying neurotransmission* doi.org/10.64898/202... 1/n TL;DR below ↓ #neuroskyence #neuroimaging #MedSky #PsySciSky

Catching up on my paper threads 🧵 Here is a perspective from this year, lead-authored by my supervisor, @juergendukart.bsky.social The many-to-many problem of endophenotypes in psychiatry - a biological perspective doi.org/10.1038/s413... #neuroskyence #neuroimaging #MedSky #PsychSciSky 1/n

*Rescuing Twitter Threads* series 2021: This was my first fist-author and MD thesis paper! *Recovery-Associated Resting-State Activity and Connectivity Alterations in Anorexia Nervosa* doi.org/10.1016/j.bp... PDF: leondlotter.de/doc/2021_ANR... 1/n #neuroskyence #neuroimaging #AcademicSky #SciSky

*Rescuing Twitter Threads* series 2023: *Revealing the neurobiology underlying interpersonal neural synchronization with multimodal data fusion* doi.org/10.1016/j.ne... 1/n #neuroskyence #neuroimaging #AcademicSky #SciSky

*Rescuing Twitter threads* series 2024: *Regional patterns of human cortex development correlate with underlying neurobiology* doi.org/10.1038/s414... 1/n #neuroskyence #neuroimaging #AcademicSky #SciSky

Hello Bluesky! Below this post, you will find all my very interesting "new paper" threads. 🤓 Note that some of these are much older than the timestamp because I rescued them from Twitter to make them accessible for everyone.

Despite decades of research there are still no reliable biomarkers for any of the major psychiatric diagnoses. In this now published perspective in Molecular Psychiatry we consolidate evidence from genetics, exposome and neuroimaging research on the potential reasons underlying these failures.

The many-to-many problem of endophenotypes in psychiatry - a biological perspective - Molecular Psychiatry

Molecular Psychiatry - The many-to-many problem of endophenotypes in psychiatry - a biological perspective

nature.com

Ever wondered if your interesting brain-behavior correlation was over- or under-estimated due to head motion, but were afraid to ask? We’ve created a motion impact score for detecting spurious brain-behavior associations, now available in Nature Communications! doi.org/10.1038/s414...

Serious concerns about a new cortical biomarker for pain sensitivity jamanetwork.com/journals/jam... We (with @tspisak.bsky.social, @christianbuchel.bsky.social) published a commentary on Chowdhury, Bi et al. (2025, JAMA Neurology) raising serious concerns about their reported results. 👇 1/13

Concern About Predictive Performance of a Pain Sensitivity Biomarker

To the Editor Chowdhury et al1 evaluated a biomarker for pain sensitivity, combining peak alpha frequency and corticomotor excitability. The authors report outstanding performance (validation set area...

jamanetwork.com

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...

After some time since completing my Master’s thesis, I’m excited to share that our work has now been published! It’s rewarding to see the project come full circle and contribute to the field alongside a fantastic team. You can read the full article here: doi.org/10.1093/brai... Published in Brain 🧠

N-methyl-d-aspartate receptor hypofunction causes recurrent and transient failures of perceptual inference

Perception combines external sensory signals with internal predictions that reflect prior knowledge about the world. Weilnhammer et al. show that the NMDAR

doi.org

Veith Weilnhammer, MD@veithweilnhammer.bsky.social · 2y ago

New paper in @brain1878.bsky.social: Healthy people under S-ketamine, an NMDAR antagonist, and people living with schizophrenia, a disorder associated with NMDAR hypofunction, spend more time in an external mode of perception - where noisy sensory signals override knowledge about the world.

Amazing new paper on individual development of E/I balance during adolescence, first-authored by @amnsbr.bsky.social! Read @ Science Advances: www.science.org/doi/10.1126/... Bonus: Amin developed a tool to run biophysical network modelling on GPUs – because why shouldn't he? cubnm.readthedocs.io

Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling

Individualized simulations reveal a decrease in excitation-inhibition ratio in association areas throughout adolescence.

science.org

Amin Saberi@amnsbr.bsky.social · last yr.

🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence? We asked this in our new paper just out in #ScienceAdvances ✨ “Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling” 📄 www.science.org/doi/full/10.... 🧵⤵️

🚨Preprint!🚨 So excited to share my 1st major study as a postdoc at @holmeslab-bhi.bsky.social!🤘 www.biorxiv.org/content/10.1... Using a transdiagnostic framework, we found that brain network dynamics were able to discriminate individualized psychiatric symptom profiles with high accuracy 🧵1/9👇

When I first started working with resting state fMRI as a postdoc, there was a lot of skepticism about what we could learn from it. 20 years later, it's hard to imagine where the field of neuroscience would be without it. Here's a summary 🧠 www.nature.com/articles/s41...

The history and future of resting-state functional magnetic resonance imaging - Nature

This Review provides an overview of the history of resting-state functional MRI research, which has helped to reveal the spatiotemporal organization of the brain, and discusses how it can contribute f...

nature.com

🏁 Big news from #Cogitate!🏁 We’re proud to deliver the first part of our promised open multimodal dataset: iEEG data from 38 patients across 3 centers, collected under a unified protocol. 📄 Paper: doi.org/10.1038/s415... 📀 Data: www.arc-cogitate.com/data-release 💻 Code: github.com/Cogitate-con...

First post on an exciting new manuscript online today @natneuro.nature.com - in collab with @lucinauddin.bsky.social and Catie Chang. We take a fresh look at the physiological dynamics associated with the global signal 🧠 ... www.nature.com/articles/s41... Read here: rdcu.be/ek01F

Autonomic physiological coupling of the global fMRI signal

Nature Neuroscience - The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.

rdcu.be

It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠

A network correspondence toolbox for quantitative evaluation of novel neuroimaging results - Nature Communications

Here, the authors present the Network Correspondence Toolbox, which enables researchers to examine and report spatial correspondence between their neuroimaging results and widely used brain atlases.

nature.com

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization 🔗 doi.org/10.1101/2025... 🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇 #neuroskyence

The molecular and cellular underpinnings of human brain lateralization

Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...

doi.org

🧠🌱 New preprint from the IGOR Sustainability project! "There is no research on a dead planet" How can we balance neuroscience, open science, and climate responsibility? 📄 Read our position paper on OSF: osf.io/preprints/osf/rju75_v1

Now out in NPJ Digital Medicine our manuscript on real-world evidence for altered communication preferences in autism: nature.com/articles/s41... @sbe.bsky.social @leoschilbach.bsky.social

Real world evidence for altered communication patterns in individuals with autism spectrum disorder - npj Digital Medicine

npj Digital Medicine - Real world evidence for altered communication patterns in individuals with autism spectrum disorder

nature.com

Bluetorial-A dream and a bit of a nightmare Serving as Editor-in-Chief at Science was fascinating. I greatly enjoyed working with talented and committed editorial, news, graphics, and production staff. But the inside look into scientific publishing and AAAS was also deeply disillusioning.

a cartoon says hey everybody an old man 's talking while bart simpson looks on

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

media.tenor.com

🎉 New Year, New Preprint. Happy to share the first preprint from my #PhD! 🧠 🤔 TL;DR: Our findings are relevant to anyone using EEG / MEG functional connectivity analyses. They affect the choice of method when analysing your data. Check it out and tell me your thoughts: shorturl.at/TD3wc 1/6

Zero-phase-delay connectivity increases the reliability, concordance with structure, and prognostic ability of functional connectivity metrics

Zero-phase-delay synchrony between the activity of distant neural populations has been robustly observed. Nevertheless, contemporary electroencephalography and magnetencephalography functional connect...

biorxiv.org

A New Year's rant, for 2025 😊:

The effect of spherical projections on spin tests for brain maps | biorxiv.org/content/10.1... Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️

The limiting factor for MRI based prediction of behavioral traits may be neither the imaging nor the pipeline or learning algorith but rather the reliability of the target phenotypes Thought provoking work my Martin Gell et al: www.nature.com/articles/s41...

How measurement noise limits the accuracy of brain-behaviour predictions - Nature Communications

Our ability to identify associations between behaviour and brain imaging is important for uncovering markers of cognition and disease. Here, the authors illustrate the importance of the reliability of...

nature.com

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

Altmetric@altmetric.com · 2y ago

There are already many articles for which there is more attention on Bluesky than on other comparable micro-blogging sites, meaning the academic community and the general public have clearly adopted Bluesky as one of its core places to disseminate and discuss new research. A Place of Joy.

New paper out today in PNAS 🎉 demonstrating: 1) an association between social disadvantage & child brain function can be observed as early as birth 2) these alterations are brain-wide, but most pronounced in functional networks & subcortex later linked to childhood adversity doi.org/10.1073/pnas...