In a meta-analysis of 210 biomedical AI studies that statistically compared models under cross-validation, 97% used invalid statistical tests. Here's our new preprint doi.org/10.64898/202... led by @tianchu.bsky.social @hetuli.bsky.social @shaoshiz.bsky.social @nichols.bsky.social 1/N

Hello Bluesky! Below this post, you will find all my very interesting "new paper" threads. 🤓 Note that some of these are much older than the timestamp because I rescued them from Twitter to make them accessible for everyone.

Despite decades of research there are still no reliable biomarkers for any of the major psychiatric diagnoses. In this now published perspective in Molecular Psychiatry we consolidate evidence from genetics, exposome and neuroimaging research on the potential reasons underlying these failures.

The many-to-many problem of endophenotypes in psychiatry - a biological perspective - Molecular Psychiatry

Molecular Psychiatry - The many-to-many problem of endophenotypes in psychiatry - a biological perspective

nature.com

It's important to note that when discussing brain structure-function relationships across scales, that the definition of function changes with scale. Keep it straight! @sbe.bsky.social link.springer.com/article/10.1...

Anatomic & functional brain atlases: connecting functional flexibility with fixed infrastructure - Brain Structure and Function

Brain Structure and Function - Recent advancements in imaging across scales has propelled the development of anatomic brain atlases reflecting a wide range of cellular properties. It’s...

link.springer.com

🚨 New preprint alert! 🚨 Transdiagnostic latent factor models of psychopathology are widely assumed to improve brain-behaviour associations. So we decided to test this directly and found that they don't. A short 🧵 Link: www.biorxiv.org/content/10.6... 1/10

👉Up next, we are excited to welcome @sbe.bsky.social for our next CCP Speaker Series talk! Join us THIS FRIDAY, December 5th, at 1pm EST RSVP HERE for more details: docs.google.com/forms/d/e/1F...

✨ New preprint ✨ Introducing cuBNM, a toolbox we developed to run brain simulations *much* more efficiently on GPUs 🎉🚀 Preprint: www.biorxiv.org/content/10.1... Documentation: cubnm.readthedocs.io/en/stable/ GitHub: github.com/amnsbr/cubnm 1/n 🧵

✨ SHINY NEW PAPER ✨ Sleep-disordered breathing is associated with higher Aβ burden, lower rFDG, and worse cognition in Alzheimer's Disease. @sbe.bsky.social www.sciencedirect.com/science/article/pii/S0197458025001034

How is self-reported sleep-disordered breathing linked with biomarkers of Alzheimer’s disease?

Sleep-disordered breathing (SDB) is prevalent in Alzheimer’s disease (AD). Here, we assessed how self-reported SDB is linked with AD biomarkers, inclu…

sciencedirect.com

Excited to see this work published in @natcomms.nature.com! 🧠📊 In-vivo evidence of E/I alterations underlying functional changes in individuals with autism in the large ABIDE1 dataset AND replication in the independent ABIDE2 dataset.

New preprint from stellar IRTG PhD student Amelie Rauland + team on white matter bundle reconstruction! Shows that WM bundles can be reliably extracted from simple 32-direction dMRI & features predict cognition - huge potential for legacy and clinical data. Thread 👇 www.biorxiv.org/cgi/content/...

The end of a PhD journey 🎓 What a ride - full of lovely people, exciting science, coding tunnels, coffee-brainstorms & amazing conferences! Whole-hearted thank you to all who shared the journey & celebrated with me - especially @sofievalk.bsky.social, @sbe.bsky.social &@mps-cognition.bsky.social 💐🥳❤️

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...

Amelie Rauland (all star via IRTG student w/ @sbe.bsky.social ) will be presenting "Benchmarking Reconstruction Methods for Bundle Segmentation in Single-Shell dMRI" on Friday and Saturday, Poster #1283

#ABCD-J #Studienhighlights: Eine kürzlich erschienene Studie zeigt mittels #JTrack Social Unterschiede in Kommunikationsmustern zwischen neurotypischen Erwachsenen und Erwachsenen mit #Autismus-Spektrum-Störung auf. Neugierig geworden? Das ganze Highlight gibt es hier: www.abcd-j.de/de/showcases...

🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence? We asked this in our new paper just out in #ScienceAdvances ✨ “Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling” 📄 www.science.org/doi/full/10.... 🧵⤵️

Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling

Individualized simulations reveal a decrease in excitation-inhibition ratio in association areas throughout adolescence.

science.org

⭐ new paper Maturation of cortical excitation-inhibition (EI) in adolescence now in Science Advances 💥 A true tour de force of multimodal MRI, connectomics & GPU-powered 🤖!! biophysical modelling by hiball superheroes 🦸‍♂️🦸‍♀️🦸‍♂️ @amnsbr.bsky.social @sofievalk.bsky.social @sbe.bsky.social

Amin Saberi@amnsbr.bsky.social · last yr.

🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence? We asked this in our new paper just out in #ScienceAdvances ✨ “Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling” 📄 www.science.org/doi/full/10.... 🧵⤵️

Our #metaanalysis (n = 231) in JAMAPsych reveals consistent brain abnormalities across #sleep disorders involving affective and cognitive hubs in sgACC, amygdala/hippocampus Short-term sleep deprivation shows a distinct picture, affecting the thalamus jamanetwork.com/journals/jam...

It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠

A network correspondence toolbox for quantitative evaluation of novel neuroimaging results - Nature Communications

Here, the authors present the Network Correspondence Toolbox, which enables researchers to examine and report spatial correspondence between their neuroimaging results and widely used brain atlases.

nature.com

Always thought we should use connectivity blueprints to investigate differences between human, chimpanzee, and macaque brains? www.jneurosci.org/content/earl... For Katherine Bryant’s latest masterpiece.

Connectivity profile and function of uniquely human cortical areas

Determining the brain specializations unique to humans requires directly comparative anatomical information from other primates, especially our closest relatives. Human ( Homo sapiens ) (m/f), chimpan...

jneurosci.org

NOW, Join if you're interessted Topic: DGKN Hackroom 2025 — Tool Talks Time: Mar 14, 2025 10:30 - 12h fz-juelich-de.zoom.us/j/6792251876... Data Management: 10:30 – 11:00 Datalad: GPDR conform collaboration Jtrack: remote wearable assessment

Now out in NPJ Digital Medicine our manuscript on real-world evidence for altered communication preferences in autism: nature.com/articles/s41... @sbe.bsky.social @leoschilbach.bsky.social

Real world evidence for altered communication patterns in individuals with autism spectrum disorder - npj Digital Medicine

npj Digital Medicine - Real world evidence for altered communication patterns in individuals with autism spectrum disorder

nature.com

A new #Neurosalience episode is out! 🧠 From Big Data to Biomarkers with Peter Bandettini @fmri-today.bsky.social and Simon Eickhoff @sbe.bsky.social youtu.be/z91SiENsgF8

Neurosalience #S5E10 with Simon Eickhoff - From Big Data to Biomarkers

YouTube video by Organization for Human Brain Mapping

youtu.be

Dazu integrieren wir – das Institut für Neurowissenschaften und Medizin: Gehirn und Verhalten (INM-7) @fz-juelich.de, und unsere klinischen Partner an den Unikliniken Aachen, Bonn, Köln, und Düsseldorf – verschiedene technische Lösungen zu einer digitalen Plattform und vernetzen uns.

ABCD-J@abcd-j.bsky.social · last yr.

Hallo Bluesky! Zeit für unsere #Vorstellung. Hier postet das #ABCD-J Projekt. Wir sind eine vom Land NRW geförderte Initiative für die Verbesserung von klinischer Forschung mittels #Biomarkern und #mobileHealth.

Thanks to everyone's feedback, we have updated our calculator to optimize sample size N & scan time T for fMRI studies: leonoqr.github.io/ORSP_Calcula... The first new feature is that users can explore how different N & T leads to different accuracy, e.g., N=1000 & T=30min => 81% max accuracy. 🧵

The limiting factor for MRI based prediction of behavioral traits may be neither the imaging nor the pipeline or learning algorith but rather the reliability of the target phenotypes Thought provoking work my Martin Gell et al: www.nature.com/articles/s41...

How measurement noise limits the accuracy of brain-behaviour predictions - Nature Communications

Our ability to identify associations between behaviour and brain imaging is important for uncovering markers of cognition and disease. Here, the authors illustrate the importance of the reliability of...

nature.com

This is what happens if preprints are treated as „scientific literature“ Don’t get me wrong, I am all for preprinting. But unfortunately, it is often ignored that anybody can preprint anything

Mark Pallen@mjpallen.bsky.social · 2y ago

Letter sent in to the Editor of the Guardian on brain microbiome nonsense.

We created a #neuroinformagical (obvs) starter pack! Let us know who else to add! #openscience #datasharing #neuroskyence 🧪 go.bsky.app/LRqnaMP

woo hoo - fantastic new work from ‪@wanb.bsky.social‬ @sofievalk.bsky.social @sbe.bsky.social & many more on microstructural asymmetry now out in Nature Comms ⤵️

Bin Wan@wanb.bsky.social · 2y ago

Thrilled to share my latest work "Microstructural asymmetry in the human cortex" now out in NatComms. www.nature.com/articles/s41... This work used cytoarchitecture (BigBrain), T1w/T2w, qT1, and MT measures to bring the cortical asymmetry from macrostructure to microstructure.