I am excited to share that I will be opening my lab as a tenure-track Assistant Professor in the Department of Pharmacological Sciences at Stony Brook University Renaissance School of Medicine, beginning in March 2027. @stonybrooku.bsky.social @stonybrookmedicine.bsky.social www.prakash-lab.org

Astrocytes do so much more than any of us thought - they even communicate among specific brain regions across hemispheres! The journey to this paper spanned nearly a decade, but I'm most excited to see what everyone else does with the tools we've built. There's so much for all of us to explore!

Astrocytes connect specific brain regions through plastic networks - Nature

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

nature.com

Thrilled to share our new publication on the regulatory code of injury responsive enhancers in the CNS! www.nature.com/articles/s41... @ellorens.bsky.social @ki.se @natneuro.nature.com

I was featured on The Scientist as a part of their 'Postdoc Portraits' series where I spoke about my scientific career path and ongoing work on oligodendrocyte dysfunction in neurodegeneration. Check it out! www.the-scientist.com/postdoc-port...

Postdoc Portrait: Priya Prakash

This postdoc uncovers how glial dysfunction drives neurodegeneration in a rare movement disorder.

the-scientist.com

#SfN #SocietyForGlia STARTING NOW! Ending strong with the last www.liddelowlab.com presentations of the week. @pryprk.bsky.social talking about a world first mouse model for XDP... and OLIGODENDROCYTES! @melcooperphd.bsky.social presenting on astrocyte networks in the mouse forebrain.

📄🚨: Building off a stellar 2023 pub that engineered an hCSF1R variant, Sonia et al. now show how an mCSF1R variant not only confers inhibitor resistance and allows for efficient & non-toxic microglia replacement, but does so after vascular delivery into immunocompetent mice! 👏🧠 tinyurl.com/3wvmm8v3

Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells

Microglia replacement holds great promise for the study and treatment of neurological diseases. We previously achieved high-efficiency replacement by …

tinyurl.com

Looking forward to presenting our work on oligodendrocyte dysfunction in a rare neurodegenerative movement disorder X-linked Dystonia Parkinsonism. Come say hi if you're around on Tuesday, Nov 18 between 1-5 pm! @sfn.org #SfN2025 #SfN25

Shane Liddelow@liddelowsa.bsky.social · 9mo ago

@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below. Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social. (1/2)

@sfn.org #SfN25 #SanDiego starts this Saturday. The lab is going to be there in full force - see our presentations below. Represented this year by @borderbiologist.bsky.social, Nick Kathman, @mrodea.bsky.social, @melcooperphd.bsky.social, @pryprk.bsky.social, @kerrylimberg.bsky.social. (1/2)

I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene. Read our two companion papers: 🔹 www.biorxiv.org/content/10.1... 🔹 www.biorxiv.org/content/10.1... 🧵 Highlights below!

Astrocytes are connected by gap junctions in large, plastic networks that link brain regions not connected by neurons, a new preprint shows. By @callimcflurry.bsky.social #neuroskyence www.thetransmitter.org/astrocytes/a...

Astrocyte networks span large swaths of brain

The networks are plastic, connect brain regions that aren’t connected by neurons and may enable long-distance communication between astrocytes, a new preprint shows.

thetransmitter.org

A big thank you to The Transmitter and @callimcflurry.bsky.social for the spotlight on our preprint! You can check out her article below, or the preprint here: doi.org/10.1101/2025...

The Transmitter @thetransmitter.bsky.social · 11mo ago

Astrocytes are connected by gap junctions in large, plastic networks that link brain regions not connected by neurons, a new preprint shows. By @callimcflurry.bsky.social #neuroskyence www.thetransmitter.org/astrocytes/a...

Now on bioRxiv! Astrocytes in one brain region (cyan) communicate in expansive networks (magenta). Through tool development, tissue clearing, and many hours on our @zeiss-microscopy.bsky.social Z1, we now know these networks are repeatable across mice, plastic, and specific. doi.org/10.1101/2025...

Astrocytes connect specific brain regions through plastic gap junctional networks https://www.biorxiv.org/content/10.1101/2025.07.18.665573v1

Happy to share that our work "Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease" is out now @cp-immunity.bsky.social! ➡️ www.cell.com/immunity/ful...

Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease

Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and lose their phagocytic cap...

cell.com

Thrilled to announce that my lab is now open at Ohio State! We study astrocytes as gene therapy targets for brain repair after ischemic stroke and in vascular dementia, developing new viral tools along the way. If you're interesting in joining or collaborating, please reach out! gleichmanlab.com

Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.

Immunity@cp-immunity.bsky.social · last yr.

Online now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease

Amped to share this masterclass of a paper spearheaded by @waisenberg.bsky.social, out today in Immunity. Will et al. provide a deeply detailed look into microglia dysfunction in Krabbe disease & show that microglia replacement therapeutically improves disease outcomes! www.cell.com/immunity/ful...

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease

Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated ...

cell.com

New preprint evaluating the recent claim of epigenetically regulated immune memory in astrocytes. We believe this finding was likely artifactual, resulting from immune cell contamination & cell type mis-annotation across multiple transcriptomics experiments:

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · last yr.

Epigenetic memory astrocytes are likely an artifact of immune cell contamination https://www.biorxiv.org/content/10.1101/2025.04.04.647246v1

Fresh off the press! We found that degeneration in one retina causes astrocytes to respond retinotopically across *both* hemispheres of the brain. Perhaps astrocytes across the CNS are able to coordinate their responses more than we anticipated... www.pnas.org/doi/10.1073/...

At @standupforscience.bsky.social and the signs are statistically significantly excellent

Our paper on the superficial glia limitans is now published - huge thank you to all co-authors that helped getting this work across the finish line! www.cell.com/cell-reports...

Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates

Hasel et al. show that molecularly and morphologically specialized astrocytes make up the brain and spinal cord surface, thereby creating the glia limitans superficialis. These astrocytes selectively ...

cell.com

If you can, do something, speak up and act up. www.science.org/doi/10.1126/...

Scientists as political advocates

Science, both teaching and doing, is under attack. The recent US presidential election of a person and platform with anti-science bias exemplifies this. The study of climate processes and patterns and...

science.org

#GliaPapers #GliaSpecial2025 REVIEW @mrodea.bsky.social, @philiphasel.bsky.social Are we there yet? Exploring astrocyte heterogeneity one cell at a time onlinelibrary.wiley.com/doi/10.1002/...

#GliaPapers #GliaSpecialIssue SPECIAL COVER SPECIAL ISSUE: Glial omics: unraveling mechanisms in health and disease onlinelibrary.wiley.com/toc/10981136... Editorial Unboxing “Omics” in Glial Biology to Understand Neurological Disease here - onlinelibrary.wiley.com/doi/10.1002/...

Special Issue: Glial omics: Unraveling mechanisms in health and disease: Glia: Vol 73, No 3

Glia is the top neurobiology journal for research into glial cells (also called gliocytes or neuroglia). Articles cover all aspects of glial cell biology in health and disease.

onlinelibrary.wiley.com

Scientific advancements aside, this is economically irresponsible Every $1 spent by NIH generates $2.46 For example, in 2023, $47B in NIH spending generated ~$93B Halting NIH spending will LOSE the US a lot of money (and talent)

Adam Rogers@jetjocko.bsky.social · 2y ago

They…turned off…National Institutes of Health grants? That’s nearly $50 billion of scientific research.

We are happy to share our enhancer scramble story, a strategy to create hundreds of stochastic deletions, inversions, and duplications within mammalian gene regulatory regions and associate these new architectures with gene expression levels 🧵 www.biorxiv.org/content/10.1...

First 🦋 post! Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental #glial biology to #stem cells and #tumor biology. rdcu.be/d5ADz A 🧵

Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma

Nature Cell Biology - Sojka et al. analyse the transcriptomic and epigenomic landscape of human astrocyte maturation and identify an epigenetically regulated intermediate state associated with...

rdcu.be

3 reviews on planning, execution, & validation of transcriptomic experiments in neuroscience published in @natureportfolio.bsky.social #NatureNeuroscience. A MUST READ if you're doing transcriptomics. 3 reviews, an amazing editorial, a beautiful cover – this is the issue of the year! (mini thread)

Big day for single cell and neuroscience. Trio of single cell perspective pieces discussing applications, opportunities, challenges, and validation of single cell and spatial genomics in neuroscience are out now in Nature Neuroscience. Links in thread below.👇 1/n