Flying over the Olympics today and it's so smokey out here :(
Lindsay K Pino
@lindsaykpino.com
#massspectrometry, #proteomics, and #bioinformatics | hiking and coffee | co-founder & CTO @talusbio | opinions my own
On August 1, 1931, Harriet Creighton and Barbara McClintock published the first experimental proof that genes are physically located on chromosomes—a discovery that transformed genetics. 1/3🧵
Many people who go through an ordeal emerge with one of two attitudes: “Nobody else should suffer like I did,” or “I got through it, so everybody else should suffer just like I did.” In this week's column, how to deal with a boss from the latter group. slate.com/advice/2026/...
I Just Returned to Work From Maternity Leave. My Boss Is Sabotaging Me.
She's being unreasonable.
slate.com
I've had the behind-the-scenes view of @willfondrie.com building structure-free, residue-level compound:protein binding predictions from just sequence + 2D chemistry alone the last few months at @talusbio.bsky.social and can we just talk about how ridiculously talented he is?! 😤🧬⛰️ 💻🧪🍝
Will Fondrie@willfondrie.com · 6d agoNew @talusbio.bsky.social #AI preprint just dropped 🚀 Meet Ptarmigan-1. It predicts which small molecules bind a protein, and which residues they hit, from sequence and 2D chemistry alone. No structures, no docking, no poses. www.biorxiv.org/content/10.6... Time for a 🧵 (1/13)
(11/13) I guess what I'm trying to say is: Welcome to the structure-free future of drug discovery.
Sr Scientist I Analytical Chemistry- Mass Spec AbbVie - Irvine, US Read the full job description and apply⤵️ jobrxiv.org/job/sr-scien... #ScienceJobs
Heading to #HUPO2026? Registration is now open for Evosep’s HUPO events, including our Breakfast Seminar and User Appreciation Event on September 28. Join us to connect with the proteomics community and hear the latest science. Register: evosep.com/hupo2026 #Proteomics #LCMS
OK folks – decision made. I’m spending too much time following all things proteomics and need to move on to pastures new – Immunodiagnostics. Pastel’s website will be available until it’s renewal in 5months time. 1/3
One of my new things is pinball and today we went to check out a new bar and a dude here is absolutely crushing Attack on Mars
If context management isn't on your radar yet, it should be. Ex. I made a repo template just for my own workflow context management. But the idea here was to use context management to help make vibe-coded software not break rules set in the GROUNDING.md. github.com/neely/agent-... 2/7
Self-promotion or PSA, a little of both? Our (@magnuspalmblad.bsky.social and Jared Ragland) Letter is out in JPR, which tackled the age old question "how can we make AIs follow community-supported domain knowledge?" Answer: use a GROUNDING.md file in your context. 1/7 pubs.acs.org/doi/10.1021/...
Agentic AI-Assisted Coding Offers a Unique Opportunity to Instill Epistemic Grounding during Software Development
The capabilities of AI-assisted coding are progressing at a breakneck speed. Chat-based vibe coding has evolved into fully fledged AI-assisted, agentic software development using agent scaffolds, wher...
pubs.acs.org
Regardless of AI- vs human-made, there's some solid points here. one that resonates with me rn: "Speed at the individual level without alignment at the team level produces a graveyard of half-finished, un-launched work. Sure, everyone’s fast; but nothing’s live. www.nfx.com/post/ai-firs...
How The Fastest AI-First Companies Really Work
Learn how the fastest AI-first companies use mission pods, AI teammates, tight feedback loops, and lean teams to ship faster and learn faster.
nfx.com
Do you want to work at the frontier of structural and chemical #proteomics? Interested in induced proximity and building a feedback loop for machine learning models to explore biology? I'm hiring! Apply below ⬇️ jobs.ashbyhq.com/proxima/6e39...
Proteomics Scientist
Proteomics Scientist
jobs.ashbyhq.com
Ubuntu Proteomics Summer School. In case you're in doubt whether you should go register, watch this video 😎 youtube.com/shorts/iASW1...
Posting my talk today for tutorial IP2 at @iscb.bsky.social's #ISMB2026: LLMs & Agentic AI for Biomedical Informatics (organized by R Tang) lectures.gersteinlab.org/summary/LLMs... Has lots of slides on case studies for LLMs in brain genomics & comparisons with more classic approaches
Ok this is absolutely great. Larry Hunter talking about 1990's, coming out of AI winter and making a popular gopher page to reach out to other computational biology people and eventually starting ISMB #ismb2026
Kicking off #ismb2026 with some background context on the org and the meeting -- "Don't be surprised if something like [sic: the AI winter of late 1980s, early 1990s] happens again." - Larry Hunter, founding father of ISMB
Really cool collaborative opportunity here for scientific exchange for #teammassspec #proteomics More info here: us-hupo.org/scientist-ex...
US HUPO - Scientist Exchange Program Award
us-hupo.org
US HUPO@us-hupo.org · last mo.📢 Applications open for the US HUPO Scientist Exchange Program Award! Get up to $5,000 for research travel, mentorship, and collaboration at a US lab. Apply by Sept 11, 2026. #USHUPO #Proteomics
My department, Neurobiology and Biophysics at the University of Washington (nbio.uw.edu), is hiring a new tenure-track Assistant Professor, application deadline 09/30/26. It's a broad search — molecular to organismal, all of neuroscience/physiology/biophysics welcome. apply.interfolio.com/187735
Pls share: U of Washington has an opening for a tenure-track faculty position at the rank of Assistant Professor. This position is expected to specialize in molecular virology or bacteriology. Here is a link: microbiology.washington.edu/index.php/ne...
Micro is Hiring! | UW Microbiology
microbiology.washington.edu
Amazing to see @arianashannon.bsky.social win this award!!
ASMS@asms.org · 2mo agoCongratulations to the recipients of the 2026 ASMS Postdoctoral Career Development Awards! These awards support the professional growth of postdoctoral fellows in the field of mass spectrometry, helping fund opportunities. #TeamMassSpec #ASMS #MassSpecCommunity #FeMS #ASMS2026
I wanted to share some news: I'll be leaving the NCI at the end of August. I'm excited to share more about the lab's next step soon, but for this post wanted to focus on expressing gratitude for my colleagues, trainees, and friends at the NCI Center for Cancer Research.
Favorite talk of #ASMS2026 so far has got to be this HIGH SCHOOLER presenting in the drug discovery session!!
Amazing talk and beautiful slides, @willfondrie.com -- hope your ML short course participants were paying attention!! 🐔
Lindsay K Pino@lindsaykpino.com · 2mo agoMonday, @willfondrie.com and I are kicking things off with a couple of talks, and then I'll be moderating a workshop about entrepreneurship with Paula Burton from @massdynamicsco.bsky.social
GOOD MORNING! Starting the day off at the @sciex.bsky.social breakfast seminar. All you runners put me to shame on my walk over here, but I'll be making it out for a jog one of these days. Probably. Maybe.
Lindsay K Pino@lindsaykpino.com · 2mo agoMonday, @willfondrie.com and I are kicking things off with a couple of talks, and then I'll be moderating a workshop about entrepreneurship with Paula Burton from @massdynamicsco.bsky.social
A historical review of computational mass spectrometry by @maccoss.bsky.social at #ASMS2026, beginning with the mother of bioinformatics, Margaret Dayhoff. 🖥️🧬🧪👩🔬
New work from @csneeze.bsky.social explored how common additives for thermal stability analyses affected protein-drug interaction hit calling. We were surprised to see that buffer and method selection for lysates could recapitulate findings from in cell thermal stability assays!
Catherine Sniezek@csneeze.bsky.social · 2mo agoExcited to share our latest preprint from us at the Schweppe Lab detailing detergent impacts to thermal stability with consequences for thermal profiling: DDM behaves quite differently from NP-40 when used as a component of a melting buffer! @dschweppe.bsky.social www.biorxiv.org/content/10.6...