Heather Clendenin🐾🧬

@littlemuseums.bsky.social

Conservation genomics, landgen, and molecular evolution (mostly 🐻, some 🐺, and an affinity for 🐈).

I was a little spoiled the last few years of my PhD and had ~*~my own office~*~ and it worked out pretty well. But then I pop into the group office to help troubleshoot some code and see the whiteboard content (silly stuff primarily captured here), and now I have to rethink some things.

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Great, now I can’t use the one pdf map I uploaded to Avenza nor can I add points, tracks, etc. unless I “upgrade” to a paid account. I used this app for free during my entire PhD field work. Anyone using alternative free mapping apps these days?

Craig Smail wrote up a really nice Preview of @nikhilmilind.dev's paper where we try to explain why large effect variants tend to affect traits in the same direction on average, which we think about in terms of the non-linearity of gene dosage response curves. www.cell.com/cell-genomic...

Gene dosage differences and non-linear impacts on complex traits

Large differences in gene dosage are usually associated with opposite phenotypic effects but show a bias toward one direction in aggregate genome wide. Milind et al. suggest that this is explained by ...

cell.com

🔥 Does switching to a pangenome reference actually improve your association study? We tested it, and the answer is yes, measurably. Our preprint is online now: "Pangenome-based human genome analysis improves trait association and genomic prediction": doi.org/10.64898/202...

Pangenome-based human genome analysis improves trait association and genomic prediction

The Human Pangenome Reference Consortium has generated 462 open-access reference genomes and a variation graph that represents differences among them, providing a substrate for pangenome-based analysi...

doi.org

Our paper is out! 📣 we find that molecular measures of genetic variation do not predict heritable genetic variation across species - important implications for the application of genomic data for conservation! www.pnas.org/doi/10.1073/...

Nucleotide diversity is a poor predictor of short-term adaptive potential | PNAS

The capacity to adapt is essential for a population to avoid extinction in a changing world and is recognized as a global conservation priority. Ad...

pnas.org

Great apes may have been laughing with a similar rhythm to modern humans for at least 15 million years, suggests a study in Communications Biology. The findings also suggest that laughter has become faster, more variable, and increasingly influenced by the situation it occurs in. #evosky 🌎🧪

Rhythm and timing in laughter reveal that human vocal plasticity falls on a hominid continuum - Communications Biology

Comparative analysis of laughter rhythm across all extant great apes reveals that isochrony is ancestral to hominids, with tempo, variability, and context-sensitivity increasing progressively toward humans, tracing a continuum of vocal plasticity.

go.nature.com

I haven’t used Tiktok in the last few years, but now that I’ve passed my defense & have a little downtime, I’m here getting teary over all of the Great American Sleepover content. Either it’s great or I still need a bit of a system reset 🙃 Also, I’m maybe burying the lede, but it’s Dr. Catnerd now

10 colour palettes I reach for in research charts — curated, and most are colourblind-safe. Categorical + sequential: Okabe-Ito, Paul Tol, Tableau 10, viridis, cividis, magma. Skip default tab10 and rainbow/jet. Which do you swear by? Anything I'm missing? #DataViz #ColorPalette #SciComm

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