Daratumumab in lupus 🦋 – results of our single-arm trial: 10 patients 8x daratumumab (1/week) at week 12: ☑️ reduced dsDNA antibodies ☑️ Median SLEDAI 12 > 4 ☑️ SRI-4 at 12 weeks 100% ☑️ immunology improved* out now at @nature.com Communications: www.nature.com/articles/s41... #medsky #nephsky 🧪 1/

www.youtube.com/watch?v=F2Pw... I love the BBC Radio 1 Essential Mixes.

Radio 1’s Essential Mix with Barry Can't Swim at The Warehouse Project

YouTube video by BBC Radio 1

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Our case report of a patient developing drug-induced systemic sclerosis after bleomycin exposure – still showing antibodies after 5 years. Nicely done Philipp 🎉 #rheumsky authors.elsevier.com/sd/article/S...

Join us at Charité University and the IMPRS-IDI Graduate Program in Berlin to unravel NK cell clonality and memory! We are looking for motivated PhD candidates who are passionate about immunology. @romagnanilab.bsky.social @timorckert.bsky.social Apply now 👉 www.imprs-idi.org/home/

Max Planck Institute for Infection Biology@mpiib-berlin.mpg.de · 9mo ago

Looking for a #PhD project in #+immunology? The @romagnanilab.bsky.social offers two fully funded projects “Dissecting the Molecular Pathways of NK Cell Clonality” & “Dissecting the Molecular Pathways of NK Cell Memory“. Apply by Dec 10 👉 www.mpiib-berlin.mpg.de/1947490/rese...

Our paper on the second Berlin patient came out in Nature today and I’m really happy we can share this story on World AIDS Day. I want to thank everyone on the team and all co-authors for their work over the years. www.nature.com/articles/s41...

We are live The @theisn.org launches a new journal www.sciencedirect.com/journal/kidn...

www.youtube.com/watch?v=cxxI...

Rival Consoles - Untravel (Official Music Video)

YouTube video by Erased Tapes

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So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth! #protistsonsky 🧵

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 8mo ago

A geothermal amoeba sets a new upper temperature limit for eukaryotes https://www.biorxiv.org/content/10.1101/2025.11.24.690213v1

INCREDIBLE CURVES

Just 4 days until the start of I2K and its 33 totally free image analysis tutorials and events! Please share with your "home networks", especially early career researchers - the videos will be amazing and high-impact no matter how many people attend live, BUT (1/x)

Adapting the 10x workflow to detect EBV reads, Younis et al show that EBV-transcribing B cells are increased in SLE patients, especially among CD27+CD21low B cells. They have autoreactive BCRs and are more poised for antigen-presentation. 2025 Sci Transl Med 🧪 ⑂ www.science.org/doi/10.1126/...

www.youtube.com/watch?v=BOtC... 🔥

Fred again.., Ezra Collective, CA7RIEL & Paco Amoroso - Beto’s Horns, Ezra Remix (London, 25th June)

YouTube video by Fred again . .

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What mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)? In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13. www.biorxiv.org/content/10.1... 1/n #Nephsky 🧪

science is a TEAM SPORT there is no ISOLEUCINE in THREONINE GLUTAMATE ALANINE METHIONINE

Thylacine – very cool multi-instrumental electronic session #musicsky www.youtube.com/watch?v=NM51...

THYLACINE - Live session 2024 @ Intuitive Studio

YouTube video by Thylacine

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🧠🌟🐭 Excited to share some of my postdoc work on the evolution of dexterity! We compared deer mice evolved in forest vs prairie habitats. We found that forest mice have: (1) more corticospinal neurons (CSNs) (2) better hand dexterity (3) more dexterous climbing, which is linked to CSN number🧵

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 10mo ago

Evolutionary expansion of the corticospinal system is linked to dexterity in Peromyscus mice https://www.biorxiv.org/content/10.1101/2025.10.16.682851v1

Ubiquitinylation is more complex than just a signal for proteasomal degradation: Linear ubiquitinylation of Methionine-1 is important for NFkB signalling. LOF of the Deubiquitinylase OTULIN leads to an autoinflammatory disease with a TNF positive feedback loop. 🧪 ⑂ 1/2

Tregs in the skin reduce the activation of sensory neurons by producing enkephalin. This inhibits secondary inflammatory changes mediated by the neurons. (in 🐭) 🧪 ⑂ Mendoza et al 2025 in Science Immunology www.science.org/doi/full/10....

HLA matching or CRISPR editing HLA-I/II enables engraftment & function of allo human Treg therapy in a humanized mouse transplantation model @natcomms.nature.com @dlwagner.bsky.social @bcmhouston.bsky.social www.nature.com/articles/s41...

CRISPR screening factors influencing Th1 vs Th2 differentiation, RAMP3 which forms part of a CGRP receptor is a positive regulator of Th1 differention. CGRP acts by increasing intracellular cAMP and ultimately ATF3 activity it induces STAT1 and thereby Th1 differentiation. in 🐭 🧪 ⑂ 1/2

Friday Papers Club! 🍿In light of Pubmed going down, the collapse of social media, and my recent success at getting recommendations for interesting papers from those still around, I am starting a new tradition! - Recommend a good scientific manuscript! 👇

You like engineering T cells, but you are missing the right flavor? Check out 'one-pot' PASTA recipe 🔥🍝: www.biorxiv.org/content/10.1101/2025.09.10.675267v1 We combined a unique mix of CRISPR knock-in with serine integrases for easy-to-adopt 𝐏rogrammable 𝐀nd 𝐒ite-specific 𝐓ransgene 𝐀ddition 🧪

Versatile and efficient non-viral integration of large transgenes in human T cells via CRISPR knock-in and engineered integrases

Current gene transfer methods often lack the precision, versatility, or efficiency when integrating large transgenes, limiting the ability to engineer therapeutic T-cells with more complex payloads. H...

biorxiv.org

A conference of three primates, discussing videography and their varying perspectives on nature documentaries. Jane Goodall and husband Hugo van Lawick, 1974. Third primate's name unknown.

Jane Goodall, the trailblazing naturalist whose intimate observations of chimpanzees in the African wild produced powerful insights that transformed basic conceptions of humankind, has died. She was 91. Read more about her legacy www.latimes.com/obituaries/s...

For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.

Rarely is a taped live performance so much better than the original. Love this Maribou State recording start to finish 🔥 Great for doing annoying point and click data analysis today. www.youtube.com/watch?v=oQjg2QEvEX0

Maribou State Live From Alexandra Palace, London

YouTube video by DJ Mag

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For our #flowcytometry peeps, would you like to have a single fix/perm protocol that is optimised for everything? One that preserves fluorophores while allowing simultaneous TF and cytokine staining? How about 100-fold cheaper? You got it: currentprotocols.onlinelibrary.wiley.com/doi/10.1002/...

So proud of these guys. Amazing final game, the turkish team played impressive basketball, but in the end we prevailed 🔥🏀

Plasmacytoid dendritic cells can transition to become cDC2s under to influence of TNF, while type-I interferon reduces TNFR expression and thereby inhibits transition. These transitioned cDC2 seem fully functional. 🧪 ⑂ Hornero et al 2025 in Nat Immunol www.nature.com/articles/s41...

Horisberger et al separate Lupus nephritis patients in 3 groups by blood: healthy-like, interferon-dominant and CD8 T cell-dominant. The CD8 T cell-dominant group had the highest biopsy activity score and highest response rate after 1 year; the healthy-like the most chronic damage. 🧪 ⑂ #NephSky 1/