Our article is out in Nature Communications! We identify ATP synthase as a new link between OXPHOS and the TCA cycle, and these interactions are remodelled upon mitochondrial dysfunction. Co-authored with Jelena Misic, @tkadava.bsky.social, @nils-goranlarsson.bsky.social, @hecklab.bsky.social

These HTA proteases from archaea work great for mass spec-based antibody sequencing. Paper out now in final form at Cell Systems. Congrats to @tshamorkina.bsky.social @tkadava.bsky.social @lperezpaneda.bsky.social and @hecklab.bsky.social www.sciencedirect.com/science/arti...

A Universal Spectrum Annotator for Complex Peptidoforms in Mass Spectrometry-Based Proteomics pubs.acs.org/doi/10.... --- #proteomics #prot-paper

Deciphering protein long-chain S-acylation using mass spectrometry proteomics strategies pubs.rsc.org/en/cont... --- #proteomics #prot-paper

🕷️Spiders in your blood? Don’t worry, these are protein molecules of C4BP protein, part of your immune system. Just like real spiders, they grab prey with their “legs.” Watch them in action! Intrigued, check the paper of @tkadava.bsky.social doi.org/10.1016/j.mc... @bijvoet-centre.bsky.social

Are you looking forward to attending #EuPA2025 in beautiful Saint-Malo? Get ready for an enriching experience in extraordinary #proteomics! 🗓️ Mark your calendar for the SCIEX lunch symposium, taking place on Wednesday, June 18! 🔗 Full show agenda 👉 bit.ly/3HcA6Hw #SkepticsWelcome #ZenoTOF8600

Always interested to go beyond trypsin and CID @tshamorkina.bsky.social, @tkadava.bsky.social and @lperezpaneda.bsky.social, @cinderbio.bsky.social & @sciex.bsky.social produced https:// www.biorxiv.org/content/10.1101/2025.05.26.656138v1 & @asms.org. A truly improved de novo sequencing approach

Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry

The ability to sequence proteins without reliance on a genomic template defines a critical frontier in modern proteomics. This approach, known as de novo protein sequencing, is essential for applicati...

biorxiv.org

Excited to share our new preprint on archaeal proteases boosting reads in de novo antibody sequencing! Team effort with @tkadava.bsky.social @tshamorkina.bsky.social and @hecklab.bsky.social

PastelBio@pastelbio.bsky.social · last yr.

Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry www.biorxiv.org/cont... --- #proteomics #prot-preprint

Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry www.biorxiv.org/cont... --- #proteomics #prot-preprint

Check out our new preprint on combining archeal proteases with hybrid fragmentation to streamline de novo antibody sequencing! Joined effort with @lperezpaneda.bsky.social, @tshamorkina.bsky.social, and @hecklab.bsky.social

PastelBio@pastelbio.bsky.social · last yr.

Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry www.biorxiv.org/cont... --- #proteomics #prot-preprint

Excited to announce our revamped PhD-level BioMS course this September: Advanced Proteomics for Drug Discovery and Biotherapeutics Great line-up of instructors and topics, registration is open: www.hecklab.com/advanced-pro...