Our article is out in Nature Communications! We identify ATP synthase as a new link between OXPHOS and the TCA cycle, and these interactions are remodelled upon mitochondrial dysfunction. Co-authored with Jelena Misic, @tkadava.bsky.social, @nils-goranlarsson.bsky.social, @hecklab.bsky.social

A nice Polish - Dutch collaboration with the @iimcb.bsky.social. Congratulations to Mayra Borrero, Vanessa Linke and @tkadava.bsky.social. A dynamic gateway: Uncovering the expanded human TOM complex interactome and its regulatory complexity | Science Advances www.science.org/doi/10.1126/...

A dynamic gateway: Uncovering the expanded human TOM complex interactome and its regulatory complexity

Human TOM complex was revealed as a dynamic hub, with FKBP8 as a human-specific interactor shaping biogenesis.

science.org

These HTA proteases from archaea work great for mass spec-based antibody sequencing. Paper out now in final form at Cell Systems. Congrats to @tshamorkina.bsky.social @tkadava.bsky.social @lperezpaneda.bsky.social and @hecklab.bsky.social www.sciencedirect.com/science/arti...

🔬 For more, delve into this paper published in Molecular & Cellular Proteomics ( @asbmbjournals.bsky.social): www.mcponline.org/article/S153.... Congratulations to @tkadava.bsky.social, @hecklab.bsky.social and colleagues on this fascinating work!

Structural Insights Into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-Binding Protein Complexes With C4b and SAP

In BriefHere, we used an integrative approach to study key interactions of a spider-like complement inhibitor from human serum, C4b-binding protein (C4BP). We characterized interactions with complemen...

mcponline.org

American Society for Biochemistry and Molecular Biology@asbmb.bsky.social · 9mo ago

#Halloween Trivia 🕸️ Did you know human blood contains spider-shaped proteins that help regulate the innate immune response? 🕷️Discover how C4BP uses its eight “legs” to catch proteins and control inflammation: www.asbmb.org/asbmb-.... #Immunology #MolCellProt #MassSpec

#Halloween Trivia 🕸️ Did you know human blood contains spider-shaped proteins that help regulate the innate immune response? 🕷️Discover how C4BP uses its eight “legs” to catch proteins and control inflammation: www.asbmb.org/asbmb-.... #Immunology #MolCellProt #MassSpec

Having a great time at msandm2025.org with a great bunch of people interesting in visualizing biomolecules, together with my co-chairs @joostsnijder.bsky.social @vixklen.bsky.social & Kyle Fort. Learning so much from all posters & lectures. We thanks all participants for joining us in Utrecht.

Excited to see the C4BP in action. 🕷️ Check out the short movie by Sensu about our work from @hecklab.bsky.social lab.

Albert Heck@hecklab.bsky.social · 11mo ago

🕷️Spiders in your blood? Don’t worry, these are protein molecules of C4BP protein, part of your immune system. Just like real spiders, they grab prey with their “legs.” Watch them in action! Intrigued, check the paper of @tkadava.bsky.social doi.org/10.1016/j.mc... @bijvoet-centre.bsky.social

Last week to apply!

Vanessa Linke@massspecvanili.bsky.social · last yr.

🤩 JOB ALERT 🤩 Come work with me and two cutting-edge LC-MS/MS systems at our brand new Mass Spectrometry Facility @iimcb.bsky.social in Warsaw! Apply here tinyurl.com/y47mzafa or send any questions my way. #TeamMassSpec please share widely!

🕷️ Spiders from our blood 🕷️ Check out our new paper from @hecklab.bsky.social describing how the spider-like immune regulator C4BP interacts with its native binding partners. 🔗 www.mcponline.org/article/S153... #MassSpec #StructuralBiology

Structural Insights into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-binding Protein Complexes with C4b and SAP

C4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα and C4BPβ chains that non-covalent...

mcponline.org

Free structural MS hands-on workshop @ BIOCEV (CZ) 📅 Sept 15–19, 2025 For PhDs, postdocs & undergrads (CZ/SK) HDX-MS, native MS, cross-linking, high-res MS, data processing Apply by July 31 → bit.ly/3HNyzIg @spidocs.bsky.social @mbuavcr.bsky.social @ciisbinstructcz.bsky.social

Are you looking forward to attending #EuPA2025 in beautiful Saint-Malo? Get ready for an enriching experience in extraordinary #proteomics! 🗓️ Mark your calendar for the SCIEX lunch symposium, taking place on Wednesday, June 18! 🔗 Full show agenda 👉 bit.ly/3HcA6Hw #SkepticsWelcome #ZenoTOF8600

It has been nice to contribute to this nice piece of work together with @tkadava.bsky.social and @mattevilab.bsky.social

Spiders from our blood 🕷️ Excited to present our work with @hecklab.bsky.social at #ASMS2025 WP 611.

Excited to share our new preprint on archaeal proteases boosting reads in de novo antibody sequencing! Team effort with @tkadava.bsky.social @tshamorkina.bsky.social and @hecklab.bsky.social

PastelBio@pastelbio.bsky.social · last yr.

Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry www.biorxiv.org/cont... --- #proteomics #prot-preprint

Check out our new preprint on combining archeal proteases with hybrid fragmentation to streamline de novo antibody sequencing! Joined effort with @lperezpaneda.bsky.social, @tshamorkina.bsky.social, and @hecklab.bsky.social

PastelBio@pastelbio.bsky.social · last yr.

Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry www.biorxiv.org/cont... --- #proteomics #prot-preprint

Deep Coverage and Extended Sequence Reads Obtained with a Single Archaeal Protease Expedite de novo Protein Sequencing by Mass Spectrometry www.biorxiv.org/cont... --- #proteomics #prot-preprint