How do tissues safely remove cells? Join me, @marija-matejcic.bsky.social in this perspective on the past, present and future of epithelial cell extrusion 🧵 0/16

Thrilled to share our new work on the coupling between cell proliferation and intercellular stress organization! Cool collaboration between @bladoux.bsky.social / @rmmege.bsky.social lab and Doostmohammadi lab, combining experiments + simulations. Main points below : www.biorxiv.org/content/10.6...

A principal-stress rule for cell division in epithelia

Dense active materials, from cellular tissues to jammed and glassy systems, must continuously relieve internal mechanical stress to remain structurally stable as they are driven far from equilibrium. ...

biorxiv.org

Thrilled to share our new paper on cell extrusion. A beautiful study with a tremendous amount of data, led by the fantastic @fanny-wodrascka.bsky.social ! www.biorxiv.org/content/10.6...

Clearly, the use of LLMs to summarise and analyse scientific (or otherwise) documents is well justified. Their understanding is, at least, at a human level. The following example (image attached) strongly supports their intellectual capabilities. www.nature.com/articles/d41...

Some people should never have access to students. “AI requires no ramp-ups, no meetings, and absolutely no emotional support…The issue is not whether my students are valuable. In long run, they are invaluable. The issue is that their value emerges slowly, whereas AI delivers immediate returns.”

Why I may ‘hire’ AI instead of a graduate student

“It can competently perform a lot of the work I need immediately,” this professor writes

science.org

We had covered the history of traction force microscopy (TFM) earlier: bsky.app/profile/epim... But what about applying TFM into more physiologically relevant systems, such as those in 3D? I am @barrasa-fano.bsky.social and I'll be your guide through this thread on #3DTractionForceMicroscopy.

Barrasa-Fano, J., Shapeti, A., Apolinar-Fernández, A. et al. Guidance for 3D traction force microscopy today and in the next decade. Nat Methods (2025). #EpithelialMechanics buff.ly/eRFLGkt

Interested in the biophysics of organoids? We just published a review in Dev Cell—take a look! dlvr.it/TPyTb8 #Organoids #Biophysics

Biophysics of organoids

In this review, Weichselberger, Moore et al. discuss how physics-based approaches illuminate organoid development and homeostasis by integrating mechanical, chemical, and informational processes. They...

dlvr.it

Our paper on tissue stress measurements is now out in Eur. Phys. J. E. rdcu.be/eX59E. Great work from @luanger.bsky.social and @andreasschoenit.bsky.social and collaboration with P. Marcq @pmmh-lab.bsky.social Code: github.com/pmarcq/BISM/ and Examples on github.com/ASmushyCell/...

Reviewing process has always been painfull, but it will just become useless and impossible to publish if we start accepting this (we are not helping science...and better refusing to review if you have no time rather than using these tools without filter)

Tissue stress measurements — our latest preprint is out: arxiv.org/abs/2512.00550 (publication coming soon!) Fantastic work by the three musketeers — @luanger.bsky.social, @andreasschoenit.bsky.social and @fanny-wodrascka.bsky.social — in collaboration with P. Marcq!

Tissue stress measurements with Bayesian Inversion Stress Microscopy

Cells within biological tissue are constantly subjected to dynamic mechanical forces. Measuring the internal stress of tissues has proven crucial for our understanding of the role of mechanical forces...

arxiv.org

Finally! 🤩 Our position piece: Against the Uncritical Adoption of 'AI' Technologies in Academia: doi.org/10.5281/zeno... We unpick the tech industry’s marketing, hype, & harm; and we argue for safeguarding higher education, critical thinking, expertise, academic freedom, & scientific integrity. 1/n

📢 PhD Thesis defense 📅 November 26th 📍Institut Jacques Monod Fanny Wodrascka ( @fanny-wodrascka.bsky.social @bladoux.bsky.social @rmmege.bsky.social ) will defend her PhD thesis "Mechanical control of epithelial cell extrusion via RhoA-dependent contractility " ➡️ buff.ly/f5VaVah

My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site #microscopy #ImageJ #FluorescenceFriday #microscopyMonday imagej.net/plugins/imag...

Truly honoured and grateful to have received alongside other young researchers the prize "Grandes avancées françaises en biologie" from the @academiesciences.bsky.social for our paper on mechanical cell competition together with @luanger.bsky.social and S. Monfared www.nature.com/articles/s41...

Institut Jacques Monod@ijmonod.bsky.social · 9mo ago

📣 Andreas Schoenit, ( @andreasschoenit.bsky.social ) doctorant en biophysique dans le laboratoire "Adhésion cellulaire et mécanique" est lauréat des Grandes avancées françaises en biologie de la Fondation Mergier Bourdeix ! Plus d'informations 🔗 www.ijm.fr/prix-des-gra...

1/ 🐣⚒️ To study mechanics, we need to apply prescribed forces - how can we do that in living tissues? I am @eigenp.bsky.social and in this thread I'll highlight our new approach for applying tension on epithelial tissues in vivo!

Happy to share the last version of our story @currentbiology.bsky.social on the role of interfacial tension in mechanical cell competition led by @leovalon.bsky.social and Alexis Matamoro Vidal www.sciencedirect.com/science/arti...

Mechanobiology across timescales A Review by Bo Cheng, Moxiao Li, Min Lin, Hui Guo & Feng Xu ⚛️🧪 www.nature.com/articles/s42...

Mechanobiology across timescales - Nature Reviews Physics

This Review explores how cells sense and respond to mechanical signals across timescales. By integrating mechanosensing at membranes, mechanotransduction in the cytoplasm, and nuclear reprogramming, it reveals a role of temporal dynamics in tissue development and disease.

nature.com

John M. Martinis, Michel H. Devoret & John Clarke recount the history of their milestone discovery, which today won the Nobel Prize in Physics go.nature.com/4gVswyS

Quantum Josephson junction circuits and the dawn of artificial atoms - Nature Physics

In 1985, experiments revealed the quantum behaviour of a macroscopic degree of freedom: the phase difference across a Josephson junction. The authors recount the history of this milestone for the development of superconducting quantum circuits.

go.nature.com

We’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy. mikeinmemoriam.sciencesconf.org

Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics. Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri! www.biorxiv.org/content/10.1...

Regulation of epithelial tissue homeostasis by active trans-epithelial transport

Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...

biorxiv.org

As railways enter their third century of service, research must support their renaissance for more-sustainable travel that supports human development go.nature.com/3If7jTK

Make trains great again — for the sake of people and the planet

As railways enter their third century of service, research must support their renaissance for more-sustainable travel that supports human development.

go.nature.com

Science isn’t really moving towards equity; institutions are just perfecting the appearance of equity. We need to build an alternative system, says Dolors Armenteras go.nature.com/4nzGhp9

Equity in science is a beautiful lie — and I’m done pretending

Science isn’t really moving towards equity; institutions are just perfecting the appearance of equity. We need to build an alternative system.

go.nature.com

This comment in @natnano.nature.com is well worth a read ⚛️🧪

Nature Nanotechnology@natnano.nature.com · 11mo ago

Tianxiang Ma, Valeriia Grudtsyna, Robin V. B\"olsterli, Amin Doostmohammadi: Cellular Flow Architecture Exposes the Hidden Mechanics of Biological Matter https://arxiv.org/abs/2508.17974 https://arxiv.org/pdf/2508.17974 https://arxiv.org/html/2508.17974

📢 Institut Jacques Monod Seminar 📅 September 11th 📍 Institut Jacques Monod Invited by @bladoux.bsky.social / @rmmege.bsky.social 's Lab , Stephanie Ellis ( @maxperutzlabs.bsky.social ) give the IJM Seminar "Understanding mosaic tissue dynamics through cell competition. " ➡️ buff.ly/V6LaKMz

📢 PhD Thesis defense 📅 September 11th 📍 Institut Jacques Monod Andreas Schoenit @andreasschoenit.bsky.social ( @bladoux.bsky.social / @rmmege.bsky.social Lab) will defend his PhD thesis "Mechanical forces in cell competition and epidermal stratification" More informations ➡️ buff.ly/yhtJMsu

Want to test your multicellular system? I have created a GitHub repository, ‘3D_SurfProps’, where you can download the MATLAB codes of our 3D surface analysis method: 👉 github.com/Julia-Eckert... Any questions, suggestions, or ideas for improvements? Please DM or email me. Have fun testing!

GitHub - Julia-Eckert/3D_SurfProps: These MATLAB scripts determine the nematic orientation field on the entire surface of 3D tissues of arbitrary shape, based on z-stack images, identify topological d...

These MATLAB scripts determine the nematic orientation field on the entire surface of 3D tissues of arbitrary shape, based on z-stack images, identify topological defects, and quantify signals of f...

github.com

Now published in @natcomms.nature.com! 🥳 👉 rdcu.be/eATn3 We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.

To what extent does crowding modulate diffusion across the cytoplasm? Thrilled to contribute to this study alongside O. Destrian, M. Chabanon, and B. Goyeau! www.biorxiv.org/content/10.1...

Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion

Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is known to strongly alter macromolecule mobility, how cytop...

biorxiv.org