@sidchop.bsky.social explains why we need to re-evaluate how we think about antipsychotics and their effects on the brain.
Yueyue Lydia Qu
@lydiaquq.bsky.social
PhD Candidate at Yale Psychology | WashU '21 | Fan of rock music | 🇨🇳🇸🇬🇺🇸
In our latest episode of The Biological Psychiatry Podcast, we sit down with Dr. @sidchop.bsky.social from @orygen.org.au and the @unimelb.edu.au to discuss his latest work distinguishing the effects of psychotic illness and antipsychotic medication on the brain.
Differential Effects of Psychotic Illness and Antipsychotics on the Brain
In this episode of The Biological Psychiatry Podcast, Dr. Elvisha Dhamala sits down with Dr. Sidhant Chopra from Orygen and the University of Melbourne to discuss his recent paper published in Biologi...
thebiologicalpsychiatrypodcast.riverside.com
The CATS Lab is moving to Columbia next year, and I am recruiting a PhD student this cycle to start Fall 2027 in the Department of Psychology. Learn more about how to apply here: psychology.columbia.edu/content/prep... I am also recruiting a postdoc and staff for 2027. More info coming soon!
Preparing to Apply | Department of Psychology
psychology.columbia.edu
🧠 New work showing prominent and widespread 𝘪𝘯 𝘷𝘪𝘷𝘰 pre-synaptic terminal reductions in people with schizophrenia.🧠 nature.com/articles/s41... Strongest effects in left hemisphere, but synaptic loss didn't track with MRI grey matter alterations, but did align with..👇1/4
Widespread synaptic density loss in schizophrenia follows molecular and network architecture - Molecular Psychiatry
Molecular Psychiatry - Widespread synaptic density loss in schizophrenia follows molecular and network architecture
nature.com
Preprint alert! 🧠 Using movie-watching fMRI and NLP, we show that prior social impressions shape how new social information is processed and updated over time, while moments of sudden insight ("aha"!) accompany transient shifts in brain activity that predict impression updates. (1/10)
biorxiv.org
A new framework reframes depression not as a disorder of negative thoughts but of cognitive flow. It proposes that depressed thinking is stuck, slow, and narrow, and treatments restoring the brain's ability to move fluidly between ideas may be key to recovery.
Facilitating Thought Progression: A Neurocognitive Framework Linking Thought Dynamics and Mood Disorders
Mood and thought are tightly coupled, but the mechanisms linking them are not understood. This link is particularly important when considering mood disorders such as depression. We propose the…
biologicalpsychiatryjournal.com
Anxiety and anhedonia may distort the brain's model of the world in opposite ways. Anxious people overestimate how rapidly threatening environments change, while anhedonic people underestimate change, potentially fueling hypervigilance and hopelessness respectively.
Anhedonia and Anxious Arousal are Associated with Distinct Expectations about the Statistics of a Volatile Environment
The brain is believed to construct a generative model of the environment, updated via differences between predictions and incoming sensory evidence (i.e., prediction errors). Uncertainty can arise at…
bpsgos.org
I finally got to watch this stunningly clear explanation of transformers from the amazing Idan Blank. I agree with Ev, Idan is the best teacher I know. This lecture is a gift to the field. Thank you Idan! www.youtube.com/watch?v=cGMn...
How Transformers Work: A Detailed, Conceptual Explanation (No Coding / Math)
YouTube video by IbanDlank
youtube.com
Ev Fedorenko@evfedorenko.bsky.social · 6mo agoFrom maybe the best teacher I know: Idan Blank explains transformers in a super intuitive and fun way!
Our new paper on brain networks engaged during imagining is out now in Neuron! Here is a download link (free for 50 days): authors.elsevier.com/c/1msNE3BtfH... Congratulations to Nate Anderson for leading this work @rementurus.bsky.social 🧵
Rodrigo Braga@rodbraga.bsky.social · 2y ago🚨 🧠 We have a new preprint out where we studied which brain networks are engaged during mental imagery and self-generated thought. We used a precision fMRI approach along with multidimensional experience sampling (mDES) to get trialwise self-reports from each participant about what they imagined.
Now out in Psychological Medicine! We identified lifetime exposures to humiliation and entrapment, as well as frontoparietal-left cerebellar RSFC, as correlates of adolescent anxiety and depression symptoms across three time points. Link: doi.org/10.1017/S003...
Life experiences of humiliation, entrapment, and frontoparietal-cerebellar connectivity predict adolescent anxiety and depression symptoms | Psychological Medicine | Cambridge Core
Life experiences of humiliation, entrapment, and frontoparietal-cerebellar connectivity predict adolescent anxiety and depression symptoms - Volume 56
doi.org
I couldn't find a tool to plot different #neuroimaging data in one consistent style, so I made one! Meet yabplot (yet another brain plot) - a #Python package for (sub)cortex & tracts.🧠 - Simple API - Built-in atlases - Custom atlas support 🔗 github.com/teanijarv/ya... (drop a ⭐️!)
Looking for a post-bac RA position focused on the brain bases of affective and psychotic illness? @holmeslab-bhi.bsky.social is hiring! @cahbir.bsky.social @rutgersbhi.bsky.social @rutgersu.bsky.social @sobp-org.bsky.social @hitop-system.bsky.social @ohbmofficial.bsky.social
Now out in Plos Computational Biology! We identified a generalizable neural signature of emotional arousal across contexts and individuals during movie watching. work with the best team: @hayoungsong.bsky.social @Zihan Bai @monicarosenb.bsky.social @ycleong.bsky.social dx.plos.org/10.1371/jour...
Dynamic brain connectivity predicts emotional arousal during naturalistic movie-watching
Author summary This study explores how the brain represents two key dimensions of emotional experience: valence (how positive or negative an experience feels) and arousal (the level of emotional activ...
dx.plos.org
New preprint 🎉: How do episodic memory, emotions, and schemas for caregiver experiences come together in kids’ brains and verbal recall? Check out our new results showing how past and present childhood experiences shape perception and memory for movies: www.biorxiv.org/content/10.1...
Past and present caregiving experiences impact prefrontal connectivity and recall for attachment-schema narratives
We investigated how past and current caregiving experiences impacted emotional event processing by examining inter-subject functional correlation in 7- to 15-year-olds during narrative movies depictin...
biorxiv.org
Updated preprint for those who might be interested: doi.org/10.1101/2024...
Longer scans boost prediction and cut costs in brain-wide association studies
A pervasive dilemma in brain-wide association studies (BWAS) is whether to prioritize functional MRI (fMRI) scan time or sample size. We derive a theoretical model showing that individual-level phenot...
doi.org
Thomas Yeo@bttyeo.bsky.social · 2y agoThanks to everyone's feedback, we have updated our calculator to optimize sample size N & scan time T for fMRI studies: leonoqr.github.io/ORSP_Calcula... The first new feature is that users can explore how different N & T leads to different accuracy, e.g., N=1000 & T=30min => 81% max accuracy. 🧵
Thanks to everyone's feedback, we have updated our calculator to optimize sample size N & scan time T for fMRI studies: leonoqr.github.io/ORSP_Calcula... The first new feature is that users can explore how different N & T leads to different accuracy, e.g., N=1000 & T=30min => 81% max accuracy. 🧵
PsyPost covered @lydiaquq.bsky.social's new paper linking internalizing/externalizing symptoms to distinct features! Check it out ⬇️ 🖇️https://www.psypost.org/scientists-identify-distinct-brain-patterns-linked-to-mental-health-symptoms #SciComm #Neuroscience
PsyPost@psypost.bsky.social · last yr.A new study finds that brain connectivity patterns can predict different types of mental health symptoms, with distinct features linked to internalizing and externalizing behaviors across development.
David is a wonderful mentor and a fantastic human being!! Many congrats :)
David Baranger@davidbaranger.bsky.social · 2y agoThe BEAR Lab will be opening it's doors in July at the Medical College of Wisconsin, and we are looking for our first Research Tech! This position will help with funded MRI studies looking at the brain and alcohol use. More info: bearlab.science/contact/ #neuroscience #psychology #sciencejobs
Interested in #MRI and #psychiatry? Our lab is hiring a research assistant (@holmeslab-bhi.bsky.social)! Please RT and share. @geneticssociety.bsky.social @ohbmofficial.bsky.social @sfnjournals.bsky.social @pgcgenetics.bsky.social @hitop-system.bsky.social @blackinneuro.bsky.social
Holmes Lab – Rutgers Department of Psychiatry
holmeslab.rutgers.edu
I'm thrilled to share that my graduate school project was just published in Nature Mental Health! We found that resting-state functional network predictors are more similar within vs between categories of internalizing and externalizing behavior in children (ABCD), adolescents (HBN) and adults (HCP)
Avram Holmes@avramholmes.bsky.social · 2y agoNew @holmeslab-bhi.bsky.social paper by Lydia Qu. Here, we map shared and unique brain features for individual variation in internalizing and externalizing across development. w/@bttyeo.bsky.social, @elvisha.bsky.social, @carrisacocuzza.bsky.social, and many others. www.nature.com/articles/s44...