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Spiros Makris

@makris1.bsky.social

Postdoc @actonlab @LMCB_UCL @UCL |Stromal Immunology|

1 Posts102 Follower113 Folgt
Spiros Makris@makris1.bsky.social · last yr.

Our latest paper is finally out! We are showing the significance of the podoplanin/CLEC-2 signaling axis beyond controlling cellular mechanics and actomyosin contractility. #fibroblasts #podoplanin #stroma #inflammation @actonlab.bsky.social www.cell.com/cell-reports...

Lymph node fibroblast phenotypes and immune crosstalk regulated by podoplanin activity

Makris et al. show that podoplanin regulates the transcription profile of lymph node fibroblasts. Podoplanin deletion drives inflammation, disrupts lymph node architecture, and attenuates stromal/immu...

cell.com

Nature Reviews Immunology@natrevimmunol.nature.com · last yr.

NEW @preprintclub.bsky.social Journal Club of @biorxiv-immuno.bsky.social paper by @makris1.bsky.social @actonlab.bsky.social showing that loss of podoplanin in fibroblastic reticular cells results in decreased antibody levels and smaller germinal centres after immunization

Podoplanin mediates stromal–immune crosstalk in the lymph node - Nature Reviews Immunology

A preprint by Makris et al. shows that podoplanin is a key regulator of the functions of fibroblastic reticular cells in lymph nodes, by modulating interactions with immune cells.

nature.com