A pleasure to contribute to this brilliant work by Tim Halim's group @cruk-ci.bsky.social www.science.org/doi/10.1126/...

ILC2s regulate a fibroblast progenitor niche in the pancreas

Local fibroblast development and densities influence organ health and disease, although it remains unclear how tissue fibroblast topography is controlled in situ. Here, we defined Group 2 innate lymph...

science.org

Cancer Research UK Cambridge Institute@cruk-ci.bsky.social · last mo.

Researchers from the Halim Group have discovered that cancer can "hijack" a cellular repair partnership in the pancreas to help tumours grow. Read more in the new paper: www.science.org/doi/abs/10.1...

Proud to contribute to a seminal study in #ScienceMagazine revealing the importance of #ILC2-#Pi16+ #Fibroblast interactions in the pancreas. Forever grateful to @timotheus_halim & congrats to the co-authors! tinyurl.com/fmypdbme buechlerlab.com

ILC2s regulate a fibroblast progenitor niche in the pancreas

Local fibroblast development and densities influence organ health and disease, although it remains unclear how tissue fibroblast topography is controlled in situ. Here, we defined Group 2 innate lymph...

tinyurl.com

Please share your opinions - students, postdocs, group leaders! we're collecting data on the funding and publishing landscape in the UK - following up on data from 3 years ago. Are things improving? or not? please follow the link below and share your thoughts docs.google.com/forms/d/e/1F...

Looking for a home for your immune cell biology paper? Our Academic Editor, Sophie Acton (@actonlab.bsky.social) handles articles on this topic so send your article our way. There are lots of reasons to choose JCS – find out more: journals.biologists.com/jcs/pages/re... #immunology #immunecells

Interested in joining a dynamic, interdisciplinary research department? A call is open for Group Leaders at the UCL Laboratory for Molecular Cell Biology. Please submit your expression of interest by April 13, 2026. Further details here: www.ucl.ac.uk/work-at-ucl/...

*Recruiting new group leaders* The @lmcb-ucl.bsky.social at University College London are looking for outstanding candidates to sponsor for career development fellowships. Fellows would then be assessed for tenured positions at the end of the fellowship term.

Tumor-draining Lymph nodes - Online event next week! follow the link to register On January 13 from 11:30 – 1:00 pm ET, @thelundlab.bsky.social , Dr. Ivan Maillard, @actonlab.bsky.social , & Dr. Burkhard Ludewig will discuss lymph node remodeling in cancer: events.cancer.gov/dcb/tdln #TLDNForums

Laurence Wilson and Martin Bees use high-speed 3D holographic imaging to capture the flagellar beat of single algal cells, revealing changes in the ‘handedness’ of the flagellar shapes at different points in their cycle. #JCSciliaSI journals.biologists.com/jcs/article/...

Tongxiang Chen, Anthi Psoma, Geert van den Bogaart, Harry Warner @rug.nl @novo-nordisk.bsky.social & team discover that phosphorylation of VAMP3 couples IL-6 exocytosis to dendritic cell activation. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

📢 Short talk abstract/scholarship submission ends tomorrow! #KSStromal26 Don't miss out on the biggest #stromal #immunology conference happening in 2026. Register now: keysym.us/KSStromal26

Stromal Immunology in Health and Disease | Keystone Symposia

Join us at the Keystone Symposia on Stromal Immunology in Health and Disease, February 2026, in Banff, with field leaders!

keysym.us

We hiring! Please share this post with your talented ECRs We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome Based at @lmcb-ucl.bsky.social at University College London Apply here: www.jobs.ac.uk/job/DPD418/r...

Lovely trip to @institutcurie.bsky.social this week for student viva. Paris in the sunshine ☀️

We found that the FRC network in lymph nodes requires protrusions to follow ECM scaffolds and to link neighbouring fibroblasts. FRC use MARCKS to generate protrusions, and that PKN2 is the key kinase for these stroma Updated preprint below First round of revisions done doi.org/10.21203/rs....

Dr. Sophie Acton (@actonlab.bsky.social/UCL) is a Cancer Research UK Senior Fellow with an interest in lymphoid tissue biology. At #KSStromal26, she'll be sharing her insights on podoplanin - a molecule that controls DC motility within the lymph node. Register now! Link in bio.

Save the date! Keystone Stromal Immunology meeting, Feb 2-5, 2026 #KSStromal26 1. Scholarships/Short Talk Abstracts: October 7 2. Early Registration: December 3 (Save $200!) 3. Poster Abstracts: January 12, 2026 (11:59 MST) Please share! And reach out if you have any questions. Can't wait!

Pleased to update this - The paper is published in Cell Reports! A long road for this one, the paper grew exponentially and evolved over a couple of years. Thanks to @makris1.bsky.social for sticking with it to untangle all the new data! @cp-cellreports.bsky.social www.cell.com/cell-reports...

Lymph node fibroblast phenotypes and immune crosstalk regulated by podoplanin activity

Makris et al. show that podoplanin regulates the transcription profile of lymph node fibroblasts. Podoplanin deletion drives inflammation, disrupts lymph node architecture, and attenuates stromal/immu...

cell.com

Sophie Acton@actonlab.bsky.social · 2y ago

Our latest preprint! - led by @makris1.bsky.social we find that Podoplanin expression in lymphoid tissue fibroblasts regulated their inflammatory signalling and crosstalk with immune cell populations doi.org/10.1101/2022...

Our latest preprint! - led by @makris1.bsky.social we find that Podoplanin expression in lymphoid tissue fibroblasts regulated their inflammatory signalling and crosstalk with immune cell populations doi.org/10.1101/2022...

Our latest paper is finally out! We are showing the significance of the podoplanin/CLEC-2 signaling axis beyond controlling cellular mechanics and actomyosin contractility. #fibroblasts #podoplanin #stroma #inflammation @actonlab.bsky.social www.cell.com/cell-reports...

Lymph node fibroblast phenotypes and immune crosstalk regulated by podoplanin activity

Makris et al. show that podoplanin regulates the transcription profile of lymph node fibroblasts. Podoplanin deletion drives inflammation, disrupts lymph node architecture, and attenuates stromal/immu...

cell.com

🔬 Calling all researchers! 📢 Submit your research or reviews on myeloid cells for a special collection curated by experts! Dive into the latest on their role in health & disease, and contribute to cutting-edge immunology. 🧬 👉 Learn more & submit: bit.ly/43OULe9

Learn more about UCL's Computational Cell Biophysics MRes by registering for one of our virtual open events on Wednesday 9 April: www.ucl.ac.uk/lifesciences...

MRes Computational Cell Biophysics virtual open events

Join one of our online open day sessions to find out more about UCL's Computational Cell Biophysics MRes.

ucl.ac.uk

Contribute to the latest research on neuroinflammation! 🧠🔬 We’re inviting submissions on microglia, CNS immunopathology, and novel immune interactions in the brain. Submit by June 2025! 📄 Learn more: bit.ly/3XAlsPV

🐟 Did you know the immune system might be linked to the lunar cycle? A new study on freshwater three-spined sticklebacks suggests a tiny endogenous tidal rhythm in immune gene expression! 🌊🔬 Read more in Discovery Immunology 👉 bit.ly/4hMtCMm #Immunology

In their Review, Julien Morival, Anna Hazelwood and Jan Lammerding @lammerdinglab.bsky.social discuss new insights and technological advances in understanding nuclear mechanotransduction. journals.biologists.com/jcs/article/...

Issue 4 is complete Explore our ToC: journals.biologists.com/jcs/issue/13... Our cover image shows the stacked membranous discs which form the outer segments of photoreceptor cells. See article from Mohona Gupta, Gregory Pazour and colleagues: journals.biologists.com/jcs/article/...

NEW @preprintclub.bsky.social Journal Club of @biorxiv-immuno.bsky.social paper by @makris1.bsky.social @actonlab.bsky.social showing that loss of podoplanin in fibroblastic reticular cells results in decreased antibody levels and smaller germinal centres after immunization

And Erika McCartney from Toronto will present a preprint about the effect of Podoplanin expression on the phenotypes and immunoregulatory properties of fibroblasts in lymph nodes. www.biorxiv.org/content/10.1...

Lymph Node Fibroblast Phenotypes and Immune Crosstalk Regulated by Podoplanin Activity

Lymph nodes are uniquely organised niches for immune interactions. Fibroblastic reticular cells (FRCs) facilitate immune cell communication and regulate immune function by producing growth factors, ch...

biorxiv.org

On #WorldCancerDay, we meet with @actonlab.bsky.social where Sophie Acton delves into the interactions between immune cells and support cells in lymph nodes and tumours. She discusses how fibroblasts influence immune responses and their potential in cancer therapy. www.ucl.ac.uk/lifesciences...

Also in Issue 2: - Research Highlights on axon guidance, muscle fibres & EGFR signalling - Meet our Associate Editors, Sophie Acton @actonlab.bsky.social, Pedro Carvalho, @guijacquemet.bsky.social, @ckirchhelle.bsky.social & Aryeh Warmflash - GAG lyases Review journals.biologists.com/jcs/issue/13...

JCS Editor-in-Chief @drmichaelway.bsky.social introduces our new Associate Editors. We are delighted to welcome Sophie Acton @actonlab.bsky.social, Pedro Carvalho, @guijacquemet.bsky.social, @ckirchhelle.bsky.social and Aryeh Warmflash to the JCS team. journals.biologists.com/jcs/article/...

Sophie @actonlab.bsky.social will handle manuscripts on immune cell biology, immunology, tumour microenvironment and lymphoid tissues. You can learn more about Sophie’s research in our Cell Scientist to Watch interview from 2020: journals.biologists.com/jcs/article/...