Seth Coffelt
@coffeltlab.bsky.social
cancer researcher, γδ T cell enthusiast, music listener, former diaper changer, works at @CRUK_SI and @UofGCancerSci
www.cell.com/trends/immun... @coffeltlab.bsky.social
Seven subsets, two fates: mouse γδ T cells in cancer immunity
The importance of γδ T cells in cancer, as defenders against tumorigenesis, was established more than 2 decades ago. Since that time, research using mouse models of cancer has brought to light a nonun...
cell.com
A good moment for people and organisations to abandon their presence on Twitter/X and stop supporting Elon Musk's hate platform was four years ago. The second best moment was two years ago. And then last year. A few months ago: late but still OK. Definitely now. There's no excuse left to stay.
Jasmine Clark will become the first Black woman with a science Ph.D. to serve in the U.S. House of Representatives. https://scim.ag/4dDZe6P
Microbiologist wins Georgia primary for U.S. House seat
Jasmine Clark is set to become the first Black congresswoman with a science Ph.D.
scim.ag
Online now: Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling
Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling
(Immunity 49, 857–872.e1–e5; November 20, 2018)
dlvr.it
If you are interested in PARP inhibitors and history, this might be of interest to you. www.nature.com/articles/s41.... An attempt to cover the work of thousands and their immense contributions to the development of a targeted approach to treating cancers.
Two decades of PARP inhibitor synthetic lethality in cancer - Nature
The past two decades of PARP inhibitor synthetic lethality in cancer is explored.
nature.com
Meanwhile on VE Day, marking the unconditional surrender of right-wing extremism and fascism in Europe.
ICYMI: New online! γδ T cells in colorectal and liver cancer
γδ T cells in colorectal and liver cancer
Nature Reviews Gastroenterology & Hepatology, Published online: 22 April 2026; doi:10.1038/s41575-026-01196-7γδ T cells are an important component of local immune surveillance. This Review discusses their role in colorectal cancer and hepatocellular carcinoma development and provides a detailed overview of their therapeutic potential.
dlvr.it
Doing the periodic cleaning of used plasmid miniprep columns and realized in honor of Earth Day it may be worth reminding you molecular biologists: Plasmid miniprep columns can be cleaned and reused essentially indefinitely! Just add 1 M HCl, soak overnight and wash 3x w/ water. Save $ and plastic
📣We've summarized all there is to know about mouse #gdTcells in cancer and how they relate to humans @immunowolf.bsky.social #AbhiramMallu #NataliePhinney check it out here: authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
Check out this lineup 🎉 Join us the last week of June for 100% cancer immunology
Cancer Research UK Scotland Institute@cruk-si.bsky.social · 5mo ago📣Register now for the Beatson International Cancer Conference 2026 ‘From Tumour Genesis to Metastasis: an immune perspective’ 📅22-25 June 2026 📍CRUK Scotland Institute, Glasgow 🎟️Early Bird registration closes on 1 April 🔗 www.beatsonconference.org #BICC2026 #CancerResearch #Immunology
Portraits of some of the researchers that The Regime has run off. We are losing so many excellent researchers.
The people — and research — lost in the NIH exodus | CNN
Sylvia Chou, 51
edition.cnn.com
Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model #gdTcells @coffeltlab.bsky.social
Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model
In lung cancer, airway macrophages are modulated by an unconventional T cell subset, relevant to care for pulmonary comorbidities.
science.org
*Recruiting new group leaders* The @lmcb-ucl.bsky.social at University College London are looking for outstanding candidates to sponsor for career development fellowships. Fellows would then be assessed for tenured positions at the end of the fellowship term.
Check out this lineup 🎉 Join us the last week of June for 100% cancer immunology
Cancer Research UK Scotland Institute@cruk-si.bsky.social · 5mo ago📣Register now for the Beatson International Cancer Conference 2026 ‘From Tumour Genesis to Metastasis: an immune perspective’ 📅22-25 June 2026 📍CRUK Scotland Institute, Glasgow 🎟️Early Bird registration closes on 1 April 🔗 www.beatsonconference.org #BICC2026 #CancerResearch #Immunology
Detection of metastatic burden is a task for CODA, which maps organs in 3D and at single-cell resolution. More here: www.biorxiv.org/content/10.6...
Join us for our March #GDTcellclub webinar talks with Drs. Judith Wienke (Utrecht) and Monika Wolkers (Sanguine BSF) on March 19 at 12pm NY time. Zoom ID: 958 9051 7066/ passcode 369081 nyulangone.zoom.us/j/9589051706...
Helpful update into UKRI and research council funding changes from Zoe Kleinman @zsk.bsky.social But please more focus on 2 things... 1) Immediate effects (eg funding decisions expected in March) 2) Likely disproportionate effects on early career scientists www.bbc.co.uk/news/article...
UK’s £8bn research fund faces “hard decisions” as it pauses new grants
UKRI boss Ian Chapman said it had been told by the government to
bbc.co.uk
BREAKING: Over 680 members of the National Academy of Sciences, Medicine, and Engineering have endorsed articles of impeachment against RFK Jr. (1/2 🧵)
More than 7,800 research grants terminated or frozen. Some 25,000 scientists and personnel gone from agencies. Proposed budget cuts of 35% — amounting to US$32 billion. These are just a few of the ways Donald Trump has downsized and disrupted US science go.nature.com/4sTPWdp
US science after a year of Trump: what has been lost and what remains
A series of graphics reveals how the Trump administration has sought historic cuts to science and the research workforce.
go.nature.com
Climate change news The three seasons in the UK are now Easter, summer and Christmas.
Matthias Eberl@eberlmat.bsky.social · 7mo agoJust to say that my local Morrisons has started to sell chocolate Easter eggs. Happy New Year.
📢Are you a talented #ECR looking to start your independent lab in state-of-the-art cancer research facilities? Join the CRUK Scotland Institute & @uofgcancersciences.bsky.social as a Junior Group Leader! 👉Apply here: www.crukscotlandinstitute.ac.uk/careers/grou... 📅Closing date: 10 October 2025
Was "Let's make our universities financially dependent on overseas tuition fees." Then "Let's make it more difficult and less attractive for overseas students to come to the UK." Now "Oops."
UK study visa applications drop as immigration changes hit universities
Fees from international students are vital in offsetting long-term funding squeeze
ft.com
Super proud to see our work featured on the cover of @emboreports.org today. Many thanks to @pedromics.bsky.social for this beautiful interpretation and depiction of our story. Read the associated paper here: www.embopress.org/doi/full/10....
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...
embopress.org
EMBO Reports@emboreports.org · 11mo agoThe first September issue is live. www.embopress.org/toc/14693178... The cover features work by Cassie Clarke @cassiejclarke.bsky.social @cruk-si.bsky.social and co-workers showing that UPP1 supports #metastasis by altering #immune and ECM landscapes. -> www.embopress.org/doi/full/10....
check out our new commentary on 2 recently published papers about #gdTcells in breast cancer www.sciencedirect.com/science/arti...
γδT cells and breast cancer: wicked allies
Metastatic disease and therapy resistance pose significant challenges in the treatment of breast cancer. Recent studies by Rozalén et al. and Petroni …
sciencedirect.com
No one has done more damage to public health and trust in science and medicine than Andrew Wakefield. 26 years after his wrong and fraudulent paper people are still spouting his nonsense about an alleged link between vaccines and autism. The study was debunked countless times. There is no link.
Aaron Rupar@atrupar.com · 11mo agoMARKWAYNE MULLIN: Why wouldn't we look at vaccines and autism? HUNT: We have looked at it and the studies show there is no connection MULLIN: So we shouldn't look at it again?
MO Gov Mike Kehoe is calling a special session to gerrymander the 5th District which encompasses Kansas City. He is specifically violating Section 2 of the Voting Rights Act, which bans any voting practice that denies or weakens the power of a racial minority to elect its preferred candidates.
Proud to share an exciting study on the metabolic changes observed in the body before the spread of breast cancer. This seminal work could pave the way for early interventions and more positive outcomes for patients. Congratulations to all involved! www.embopress.org/doi/full/10....
Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports
imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...
embopress.org
