Marc van Oostrum
@marcvoo.bsky.social
Brain proteome | synapse diversity | spatial proteomics | systems biology | @alleninstitute.org https://bit.ly/MvO
Cool proteomics work showing how similar organoid synapses are to in vivo synapses. Great job Stefano and team!
Stefano Giandomenico@sgiando.bsky.social · last wk.Can a brain organoid grown in a dish build synapses that resemble the real thing at the molecular level? 🧠 We grew mouse forebrain organoids for 35 days and compared their synaptic proteome to that of the adult mouse cortex 🧪 www.biorxiv.org/content/10.6... 🧵 1/5
Can a brain organoid grown in a dish build synapses that resemble the real thing at the molecular level? 🧠 We grew mouse forebrain organoids for 35 days and compared their synaptic proteome to that of the adult mouse cortex 🧪 www.biorxiv.org/content/10.6... 🧵 1/5
🎉 We’re delighted to announce Professor Erin Schuman, will become Director of the UCL Queen Square Institute (@uclqsion.bsky.social) from 1 Jan 2027. www.ucl.ac.uk/news/2026/ap...
Delighted to share our discoveries about one of the brain's neurotransmitter systems: www.biorxiv.org/content/10.6... Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1
biorxiv.org
We are delighted to announce that Paola Picotti has been awarded the Otto Naegeli prize for biomedical research! otto-naegeli-preis.ch
Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA www.science.org/doi/10.1126/... co-first with: @andschwarz.bsky.social with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more 🧵 0/6 #MolBio 🧪
Autismus - Neuronale Besonderheiten und neue Behandlungswege #EinblickeBiozentrum by @scheiffelelab.bsky.social December 16, 2025. Erfahren Sie, wie das Wissen über Veränderungen neuronaler Netzwerke bei Autismus für die Entwicklung neuer Therapieansätze verwendet wird. ow.ly/Wkme50RbjZc
Thank you to 250+ participants, our keynote speakers, and the Event Forum team for an inspiring Swiss Dementia Forum.
Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids. Link: www.biorxiv.org/content/10.1...
🎉 Huge congratulations to @MpiBrain director Erin Schuman @erin-schuman.bsky.social on receiving the 2026 Nakasone Award for her groundbreaking work on the function and plasticity of neuronal synapses! 🧠 @hfspo.bsky.social #neuroscience #HFSP #NakasoneAward 👉 bit.ly/4m6g40P
Erin M. Schuman Wins 2026 Nakasone Award
bit.ly
Congratulations! The new Advanced Grant winners are great news. But yet again, many scientists - around 260 - with ground-breaking ideas were rated as excellent, but remained unfunded due to a lack of funds at the ERC. Hope that more funding will be available in the future!
European Research Council (ERC)@erc.europa.eu · last yr.📣 Good news: 281 top researchers have just won ERC Advanced Grants! The new funding, worth nearly €721 million, is part of the 🇪🇺 EU’s #HorizonEurope programme. Find out more 👉 europa.eu/!JYKxkD #ERCAdG #FrontierResearch @ec.europa.eu
We are accepting applications for a PhD opportunity at @scilifelab.se this is part of a MSCA Doctoral Network on the topic of metabolic regulation of genome function and cell identity. A EU funded generous fellowship is offered with possibility of industry experience. Apply here:
PhD project in METABOLIC REGULATION OF GENOME FUNCTION AND CELL IDENTITY – Ilaria Piazza Laboratory
thewittysquare.eu
@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...
Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation
Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…
sciencedirect.com
"Exploring brain circuits, one cell type - or more - at a time" www.cell.com/neuron/fullt... This one is for all the #ChandelierNeuron fans out there #sciArt #sciComm #neuroscience #neuroskyence
🎉 Big congrats to @marcvoo.bsky.social for winning the Best Talk Prize sponsored by Proteomes at the Annual Swiss Proteomics Meeting 2025! 🎉Congratulations to all other prize winners！ 👏 Warm congratulations to the organizers on the successful completion of the event! #proteomes #proteomics
Glad to see our new paper finally out! We show how the GPR158 receptor controls synapse maturation and function by silencing an intrinsic inhibitory mechanism. authors.elsevier.com/a/1l7HS5Sx5g... Work from Ben Verpoort and colleagues, with special thanks to our collaborators.
We are happy to share our new work on glutamine addiction in cancer cells. By characterizing the exchange rate and dynamic metabolite response to extracellular glutamine deprivation, we shed light on long standing questions about glutamine addiction. www.biorxiv.org/content/10.1...
The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility.
Cancer cells develop unique addictions to nutrients offering attractive opportunities for clinical intervention. However, how cancer cells orchestrate and benefit from metabolic rewiring remain fundam...
biorxiv.org
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - @pedrobeltrao.bsky.social @imsb-eth.bsky.social @opentargets.org go.nature.com/3Z1q0PM
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology
Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.
go.nature.com
Teamwork is crucial for proteins. Little is known, however, about which protein teams are actually active in which tissues. A new large-scale study by systems biologists at ETH Zurich is now redrawing the map. ethz.ch/en/news-and-...
Understanding which proteins work together
Teamwork is crucial for proteins. Little is known, however, about which protein teams are actually active in which tissues. A new large-scale study by systems biologists at ETH Zurich is now redrawing...
ethz.ch
Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights: www.nature.com/articles/s41...
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology
Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.
nature.com
New Preprint out ! The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator www.biorxiv.org/content/10.1... Lead by: @sgiando.bsky.social with: @muellermara.bsky.social , @erin-schuman.bsky.social , @marcvoo.bsky.social and many more Short thread below 🧵1/4
50% of all proteins localize to multiple locations - but check this out, a proteasome maturation factor that acts as nexus linking protein turnover with RNA biogenesis! Congrats Stef & @erin-schuman.bsky.social from @mpibrain.bsky.social ! www.biorxiv.org/content/10.1...
The proteasome maturation factor POMP moonlights as a stress-induced transcriptional regulator
Proteostasis - the maintenance of proteins at proper concentrations, conformations, and subcellular locations - is essential for cellular function and is governed by tightly regulated protein synthesi...
biorxiv.org
On the value of exploration of nature and "fishing" expeditions. Hypothesis driven research is important but so is simply observing, measuring and looking for cool new unexpected things.
Luis Javier Galindo@luisjagago.bsky.social · last yr.First study from the lab is out! We describe ApuRs, a new family of microbial rhodopsins unique from apusomonads. ApuRs represent the first anion-conducting rhodopsin channels that can be controlled by UV light, offering potential as new optogenetic tools. #protistsonsky doi.org/10.1101/2025... 👇
❗Serious consequences for the Swiss economy and society – the SNSF urges the abandonment of the proposed cuts to research funding in "Relief Package 27," as they threaten the country's innovative capacity and competitiveness. ➡️
The SNSF urges against cuts
In its statement on "Relief Package 27", the SNSF speaks out against the proposed annual cuts of 10 percent.
buff.ly
❗Gravierende Folgen für die Schweizer Wirtschaft und Gesellschaft: Der SNF fordert den Verzicht auf die im «Entlastungspaket 27» vorgesehenen Kürzungen bei der Forschungsförderung. Diese würden die Innovationskraft und Wettbewerbsfähigkeit des Landes gefährden. ➡️https://buff.ly/eorZPvl
snf.ch
Postdoc opportunity in the heart of Europe! Check out the flyer below. Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits.
My lab at CUHK (QS: 36th) is hiring! We are looking for motivated Research Assistants, PhD students (urgent🚨) and Postdocs who love solving problems. To understand the mysterious brain, we use a range of fun techniques. Please spread the word and get in touch if you are interested!
