Can a brain organoid grown in a dish build synapses that resemble the real thing at the molecular level? 🧠 We grew mouse forebrain organoids for 35 days and compared their synaptic proteome to that of the adult mouse cortex 🧪 www.biorxiv.org/content/10.6... 🧵 1/5

🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET

Our work investigating the cooperation between gene expression machines is now online @cellpress.bsky.social. Check it out if you're interested in high-throughput #cryoET, transcription and translation, or using structural biology to quantify gene expression in cells! 🔬 www.cell.com/cell/fulltex...

Single-cell visual proteomics of a minimal bacterium reveals structural coordination of gene expression machineries

Cryo-electron tomography (cryo-ET) resolves and quantifies an almost complete view of bacterial translation, revealing how gene expression machineries coordinate across the processes of transcription,...

cell.com

The singular job of all known ribosomes: synthesizing protein. Enter the malaria parasite. In our new work, we show that Plasmodium evolved an entire new kind that does just the opposite - inhibit mRNA translation. www.biorxiv.org/content/10.6...

Happy that our research on mRNA localization, synaptic diversity and local protein synthesis in layer 1 is now out in Cell Reports! 🧬🧠 Read it in full here 👉 doi.org/10.1016/j.ce... and browse the data here 👉 syndive.org @cp-cellreports.bsky.social @mpibrain.bsky.social

Teresa Spanò@teresaspano.bsky.social · 10mo ago

I’m excited to share my PhD work on localized mRNAs and protein synthesis in cortical layer 1 on bioRxiv! www.biorxiv.org/content/10.1...

Delighted that our story on chromatin architecture inside human cells is now published — the last chapter of my PhD. It was a pleasure working with @sergiocruzleon.bsky.social, @johannesbetz.bsky.social, and everyone involved. #teamtomo www.nature.com/articles/s41...

Molecular architecture of heterochromatin at the nuclear periphery of primary human cells - Nature Communications

The 3D organisation of chromatin inside a human cell is still not fully resolved. Here the authors reveal that in situ cryo-ET resolves individual nucleosomes and predicts DNA linkers, thus showing th...

nature.com

Max Planck Institute of Biophysics@mpibp.bsky.social · 3mo ago

How do 2 meters of DNA fit inside a nucleus you can barely see? 🧬 Our new study mapped individual nucleosomes inside human cells.

We are sharing a tool developed initially for internal use called VOSE (Volume Operations Simplified Edition) today. It is written specifically to work in ChimeraX (version 1.5+), with no additional libraries necessary to be installed. github.com/jparmachelab...

GitHub - jparmachelab/ChimeraX-VOSE: ChimeraX Volume Operations Simplified Edition

ChimeraX Volume Operations Simplified Edition . Contribute to jparmachelab/ChimeraX-VOSE development by creating an account on GitHub.

github.com

Komm’ am 12. Juni auf die Night of Science✨! Erlebe, wie aus Stickstoff leckeres Eis🍦wird und welche Aufgaben verschiedene Proteine in unserem Körper übernehmen! Erfahre in Vorträgen und bei einer Elektronenmikroskopie-Tour 🔬 mehr über unsere Forschung! Infos: 👉 www.biophys.mpg.de/de/night-of-...

We're happy to announce our new preprint! 🐸 easymode: general pretrained networks for cellular cryo-ET. Segment ~20 cellular features – ribosomes, microtubules, mitochondria, nuclei & more – with zero model training. 🔗 doi.org/10.64898/202... 🧵👇

Sub-cellular chemical mapping using correlated cryogenic electron and mass spectrometry imaging online @natmethods.nature.com, led by Hannah Ochner, collaboration with @catfranco.bsky.social and @kiranrpatil.bsky.social labs doi.org/10.1038/s415...

Easymode: general pretrained networks for cellular cryo-ET enable flexible approaches to subtomogram averaging https://www.biorxiv.org/content/10.64898/2026.05.19.726344v1

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

🎉 We’re delighted to announce Professor Erin Schuman, will become Director of the UCL Queen Square Institute (@uclqsion.bsky.social) from 1 Jan 2027. www.ucl.ac.uk/news/2026/ap...

The peer reviewed version is out. Our study suggests this process is not limited to a single dimer architecture: we identified an additional dimeric arrangement, pointing to greater structural diversity in stress-induced ribosome hibernation-like states. doi.org/10.1093/nar/...

rRNA expansion segments mediate ribosome dimerization as a conserved stress response

Abstract. Inhibition of messenger RNA translation is a common feature in proteostatic stress cellular responses. Puromycin, a widely used compound for stud

doi.org

@qiangguo.bsky.social · 7mo ago

Excited to share our new study: rRNA expansion segments are not passive structural elements — they mediate hibernating ribosome interfaces and reshape translation under stress. www.biorxiv.org/content/10.6...

That’s a wrap on our @embo.org #cryoFIB & #cryoET course! It was an incredible week of hands-on learning, collaboration, and shared expertise, made possible by dedicated organizers, incredible trainers, and an engaged group of participants.

An exciting PhD opportunity investigating ribosome hibernation in cancer is available in my lab, in collaboration with Steffen Scholpp and Ke Li! The interdisciplinary project will span cell biology, structural biology, and AI-guided modelling. Please get in touch if you are interested!

We’ve kicked off our @embo.org Practical Course on #cryoFIB & #cryoET! Participants from around the world are joining us this week for hands-on training, from lamella milling to tomogram reconstruction 🔬

napari needs your help! Has napari helped you make cool and groundbreaking discoveries? We'd love to highlight that in our docs. Please tell us about it! You can fill in this survey: napari.typeform.com/to/vTCKeTKv and/or, as ever, drop by our chat room or meetings: napari.org/dev/community/ 🙏

We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo. #OpenSoftwareAcceleratesScience

Excited to share our new study: rRNA expansion segments are not passive structural elements — they mediate hibernating ribosome interfaces and reshape translation under stress. www.biorxiv.org/content/10.6...

Come visit our @mpibp.bsky.social booth at the @biophysicalsoc.bsky.social #bps2026 meeting in San Francisco! We’re looking forward to chat about our research, PhD opportunities, and international career paths! 🥳 We’d love to connect and take your #cellfie! 🦠 Find us in booth 630! #imprs #imprs_cbp

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes pubmed.ncbi.nlm.nih.gov/41712727/ #cryoEM

Out now in @science.org Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes | Science www.science.org/doi/10.1126/...

Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes

Cells down-regulate protein synthesis when stressed to conserve energy and shift resources toward repair. We found that in some mammalian cells, including neurons, stress also resulted in the formatio...

science.org

Ribosomes in pairs: A survival strategy inside stressed cells. When nutrients drop or temperatures shift, cells switch to survival mode. New work by @erin-schuman.bsky.social & colleagues shows that inactive ribosomes pair up via a ribosomal RNA link @andschwarz.bsky.social @muellermara.bsky.social

Mammalian cells form hibernating disomes akin to those in bacterial cells - but connected via ribosomal RNA www.science.org/doi/10.1126/... co-first with: @andschwarz.bsky.social with: @lea-dietrich.bsky.social, @sgiando.bsky.social, @erin-schuman.bsky.social and many more 🧵 0/6 #MolBio 🧪

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET

We are very excited to see this work out in its final form at Ultramicroscopy! Knife edge measurements of beam shapes and improved scanned versus shaped beam material removal comparisons. Find the OA article here: doi.org/10.1016/j.ul...

Sven Klumpe@svenklumpe.bsky.social · last yr.

Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...

What a great example of collaborative science enabled by people sharing things early on. Well done @lifeonthewedge.bsky.social and others!

Ricardo D. Righetto@lifeonthewedge.bsky.social · 9mo ago

This one was quite the journey! The paper describing the #ChlamyDataset is finally out and on the cover of Mol Cell! This beautiful rendering made by co-author @jessheebner.bsky.social and Holly Peterson shows an instance of mitochondrial fission found in the dataset 😍 [Maybe long thread ahead]

Did you know we’re hosting the EMBO Practical Course on Cryo-FIB & Cryo-ET in April 2026? ❄️ We invite early career researchers and facility scientists to join us in Frankfurt and meet the leading experts in cryo-FIB/SEM and cryo-ET! 🔗 Apply by Dec 8: meetings.embo.org/event/26-in-...