MargolisLab
@margolislabnyu.bsky.social
Margolis Lab | NYU Pain Research Center 🧠💩 Discovering how gut signaling impacts brain & GI disorders. Exploring the role of serotonin in gut-brain interaction, DGBI, neurodevelopmental disorders, and visceral pain. PI: @karapedsgastrodoc.bsky.social
🎉 Congratulations to Chalystha and Rahi from the Margolis Lab on their achievements at the 2026 Annual Molecular Pathobiology Innovative Research Symposium (AMPIRS)! Chalystha won 3rd Place for her 3-minute flash talk Rahi won 3rd Place for her poster presentation @karapedsgastrodoc.bsky.social
ConGRADulations, Mariam! 🎓 It has been a pleasure having Mariam in the Margolis Lab through NYU Dentistry's TRIP&ICE program. We are so proud of all she has accomplished and wish her the very best in her next chapter! @karapedsgastrodoc.bsky.social @chalysthalee.bsky.social
More highlights from our amazing team at the NYU Pain Research Center Symposium! We're proud of our team's contributions and grateful for a fantastic day of science, collaboration, and discovery.
The Margolis Lab was proud to be represented by six poster presenters at the 2026 Pain Research Center Symposium! Congratulations to: Sarah, Daniel, Chalystha, Lin, Rahi, Taeseon Great job to everyone who presented and contributed to a fantastic day of science! @karapedsgastrodoc.bsky.social
Highlights from the 2026 Pain Research Center Symposium! Dr. Kara Margolis presented: “Compartmental Serotonergic Signaling in Gut–Brain Health: Clinical Implications for Mood and Abdominal Pain” Thanks to everyone for a great day of science! @karapedsgastrodoc.bsky.social
Congratulations to Haoming on graduating from New York University with a Master of Science in Biology from the Graduate School of Arts and Sciences! 🎓✨ Wishing you all the best in your next chapter, we’re so proud of you! @karapedsgastrodoc.bsky.social
New data from the Julius Lab show that crosstalk between epithelial tuft cells and enterochromaffin cells drives a gut-brain signal that turns parasite sensing into appetite suppression. Cool stuff! @karapedsgastrodoc.bsky.social www.nature.com/articles/s41...
Parasites trigger epithelial cell crosstalk to drive gut–brain signalling - Nature
Paracrine signalling between tuft cells and enterochromaffin cells is a key mode of immune–sensory and gut–brain communication, and accounts for the pattern of gastrointestinal symptoms that occu...
nature.com
In our latest study, we explore how early experiences can shape gut function and pain later in life. Dr. @sarahanajjar.bsky.social breaks it down 👇
Dr. Lin Hung from our lab received the 2026 American Gastroenterological Association Research Scholar Award for her project on linking GI-derived oxytocin and serotonin to treat DGBI pain. This prestigious award supports early-career researchers pursuing independent careers in digestive diseases.
We’re excited to launch a new series of posts and videos from the Margolis Lab 🎥 Stay tuned.👀 Our first video drops tomorrow! Dr.@sarahanajjar.bsky.social will be sharing insights on our newly published paper. @karapedsgastrodoc.bsky.social
We are thrilled to be at USASP in Philadelphia! Looking forward to a week of great science. @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social @sdavidson.bsky.social @elisadamo.bsky.social @tonelloraquel.bsky.social @mariafialho.bsky.social @pazduran.bsky.social @badrsokrat.bsky.social
Don’t miss Dr. Kara Margolis’ talk this afternoon at #USASP2026 on serotonin signaling in the gut-brain axis! @karapedsgastrodoc.bsky.social
New from our lab: Untreated maternal depression & early-life stress can rewire gut–brain circuits via enteric + sympathetic pathways, leading to long-term changes in gut motility & pain. www.sciencedirect.com/science/arti... @karapedsgastrodoc.bsky.social @sarahanajjar.bsky.social
Enteric and Sympathetic Nervous System Pathways Mediate Early Life Stress Effects on Gut Motility and Pain: Mechanistic Findings with Human Correlation
Adverse experiences during early life can disrupt gut-brain axis development, but the mechanisms linking early life stress (ELS) to long-term gastroin…
sciencedirect.com
Amazing new article from the Thaiss and Levy labs! These data show that gut microbes drive age-related memory loss by disrupting gut-brain signaling. @christophthaiss.bsky.social @maayanlevy.bsky.social @karapedsgastrodoc.bsky.social www.nature.com/articles/s41...
Intestinal interoceptive dysfunction drives age-associated cognitive decline - Nature
Age-related microbiome changes increase medium-chain fatty acid-producing bacteria, driving GPR84-mediated myeloid inflammation, impaired vagal signalling and hippocampal dysfunction; targeting this g...
nature.com
Chronic inflammation in IBD reshapes the stem cell niche—reducing LGR5⁺ stem cells while expanding OLFM4⁺ immune-responsive populations, revealing epithelial plasticity. @karapedsgastrodoc.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
Another promising finding for 5HT4R agonism! This study found that in participants with previous episodes of depression, 5-HT4R agonist, prucalopride, had pro-cognitive effects (learning, memory & attention). @karapedsgastrodoc.bsky.social doi.org/10.1016/j.ns...
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doi.org
A large cohort study of 126,735 adults followed over 14.5 years show the high prevalence of IBS cases in instances of severe emotional and physical neglect, as well as abuse. @karapedsgastrodoc.bsky.social www.nature.com/articles/s41...
Long-term risk of irritable bowel syndrome associated with adverse childhood and adulthood experiences: a large-scale prospective cohort study - Translational Psychiatry
Translational Psychiatry - Long-term risk of irritable bowel syndrome associated with adverse childhood and adulthood experiences: a large-scale prospective cohort study
nature.com
A gut-acting 5-HT4 drug, prucalopride, shows faster antidepressant/anxiolytic effects than fluoxetine in mice, with parallel shifts in the microbiome. @karapedsgastrodoc.bsky.social www.nature.com/articles/s41...
Prucalopride, a serotonin type 4 receptor agonist, induces fast anxiolytic/antidepressant effects and concomitant changes in the gut microbiota - npj Biofilms and Microbiomes
npj Biofilms and Microbiomes - Prucalopride, a serotonin type 4 receptor agonist, induces fast anxiolytic/antidepressant effects and concomitant changes in the gut microbiota
nature.com
Food is more than fuel for growing bodies, it may shape developing minds. Higher ultraprocessed food intake in preschool years was associated with more behavioral and emotional symptoms in early childhood. @karapedsgastrodoc.bsky.social jamanetwork.com/journals/jam...
Ultraprocessed Food Consumption and Behavioral Outcomes in Canadian Children
This cohort study examines the associations between intake of ultraprocessed foods at age 3 years and behavioral outcomes at age 5 years among children in Canada.
jamanetwork.com
Amazing new study shows how pain-sensing nerves work together with tuft cells of the intestinal epithelium to protect the gut from infection. @karapedsgastrodoc.bsky.social www.nature.com/articles/s41...
Neuro-epithelial circuits promote sensory convergence and intestinal immunity - Nature
Specific pain-sensing nociceptors and chemosensory tuft cells form a circuit to promote type 2 immune responses in the intestine.
nature.com
Balancing benefit and risk is key in IBS therapy. Quantifying the ‘number needed to harm’ helps clinicians better evaluate treatment safety. @karapedsgastrodoc.bsky.social pmc.ncbi.nlm.nih.gov/articles/PMC...
The Safety of Pharmacotherapy for Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis
Understanding the safety of pharmacotherapy for irritable bowel syndrome (IBS) enables individuals to make informed treatment decisions. While many studies include the number needed to treat to highlight therapeutic benefits, adding the number ...
pmc.ncbi.nlm.nih.gov
Gut health finally has a scientific definition. ISAPP’s new consensus defines it as normal GI function without disease or symptoms that affect quality of life. @karapedsgastrodoc.bsky.social www.nature.com/articles/s41...
The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of gut health - Nature Reviews Gastroenterology & Hepatology
This Consensus Statement provides a definition of the term ‘gut health’, as well as a discussion of the relevant domains that contribute to gut health and a framework for appropriate use of the term i...
nature.com
This cool new paper reports an important characterization of how enteroendocrine cells in the gut are positioned relative to sensory neurons. Not surprisingly, there are significant regional differences along the GI tract! @karapedsgastrodoc.bsky.social onlinelibrary.wiley.com/doi/10.1111/...
The Neuroepithelial Landscape of Enterochromaffin Cells Varies Across Gastrointestinal Location
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onlinelibrary.wiley.com
Interesting preprint showing that the behavioral effects of lithium are mediated by the gut-brain axis! www.biorxiv.org/content/10.6... @karapedsgastrodoc.bsky.social
biorxiv.org
This study maps distinct enteric neuron subtypes and shows how each shapes key intestinal functions, from fecal output to feeding. A big step forward in understanding gut–brain neural circuits. www.sciencedirect.com/science/arti... @karapedsgastrodoc.bsky.social
Properties and functions of transcriptionally distinct enteric neurons
The influence of the nervous system on the intestine is carried out by a combination of enteric, sensory, and autonomic innervation. However, disambig…
sciencedirect.com
Enteric Neurons Join the Dialogue on Pain! A recent study reveals that cholinergic circuits within the colon communicate through dorsal root ganglion (DRG) pathways, particularly following inflammation. 👉 www.cell.com/neuron/fullt...
An enteric-DRG pathway for interoception and visceral pain in mice
Wang et al. reveal a neuroanatomical and functional crosstalk between cholinergic enteric neurons and sensory neurons of the dorsal root ganglia that mediates colonic interoception. While this…
cell.com
🚨The NYU Pain Research Center (PRC) and Department of Molecular Pathobiology at NYU Dentistry are seeking Assistant or Associate Professors in the fields of chronic pain mechanisms, pain therapeutics, and related disciplines. More info and apply: apply.interfolio.com/176454
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📢New paper in Nature Mental Health! Dr. @karapedsgastrodoc.bsky.social is co-author on a review exploring how the gut microbiota shapes mental health through the gut–brain axis.🧠 🔗 doi.org/10.1038/s442...
Distinguishing the causative, correlative and bidirectional roles of the gut microbiota in mental health - Nature Mental Health
This Review provides a critical assessment of current mechanistic and clinical evidence on the interaction between the gut microbiota and mental health to differentiate causative, correlative and bidi...
doi.org
