Delighted to have contributed to this piece in Cell: Mapping Intratumor Heterogeneity Across Layers, part of the special issue celebrating the Hallmarks of Cancer. Thanks to @yardenasamuels.bsky.social for her leadership on this one. authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
Cancer cell plasticity is viewed as a driver of therapy resistance. Here, we propose the concept of “Field-Oriented” Therapy—leveraging plasticity rather than merely enduring it. To learn more, read: aacrjournals.org/cancerdiscov...
Simple cell geometry metrics reveal cancer cell diversity and plasticity and guide combination therapy
Intra-tumour heterogeneity (ITH) and cellular plasticity contribute to therapy resistance. Single-cell transcriptomics is the gold standard for assessing ITH, but this approach remains costly and slow...
researchsquare.com
🚀 New preprint! Meet ORIGAMI: Mapping cancer cell state heterogeneity and plasticity, predicting and steering therapy-induced trajectories to rationalize genotype-agnostic combination strategies with only two physical metrics (cell surface area and volume) www.researchsquare.com/article/rs-8...
Simple cell geometry metrics reveal cancer cell diversity and plasticity and guide combination therapy
Intra-tumour heterogeneity (ITH) and cellular plasticity contribute to therapy resistance. Single-cell transcriptomics is the gold standard for assessing ITH, but this approach remains costly and slow...
researchsquare.com
www.linkedin.com/posts/vib_hi...
#highlycitedresearchers #vib #teamscience #researchexcellence #impactthroughcuriosity #whysciencematters | VIB
PROUD I𝟏𝟗 𝐕𝐈𝐁 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡𝐞𝐫𝐬 𝐫𝐞𝐜𝐨𝐠𝐧𝐢𝐳𝐞𝐝 𝐚𝐬 𝐂𝐥𝐚𝐫𝐢𝐯𝐚𝐭𝐞 𝐇𝐢𝐠𝐡𝐥𝐲 𝐂𝐢𝐭𝐞𝐝 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡𝐞𝐫𝐬 𝟐𝟎𝟐𝟓 Yes, you read that right. And we are beyond proud. But what does this actually mean? Every year, Clarivate highlights ...
linkedin.com
Registration for Cancer Cell Plasticity closes on Monday 03 November! Join us online to explore the fundamental mechanisms that control cancer cell plasticity at multiple biological levels: eacr.org/conference/c...
Just like there are good and bad macrophages..., there are good and bad NK cells!! This has profound therapeutic implications, far beyond oncology! Thanks to CD for highlighting both papers and the superb and efficient editorial work! Thanks to our collaborators (especially Zihai Li) and funders!
Elizabeth McKenna@elizsmckenna.bsky.social · last yr.Now online in Cancer Discovery for the #EACR2025 presentation by @marinelab.bsky.social: Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype doi.org/10.1158/2159... @vib-ccb.bsky.social @pozniakjoanna.bsky.social
Unmissable for those working on melanoma and beyond.
Daniel Peeper Lab@peeperlab.bsky.social · last yr.The SMR 2025 Annual Congress (Amsterdam Oct 25-28) covers basic, preclinical & translational melanoma research of international top investigators. It is a very enjoyable conference with top faculty and now improved with ample opportunity for young investigators to network. Join us! smrcongress.org
Now online in Cancer Discovery for the #EACR2025 presentation by @marinelab.bsky.social: Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype doi.org/10.1158/2159... @vib-ccb.bsky.social @pozniakjoanna.bsky.social
rdcu.be/emi9N Fishing for Metastasis Initiating Cells (MICs): we summarize here a heroic effort from Christoph Klein and Melanie Werner-Klein labs, which describes a MIC population in lymph nodes and how these cells evade immune attack. #metastasis #melanoma #extracellularvesicles #cancerprevention
Fishing for melanoma metastasis-initiating cells in lymph nodes
Nature Cancer - The complex nature of metastasis-initiating cells (MICs) has long hindered our understanding of how cancer spreads and how to prevent it. A study now identifies a potential MIC...
rdcu.be
“Science has no passport, no gender, no ethnicity, no political party.” EC President Ursula von der Leyen, announcing a €500M initiative to attract top global talent. In a fractured world, science remains a unifying force – rooted in diversity, driven by curiosity, and shared by all humanity.
We are really looking forward to hosting YOU and these amazing speakers in Leuven. Whether you are a young trainee, an experienced postdoc or a leader in the field, please join us (you will not regret this!).
VIB Training & Conferences@vibtrainconf.bsky.social · last yr.The VIB Conference on Tumor Heterogeneity, Plasticity, & Therapy is back (3rd edition) on Dec 10-12 in Leuven! Join us at #THPT25 for 2 days of pioneering research & discussions on #tumorbiology and #cancertherapy resistance. Be part of the conversation: vibbio.tech/3DLsomq. @vib-ccb.bsky.social
An important step towards personalised (combination) cancer treatments. vib.be/en#/ We are very excited about this project! Thanks to Oliver Bechter and his team and Presage for their trust and vision.
Great talk from my friend and colleague @cedric-blanpain.bsky.social (Chemoresistance) at the @helloeacr.bsky.social conference on Drug Tolerant Persister Cells (Lyon, France). Thanks to the organizers for this exciting event.
Please join us for this exciting event!!! Very much looking forward to the great talks and discussions on this 🔥 topic
EACR - European Association for Cancer Research@helloeacr.bsky.social · last yr.Registration and abstract submission is now open for Cancer Cell Plasticity: Cracking the Code of Adaptation and Survival! Join us online on 02-03 December for a jam-packed programme discussing the latest discoveries in this field. eacr.org/conference/c...
Our latest piece "Decoding Melanoma’s Cellular Mosaic to Unlock Immunotherapy Potential" is available online: authors.elsevier.com/a/1khFK3QxxS... and will soon be published in @cp-trendscellbio.bsky.social. Thanks to @pozniakjoanna.bsky.social for taking the lead! Our Cover design proposal is below
Breaks are key to relaxed & unwind between sessions! This afternoon, @juliensage.bsky.social hit the courts with @marinelab.bsky.social & Lukas Dow - what better way to reset than a (maybe not so) friendly game of tennis🎾 #AMC25
Our excellent host, Julien Sage, sharing a surprising/unexpected role for T cells in the biology of small cell lung cancer …thanks Julien and Kevin for organising such a great @fusionconf.bsky.social (mouse models of cancer) conference!!
We took a deep dive into cancer progressions & metastasis this morning at #AMC25: 🧬Chris Marine on melanoma progression & therapy resistance 🐭 Eran Andrechek & Peter Westcott with cutting edge mouse models 🫁Katie Politi on progression & resistance in lung cancer 🌊Plus an exciting Catamaran tour⛵️
So happy to see this live, Slim! Congratulations to you, Ernesto and the whole team for your resilience, vision and creativity!
Slim Mzoughi@sleemmz.bsky.social · last yr.Thrilled to share my 1st brainchild, out today @naturegenet.bsky.social 🚀 Been hearing a lot about fetal-like states lately? We uncover the molecular mechanisms, functional significance and clinical relevance of #oncofetal reprogramming in CRC. www.nature.com/articles/s41... (rdcu.be/d9iSN) a 🧵
1) Huge thanks to @guccionelab.bsky.social @nickbarker @marinelab.bsky.social @ggargiul.bsky.social @owensansom 4 the fantastic collaboration. NIH funding #EarlyStageInvestigator. Towards #BetterTherapeuticStrategies 4 #CRC patients #Oncofetal #CRC #IntratumoralHeterogeneity #PhenotypicPlasticity
Congratulations Ginevra and the whole Fendt team! This is very exciting work!
Ginevra Doglioni@ginevradoglioni.bsky.social · 2y agoBeyond excited to share that the main work of my PhD on how aspartate signaling drives metastasis is finally out in @nature.com ✨ -> go.nature.com/4gCYtuL A huge thank to the @fendtlab.bsky.social and all our collaborators for the terrific team work 🙏 A brief 🧵
End-of-the-year preprint & first 🧵 where the sky is blue! Ever wondered how a cancer driven by a single mutant oncogene becomes molecularly & cellularly heterogeneous? Why metastases share drivers w/primary tumors but are more aggressive?
Looking for an enthusiastic bioinformatician (long-term postdoctoral follow or staff scientist) interested in cancer/melanoma biology and therapy resistance. Data Science (single-cell, spatial multiomics integration), Machine learning, R, Pyhthon... jobso.id/ik9e
Bioinformatician Postdoctoral Level - VIB
Position summary The Chris Marine lab at the VIB Center for Cancer Biology (https://ccb.sites.vib.be/en) is actively seeking a skilled bioinformatician proficient in analyzing and integrating single-...
jobso.id
www.cell.com/cell/fulltex... My first post on BSKY will be a citation from Sydner Brenner (2002): "So genocentric has modern biology become that we have forgotten that the real units of function and structure in an organism are cells and not genes" highlighted by S Quake in this interesting piece.
The cellular dogma
In this essay, I will put forth what I see as a major conceptual challenge for biology in the next decade, one that is inspired by Crick’s Central Dogma: understanding information flow in the cell in ...
cell.com
