🔬 Come build something new with us in NYC 🗽. We're hiring a Postdoctoral Fellow and an Assistant Scientist at Mount Sinai. We study functional heterogeneity, cell-state plasticity, and tumor evolution, and we're looking for curious, ambitious scientists ready to tackle bold questions. Please share!

I have two open positions (wet and dry lab) to work on phenotypic plasticity and therapy resistance. Come join a vibrant team in a vibrant city!

Are you passionate about phenotypic plasticity and therapy resistance? | Slim Mzoughi

Are you passionate about phenotypic plasticity and therapy resistance? Curious about the epigenetic mechanisms driving these processes? Excited to make transformative discoveries and take your career ...

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📢 Exciting news: The Mzoughi Lab will launch in January 2026 at the Icahn School of Medicine at Mount Sinai in NYC! Young talents and cell plasticity enthusiasts—stay tuned for upcoming opportunities!

🔈We've got the cover of the 2nd NG issue for 2025🙌 Read about the cover: In the comment👇 Also check out our research briefing🚨 (link below): nature.com/articles/s41... nature.com/articles/s41...

❗Don't miss the Research Briefing❗ ⬇️ www.nature.com/articles/s41...

Oncofetal reprogramming induces phenotypic heterogeneity in colorectal cancer - Nature Genetics

Phenotypic plasticity of cancer cells is increasingly recognized as a mechanism of tumor escape from targeted therapies. Yet, the phenotypic heterogeneity of colorectal cancer remains poorly explored....

nature.com

📢ONLINE @naturegenet.bsky.social 📰Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer. By @sleemmz.bsky.social, @guccionelab.bsky.social and colleagues. ⬇️ www.nature.com/articles/s41...

Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics

Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...

nature.com

Nice paper from @sleemmz.bsky.social et al underscoring the importance of stem cell transdetermination in CRC. RXR, YAP, and AP1 signalling collectively control access to revival stem cells and inhibition of these nodes limits plasticity to improve chemosensitivity. www.nature.com/articles/s41...

Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics

Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...

nature.com

So happy to see this live, Slim! Congratulations to you, Ernesto and the whole team for your resilience, vision and creativity!

Slim Mzoughi@sleemmz.bsky.social · last yr.

Thrilled to share my 1st brainchild, out today @naturegenet.bsky.social 🚀 Been hearing a lot about fetal-like states lately? We uncover the molecular mechanisms, functional significance and clinical relevance of #oncofetal reprogramming in CRC. www.nature.com/articles/s41... (rdcu.be/d9iSN) a 🧵

Out now @naturegenet.bsky.social: **Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer** www.nature.com/articles/s41... Interesting story about #oncofetal #reprogramming and phenotypic #plasticity in #colorectal #cancer. #science #epigenetics #OncoSky

Oncofetal reprogramming drives phenotypic plasticity in WNT-dependent colorectal cancer - Nature Genetics

Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in combination with chemot...

nature.com

bioRxivpreprint@biorxivpreprint.bsky.social · 3y ago

A Mutation-driven oncofetal regression fuels phenotypic plasticity in colorectal cancer https://www.biorxiv.org/content/10.1101/2023.12.10.570854v1

Thrilled to share my 1st brainchild, out today @naturegenet.bsky.social 🚀 Been hearing a lot about fetal-like states lately? We uncover the molecular mechanisms, functional significance and clinical relevance of #oncofetal reprogramming in CRC. www.nature.com/articles/s41... (rdcu.be/d9iSN) a 🧵

The Human Cell Atlas is yielding detailed maps of human tissues and systems throughout life, along with methods to handle single-cell data. Four scientists reflect in Nature on how the project is transforming our understanding of human biology. 🧪

Cellular atlases are unlocking the mysteries of the human body

Scientists reflect on insights from the Human Cell Atlas.

go.nature.com

A shared meal, a kiss on the cheek: these social acts bring people together — and bring their microbiomes together, too. …. It is fascinating how our microbiome is shaped! www.nature.com/articles/d41...

Your friends shape your microbiome — and so do their friends

Analysis of nearly 2,000 people living in remote villages in Honduras reveals who’s spreading gut microorganisms to whom.

nature.com

go.bsky.app/QW8Ghu5

Happy with the move to🦋 ! I hope we can use this platform as a fresh start to foster meaningful scientific discussions and collegiality, rather than superficial praise or unproductive disagreements.