Exciting new work from Barna Lab @stanfordmedicine.bsky.social www.science.org/doi/10.1126/...

A subcellular map of translational machinery composition and regulation at the single-molecule level

Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...

science.org

Tumor-reactive T cell receptors are rapidly identified from lymphocyte scRNA-seq data go.nature.com/49O5INm rdcu.be/d8L1u

Prediction of tumor-reactive T cell receptors from scRNA-seq data for personalized T cell therapy - Nature Biotechnology

Tumor-reactive T cell receptors are rapidly identified from lymphocyte scRNA-seq data.

go.nature.com

Our cross-journal call for paperss on targeted protein degradation is still open for submissions! We welcome submissions focusing on the design, development, and application of targeted protein degradation modalities. @commschem.bsky.social @naturecomms.bsky.social www.nature.com/collections/...

MicroRNAs From their role in cancer jci.org/articles/vie... to Rejuvenating aged mice, w/ enhanced physical and cognitive function, and longevity sciencedirect.com/science/arti... + explainer nature.com/articles/d41...

A study in Nature Immunology defines a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveals important insights into the mechanisms by which vaccines induce durable immunity. 🔒

System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans - Nature Immunology

Pulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccines induce durable immunity.

go.nature.com

What’s new in #Antihypertensive therapies? 📍Aldosterone synthase inhibitors 📍Angiotensinogen targeted therapies 📍GLP1/GIP receptor agonists 📍Natriuretic peptide 1 receptor agonists And more.. @circaha.bsky.social buff.ly/4h45ULk www.ahajournals.org/doi/epub/10....

Mechanism of #syncope: role of ambulatory BP monitoring & CV autonomic function assessment #CardioSky #MedSky #ESC @escardio.bsky.social @victoriadelgadomd.bsky.social @jgrapsa.bsky.social @mmamas1973.bsky.social @vassv.bsky.social @gimelliale.bsky.social academic.oup.com/eurheartj/ad...

🫀 #Lipoprotein(a) is much more atherogenic than #LDL, bringing a much higher #cardiovascular risk. However, the testing demand has been low. Being linked to the individual's #genotype and not having been a target for #treatment up to now. Read more: jamanetwork.com/journals/jam...

Zerlasiran—A Small-Interfering RNA Targeting Lipoprotein(a)

This phase 2 randomized clinical trial evaluates the optimal dose, dosing interval, and safety of zerlasiran, a small-interfering RNA targeting hepatic synthesis of apolipoprotein(a), to treat patient...

jamanetwork.com

A new ‘molecular lantern’ detects brain metastasis in mice by inserting a probe thinner than a hair into the brain "Vibrational fiber photometry: label-free and reporter-free minimally invasive Raman spectroscopy deep in the mouse brain" www.nature.com/articles/s41...

Vibrational fiber photometry: label-free and reporter-free minimally invasive Raman spectroscopy deep in the mouse brain - Nature Methods

Vibrational fiber photometry enables Raman spectroscopy in the mouse brain with low impact, owing to the use of tapered fibers.

nature.com

Humanity’s newest brain gains are most at risk from ageing The largest declines in grey matter in the brain - a sign of ageing - occurred in the frontal cortex which provides evolutionary and cognitive advantages over non-human primates. www.nature.com/articles/d41...

Humanity’s newest brain gains are most at risk from ageing

The large prefrontal cortex provides evolutionary and cognitive advantages over non-human primates — but there’s a cost.

nature.com

#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair

Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.

cell.com

💊 #Antibiotic stewardship in patients with #sepsis is one of the use cases for #procalcitonin ( #PCT) testing. This study compares the effect and safety of guiding antibiotic #therapy with two blood #biomarkers, PCT and C-reactive protein ( #CRP). Read more: jamanetwork.com/journals/jam...

Biomarker-Guided Antibiotic Duration for Patients With Suspected Sepsis

This clinical trial assessed whether treatment protocols for monitoring C-reactive protein or procalcitonin safely reduced the amount of time critically ill adults with suspected sepsis received antib...

jamanetwork.com

Sex differences in the efficacy of angiotensin receptor blockers on kidney and cardiovascular outcomes among individuals with type 2 diabetes & diabetic kidney disease: post hoc analyses of the RENAAL & IDNT trials #NephSky #CardioSky #KidneyDisease #diabetes 👇👇 link.springer.com/article/10.1...

Sex differences in the efficacy of angiotensin receptor blockers on kidney and cardiovascular outcomes among individuals with type 2 diabetes and diabetic kidney disease: post hoc analyses of the RENA...

Aims/hypothesis Our aim was to assess sex differences in the efficacy of angiotensin receptor blockers (i.e. losartan and irbesartan) on kidney and cardiovascular outcomes in individuals with type 2 d...

link.springer.com

The IL-2 SYNTHORIN molecule promotes functionally adapted Tregs in a preclinical model of type 1 diabetes insight.jci.org/articles/vie...

🎆4 years in the making! Thrilled to share the 1st spatial single cell aging clock ⏰ www.nature.com/articles/s41... We use #AI + spatial transcriptomics to discover what makes some cells age faster/slower in the brain 🧠 Led by Eric Sun and awesome collaboration w/ @brunetlab.bsky.social🧵

Hi Bluesky community! 👋 Are you looking forward to 2025 as much as we are? 👀 We just updated our 2025 Annual Poster to include even more events for you to join, so go and have a look! ➡️ s.embl.org/poster-bl #EMBLEvents #molecularbiology #lifesciencetraining

T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics. #Immunity "An in vitro TCR engineering platform for the creation, modification, and comprehensive profiling of TCRs that can target self-antigens." Open Access www.cell.com/immunity/ful...

T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics

Abdelfattah et al. developed an engineering platform (T-Switch) for the creation, modification, and high-throughput profiling of T cell receptors (TCRs) to desired targets, particularly self-antigens. T-Switch identified potent and specific candidate TCRs against a clinically relevant cancer self-target highly expressed in neuroblastoma and has potential for broader application in immunotherapy.

cell.com

🫀Point-of-care ( #POC) high sensitivity #troponin I ( #hsTnI) testing boosts Acute #Coronary Syndrome detection! This study proves its efficiency, supporting faster decisions in #emergency care. Read more: pubmed.ncbi.nlm.nih.gov/39239902/

Evaluation of the analytical and clinical performance of a high-sensitivity troponin I point-of-care assay in the Mersey Acute Coronary Syndrome Rule Out Study (MACROS-2) - PubMed

The whole blood POC TriageTrue hs-TnI assay demonstrates imprecision levels consistent with high sensitivity characteristics and has a clinical performance equivalent to an established, validated and ...

pubmed.ncbi.nlm.nih.gov

With more layers of data, our ability to predict a person's risk of heart disease is getting better and better acpjournals.org/doi/10.7326/... [adding in social determinants of health, lifestyle, genomics, and other data] @annalsofim.bsky.social

🫀This article shows the importance of monitoring #NTproBNP and high sensitivity #troponin I ( #hsTnI) in obstructive hypertrophic cardiomyopathy. The concentrations of both #biomarkers are crucial to monitor the clinical response to therapy. European Heart Journal academic.oup.com/eurheartj/ar...

Cardiac biomarkers and effects of aficamten in obstructive hypertrophic cardiomyopathy: the SEQUOIA-HCM trial

AbstractBackground and Aims. The role of biomarker testing in the management of obstructive hypertrophic cardiomyopathy is not well defined. This pre-speci

academic.oup.com

Resistance to one antibiotic can make bacteria resistant or sensitive to another antibiotic, opening paths for combinatorial treatments. A study in Nature Microbiology presents an approach to systematically discover and understand such antibiotic relationships. https://go.nature.com/49of3Mk 🧪

🧪Importance of vitamin D and its deficiency "By highlighting the biochemical pathways through which vitamin D influences calcium absorption and bone mineralization, these studies underscore its importance in maintaining strong and healthy bones." Open access pdf.ipinnovative.com/pdf/23133

‼️Tracking — and Tackling — the Recent Resurgence of Syphilis “…there was a nearly 80% increase in syphilis cases during the five years spanning 2018-2022.” www.healthcarebusinesstoday.com/resurgence-s...

Tracking—and Tackling—the Recent Resurgence Of Syphilis - Healthcare Business Today

Explore the recent resurgence of syphilis, its causes, and effective strategies for tackling this public health challenge. Stay informed and proactive about prevention and treatment.

healthcarebusinesstoday.com

Strong new evidence for T cell exhaustion in myalgic encephalomyelitis (ME/CFS) reflecting chronic viral infection, relevant to #LongCovid, and possible path to treatment candidates www.pnas.org/doi/epub/10.... @pnas.org

🩸Ensuring Transfusion Safety: Detecting Irregular Antibodies to Prevent Alloimmunization “Precision alloantibody identification complements phenotype and genotype matching to advance transfusion safety.” ashpublications.org/blood/articl...