I wonder if my family will stop thinking I’m daft as a brush now I am Prof of Cardiorespiratory Medicine in Cambridge? Scratch that. I already know the answer.

www.jci.org/articles/vie.... Our attempt to take in end-organ dysfunction with the liver as our focus in PAH/RV Failure. @jci.org @natrevgastrohep.nature.com @the-asci.org @mark-toshner.bsky.social

Paper drop where we question the mechanism of action of sotatercept. Think this will only get more important as the drug does lots of interesting things. pubmed.ncbi.nlm.nih.gov/42160453/

Sotatercept reduces bone morphogenetic protein signaling in patients with pulmonary arterial hypertension - PubMed

Pulmonary arterial hypertension (PAH) is a rare, life-limiting disease where imbalances in the transforming growth factor-β (TGF-β) and bone morphogenetic protein receptor type II (BMPR-II) superfamil...

pubmed.ncbi.nlm.nih.gov

You will not find a clearer thinker and good human being to boot. Medical leadership is painfully difficult and unfortunately full of mediocrity at an important time for the profession. Vote for someone better! bsky.app/profile/drlk...

Dr Louella Vaughan@drlkvaughan.bsky.social · 5mo ago

Voting opens today for @rcphysicians.bsky.social elections. I am standing for Vice President for Education and Training. It's the first elections where Members will also be able to vote. Please encourage all eligible to exercise their franchise. More about me here: tinyurl.com/22j7nypk

An excellent candidate IMO, careful, thoughtful, and passionate about training enough high quality doctors.

Dr Louella Vaughan@drlkvaughan.bsky.social · 6mo ago

I am running for Vice President for Education and Training. tinyurl.com/22j7nypk

Voting opens today for @rcphysicians.bsky.social elections. I am standing for Vice President for Education and Training. It's the first elections where Members will also be able to vote. Please encourage all eligible to exercise their franchise. More about me here: tinyurl.com/22j7nypk

The Blue Journal thanks Eckart De Bie, MD, MPhil, for his contribution to the January issue Inflammation and Obesity Correlate in Pulmonary Hypertension but Associate with Diverging Outcomes @mark-toshner.bsky.social academic.oup.com/ajrccm/artic...

Every once in a while awards committees get it right! If there is a more deserving person out there of this than Marc Humbert, I don’t know them! eur03.safelinks.protection.outlook.com?url=https%3A...

Marc Humbert : Pulmonary Arterial Hypertension, The Battle of a Committed Doctor · Inserm

Inserm Grand Prize winner, lung specialist and researcher Marc Humbert has devoted his career to deciphering the mechanisms of pulmonary arterial hypertension. From disease characterization to the cre...

eur03.safelinks.protection.outlook.com

The @washingtonpost.com story on Tylenol & autism leaves out a MAJOR 2.5M sibling-controlled study of children in Denmark, which "found no evidence that acetaminophen use during pregnancy was associated with children’s risk of autism, ADHD or intellectual disability." jamanetwork.com/journals/jam...

Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability

This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.

jamanetwork.com

After our mammoth international patient engagement work- some actions for the global community to consider pubmed.ncbi.nlm.nih.gov/40662200/

Pulmonary Hypertension Global Patient Survey: A Call to Action 2025 - PubMed

Pulmonary Hypertension Global Patient Survey: A Call to Action 2025

pubmed.ncbi.nlm.nih.gov

The United States has recorded its highest annual measles cases in 33 years. The milestone marks a public health reversal in defeating a highly contagious, vaccine-preventable disease as the anti-vaccine movement gains strength.

U.S. measles cases reach 33-year record high as outbreaks spread

Johns Hopkins University data reflects the public health reversal in defeating the vaccine-preventable disease since measles was officially eliminated from the U.S. in 2000.

washingtonpost.com

First ever international survey of patients with pulmonary hypertension. Wonderful collaborative work. Lots of important and useful insights. t.co/XTvpbS4g8Y

@mark-toshner.bsky.social

My excellent student winning the best type of award. One for actually remembering the patient in amongst our research! bsky.app/profile/camb...

NIHR Cambridge Biomedical Research Centre@cambridgebrc.bsky.social · last yr.

AND FINAL CONGRATULATIONS to @cam.ac.uk MPhil student Vidisha Handoo, whose poster was voted the best of those on display at last week's Cambridge #PPI Showcase day @angliaruskin.bsky.social @cuh.nhs.uk Thanks to ALL our presenters & poster submissions, you were all great! 3/3

AND FINAL CONGRATULATIONS to @cam.ac.uk MPhil student Vidisha Handoo, whose poster was voted the best of those on display at last week's Cambridge #PPI Showcase day @angliaruskin.bsky.social @cuh.nhs.uk Thanks to ALL our presenters & poster submissions, you were all great! 3/3

Glasgow. Where the people are funniest because the weather is no joke. Good to be home!

I’m in the Guardian today, arguing that we should stop them all-class mental health lessons in schools I've thought very carefully about ‘going public’ with this, because it's a sensitive argument to make, especially in the face of so many young people struggling. (cont 🧵) tinyurl.com/vun92cz7

Mental-health lessons in schools sound like a great idea. The trouble is, they don’t work | Lucy Foulkes

All-class therapy sessions don’t help, and may even make matters worse. The evidence shows we need different solutions, says Dr Lucy Foulkes, an academic psychologist at Oxford University

theguardian.com

www.ahajournals.org/doi/10.1161/.... Our most recent work attacking RV failure! @mark-toshner.bsky.social @ahascience.bsky.social @ahajournals.bsky.social

Lactobacillus Restructures the Micro/Mycobiome to Combat Inflammation-Mediated Right Ventricular Dysfunction in Pulmonary Arterial Hypertension | Circulation: Heart Failure

BACKGROUND: Inflammation suppresses right ventricular (RV) function in pulmonary arterial hypertension (PAH). In particular, we showed GP130 (glycoprotein-130) signaling promotes pathological microtub...

ahajournals.org

That joyous moment when you get rid of the 🐵 on your back, AKA submitting that 27 page rebuttal after 9 months of revisions… 🎉 images.squarespace-cdn.com/content/v1/5...

⭐️Meet the speaker⭐️ We’re delighted to have @mark-toshner.bsky.social joining #DDDS2025, who will be speaking on 'How to define or prove disease modification'.

I think most senior doctors in UK in positions of importance/power have just turned away rather than consider how terribly demoralised the trainees are by the current awful system.

Quite a stunning result this. Sotatercept in severe pulmonary arterial hypertension www.nejm.org/doi/full/10....

Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death | NEJM

Sotatercept improves exercise capacity and delays the time to clinical worsening in patients with World Health Organization (WHO) functional class II or III pulmonary arterial hypertension. The eff...

nejm.org

‘My dad is so cringe’. I’ve reached peak parenting

🎥 Highlights from yesterday's VPD-HLRI Monthly Seminar! Great talks by Prof. Jason Gill from @uofglasgow.bsky.social and our very own Prof. Murray Clarke. Thanks to our speakers and attendees! #HLRI #MetabolicHealth #VascularInflammation @cambridgeuni.bsky.social @murrayclarkelab.bsky.social

Just gave a talk with the absolute brightest lights I’ve ever had blinding me from back of auditorium. Really affected my game!

The view from Adelaide convention centre is a bit special eh?!

Very excited to share our work in Imatinib in PAH. Read on for the TLDR t.co/q7Uyg8uRdJ

Very excited to share our work in Imatinib in PAH. Read on for the TLDR t.co/q7Uyg8uRdJ

Longer term post-hospital morbidity and mortality following admission with Covid-19: A systematic review and meta-analysis. publications.ersnet.org/content/erjo... @charlottesummers.bsky.social @mark-toshner.bsky.social @lukeflower.bsky.social

“Johns Hopkins has bet very heavily on a century & a quarter of partnership with the federal government,” said Dr. Theodore Iwashyna, a critical-care physician… “If the federal government decides it doesn’t want to know things anymore, that would be bad for Johns Hopkins & devastating for Maryland.”

Johns Hopkins Plans Staff Layoffs After $800 Million Grant Cuts

Local and international health research efforts are already winding down as the university braces for even more potential cuts.

wsj.com