Martijn Selten
@martijnselten.bsky.social
Neuroscientist | Research Associate @ King's College London | Exploring inhibitory interneuron plasticity & neural circuit dynamics in health & disease 📍London, UK | 🔬Marinlab
I'm honoured to have received the 2026 Top Paper Award at #DNM26 for our paper on the homeostatic regulation of PV interneurons. Many thanks to all my co-authors from the @marinlab.bsky.social at the @devneuro.bsky.social! If interested, you can read the paper here: www.nature.com/articles/s41...
I'm excited to present at #DNM26 on Friday morning! With Monika Moissidis, Moritz Negwer, Ronald van Kesteren, and @laureverret.bsky.social, we'll explore how PV interneurons shape brain function across development, plasticity, and aging. Join us for Session 21!
Ever wondered how GABAergic interneurons shape cognition? The IN-CODE consortium's latest NeuroView article introduces a "population approach", shifting the focus from individual interneurons to cooperative networks. Dive into the future of interneuron research here: doi.org/10.1016/j.ne...
Monika is such an amazing scientist. It has been such a privilege to see this story grow and develop during my time at @marinlab.bsky.social. I am so happy to see this finally out. Well done to all authors. @martijnselten.bsky.social @clembrnrd.bsky.social
Oscar Marín Lab@marinlab.bsky.social · last yr.1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social @wellcometrust.bsky.social
New research has established the molecular mechanism that drives interneurons in the cerebral cortex to mature. The work provides clarity how cortical circuits develop and on the mechanisms behind neurodevelopmental disorders. Click to learn more👇 bit.ly/3THw7Gb
"Molecular switch” in the brain may explain why toddlers are uncoordinated
New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has established the molecular mechanism that drives interneurons in the cerebral cortex to mat...
bit.ly
1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social @wellcometrust.bsky.social
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...
cell.com
🚨 New Paper Alert! 🚨 I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner. Link below 👇 www.cell.com/cell/fulltex... @cellpress.bsky.social @marinlab.bsky.social
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...
cell.com
📣New study in Neuron, featuring modeling insights: "Cell-Specific Dendritic Integration in Cortical GABAergic Interneurons"! It reveals PV & SST interneurons compute differently. This highlights how distinct dendrites enable specialized brain computations! www.sciencedirect.com/science/arti...
Distinct dendritic integration strategies control dynamics of inhibition in the neocortex
Dendrites critically influence single-neuron computations, but their role in neocortical GABAergic interneurons (INs) remains poorly understood. We fo…
sciencedirect.com
Dr. Katie Long is leading vital research, funded by an MRF award, to learn how pregnant people feel about vaccines during pregnancy. We want your views! Take this short survey: tinyurl.com/vaccines-in-... For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy
Fos labels a distinct excitatory neuron ensemble for memory retrieval https://www.biorxiv.org/content/10.1101/2025.06.14.659414v1
@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...
Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation
Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…
sciencedirect.com
Very happy that this work is finally out in @pnas.org! We show that synaptic and intrinsic forms of homeostatic plasticity sense distinct aspects of network activity, and can thus be independently recruited by distinct network functions. A thread: www.pnas.org/doi/10.1073/...
Modular arrangement of synaptic and intrinsic homeostatic plasticity within visual cortical circuits | PNAS
Neocortical circuits use synaptic and intrinsic forms of homeostatic plasticity to stabilize key features of network activity, but whether these di...
pnas.org
1/6 Why does the brain maintain such precise excitatory-inhibitory balance? Our new preprint explores a provocative idea: Small, targeted deviations from this balance may serve a purpose: to encode local error signals for learning. www.biorxiv.org/content/10.1... led by @jrbch.bsky.social
New paper from Julie Jézéquel and the Rico lab on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f
Cadherins orchestrate specific patterns of perisomatic inhibition onto distinct pyramidal cell populations
Nature Communications - How cortical interneurons establish precise connections among intermingled populations of excitatory neurons remains unclear. Here, the authors reveal that Cadherins...
rdcu.be
Today I started recording these fantastic pyramidal neurons in layer 2/3 of the somatosensory cortex! New collab with @igenescu.bsky.social.
Nature research paper: Regulation of PV interneuron plasticity by neuropeptide-encoding genes. https://go.nature.com/4lWkesG
Regulation of PV interneuron plasticity by neuropeptide-encoding genes - Nature
Increasing the activity of individual parvalbumin-expressing interneurons in the mouse brain modulates the number and strength of inhibitory parvalbumin synapses received by these cells through changes in the expression of the neuropeptide-encoding genes Vgf and Scg2.
go.nature.com
🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including @clembrnrd.bsky.social and @marinlab.bsky.social. Read the paper at www.nature.com/articles/s41....
Regulation of PV interneuron plasticity by neuropeptide-encoding genes - Nature
Increasing the activity of individual parvalbumin-expressing interneurons in the mouse brain modulates the number and strength of inhibitory parvalbumin synapses received by these cells through c...
nature.com
Oscar Marín Lab@marinlab.bsky.social · last yr.1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu
I will soon start recruiting for a Wellcome-funded postdoc position! I’ll be at the #BNA2025 meeting next week. If you like cortical development, wiring, and post-transcriptional regulation, do get in touch and we can have a chat in Liverpool! 😀
Job alert 🚨 We are hiring a research assistant! This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34. Please spread the word!
Paper accepted!!! Stay tuned for updates very soon! (Now time for a little celebration)
Our little update on the latest knowledge on interneuron wiring! www.sciencedirect.com/science/arti...
Dynamic regulation of cortical interneuron wiring
Inhibitory interneurons play crucial roles in modulating the circuits and activity patterns of the cerebral cortex. In particular, interneurons must a…
sciencedirect.com
Excited to share the latest work from our lab where we examined the role of pyramidal cells in regulating microglia development! As per tradition here is a graphical summary of our paper in comic form. www.science.org/doi/10.1126/...
