1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social @wellcometrust.bsky.social

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons

Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

cell.com

🚨 New Paper Alert! 🚨 I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner. Link below 👇 www.cell.com/cell/fulltex... @cellpress.bsky.social @marinlab.bsky.social

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons

Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

cell.com

We're #hiring for a new role as Senior #ExecutiveAssistant to our fantastic Director and Managing Director! Deadline 23 June @marinlab.bsky.social www.kcl.ac.uk/jobs/116505-...

Senior Executive Assistant

kcl.ac.uk

How to find Evolutionary Conserved Enhancers in 2025? 🐣-🐭 Check out our paper - fresh off the press!!! We find widespread functional conservation of enhancers in absence of sequence homology Including: a bioinformatic tool to map sequence-diverged enhancers! rdcu.be/enVDN github.com/tobiaszehnde...

Conservation of regulatory elements with highly diverged sequences across large evolutionary distances

Nature Genetics - Combining functional genomic data from mouse and chicken with a synteny-based strategy identifies positionally conserved cis-regulatory elements in the absence of direct sequence...

rdcu.be

Still openings, check it out!

Denis Jabaudon@djabaudon.bsky.social · 2y ago

🧠Job Opening!🧠 We are opening 2️⃣! positions – bioinformatics / molecular biology – in a project studying how temporal patterns set up connectivity in human brain tissue. @institutimagine.bsky.social. Full details below, contact me for details if interested. And please retweet (re-bluesky?)!

On the value of investing in curiosity driven research - which in this case contributed to the personalised gene therapy for a rare disease on.ft.com/45rXI50 @anjahuja.bsky.social

🎙️[49] ENTENDER EL CEREBRO PARA REGULARLO 👨‍🔬 con #OscarMarínParra @MarinLab Alteraciones durante el desarrollo de nuestro🧠 pueden ser la causa de desordenes psiquiátricos como #autismo, #epilepsia, #bipolaridad o #esquizofrenia #Neurociencias (1/3)

Great @nature.com paper on the early stages of human cortical development, led by @qianxuyu.bsky.social from C. Walsh’s lab, in collaboration with @drmingyaoli.bsky.social A wonderful new resource to probe area & layer specification 🧪🧠🧬

Spatial transcriptomics reveals human cortical layer and area specification - Nature

Multiplexed error-robust fluorescence in situ hybridization (MERFISH) together with deep-learning-based nucleus segmentation enabled the construction of a highly detailed and informative spatially res...

nature.com

Xuyu Qian@qianxuyu.bsky.social · last yr.

Today in @nature.com , we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas. We built an interactive browser to explore the spatial data: walshlab.org/research/cor... Paper link below 👇

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

A human-specific enhancer fine-tunes radial glia potency and corticogenesis - Nature

HARE5, a human accelerated region enhancer, modulates cortical development by influencing neural progenitor cell behaviour, leading to an enlarged neocortex with increased functional independence betw...

nature.com

1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu

Meet the 2025 @dev-journal.bsky.social Pathway to Independence (PI) fellows Eight developmental and stem cell biologists transitioning from postdoc to principal investigator journals.biologists.com/dev/pages/pi...

1/10 Our latest research, led by @martijnselten.bsky.social, identifies a mechanism through which Parvalbumin (PV) interneurons regulate their activity in the #cortex. This is the story @nature.com www.nature.com/articles/s41... ⬇︎ 🧵 @devneuro.bsky.social @kingsioppn.bsky.social @erc.europa.eu

Our new paper is out. We point out that large brained (and often smart) mammals and birds have evolved very different distribution of neurons numbers in the brain. This means that similar cognitive abilities have evolved in very different brains. www.sciencedirect.com/science/arti...

Paper accepted!!! Stay tuned for updates very soon! (Now time for a little celebration)