Single molecule studies from Arda Mizrak in the Farese/Walther @msk & Harper Labs @harvardcellbio.bsky.social shows how lipid droplet proteins track through ER networks to ultimately partition into nanodomains on droplets, dependent upon Trp-containing hairpin motifs www.nature.com/articles/s41...

Membrane bridges and nanodomain partitioning govern membrane protein targeting to lipid droplets - Nature Cell Biology

Mizrak et al. use single-molecule tracking to dissect mechanisms of protein targeting to lipid droplets. They show that nanodomain-based confinement drives selective protein accumulation on lipid drop...

nature.com

Don’t miss @jourdainlab.bsky.social present his talk “Harnessing nutrients and auxotrophies to study mitochondria” at Cell Press Symposia #CSMito2026 Early bird registration ends Friday! http://dlvr.it/TRw8wJ

“The barriers women face are not about ability — they never were” 🧪 #Academia in Sweden is still male-dominated at senior levels, but this can be changed if organizations take this seriously, says equality expert Lauri Robbins-Ericson ↓ www.scilifelab.se/news/lauri-r... #IWD2026 #WomenInSTEM

scilifelab.se

One more thing- here, together with amazing human being, friend & stellar physician scientist Abby Xie, we identify a new function of the TCA cycle, which is citrate clearance, now online at @cellpress.bsky.social: www.cell.com/cell/fulltex...

Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle

Beyond its traditional role in supporting bioenergetic and biosynthetic demands, the canonical TCA cycle is also essential for nutrient clearance. When pyruvate oxidation and citrate production increa...

cell.com

A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/

Aspartate availability drives differential engagement of the malate-aspartate shuttle

Brunner et al. report that malate-aspartate shuttle engagement is cell-state dependent and can be modulated by the availability of the amino acid aspartate. In differentiated cells, malate-aspartate s...

cell.com

Excited to share our speakers for the 4th Metabolism in Health & Disease conference! It's a fantastic line up already, but we welcome new ideas & applications too💡⚡ If you have a story to tell or a new perspective to learn from, we want to hear from you - submit by 13 April 2026 ➡️ bit.ly/45CT3MY

‼️🚨Hi all! The next Bioc Soc Membrane Contact Site Meeting will be in Chepstow, UK 28-30th Sept 2026. Fantastic speakers with talk slots still available. Sign up & abstract submission now open - limited spaces so register early! Hope to see you all there. Please share + RT 🙏

📆Save the Date📆 Our Metabolism in Health & Disease conference returns from 10-13 Oct 2026 - this time in Portugal! Keep informed about speaker announcements, grant & abstract opportunities by signing up for updates here: bit.ly/MHD26-SaveTh... @petemullen.bsky.social @annakrook.bsky.social

🚀 Excited to share new work from Daniel Haas. In collaboration with Jan Hasenauer and Daniel Weindl within @batenergy.bsky.social we've developed a software tool to map protein and lipid localization in cells, making spatial biology more accessible www.nature.com/articles/s41...

C-COMPASS: a user-friendly neural network tool profiles cell compartments at protein and lipid levels - Nature Methods

C-COMPASS is an open-source software designed to predict the spatial cellular distribution of proteins and lipids from cellular organelle profiling using a neural network-based regression model.

nature.com

🔗To the original publication: www.nature.com/articles/s41... @nataliekrahmer.bsky.social @diabresearch-dzd.bsky.social @unibonn.bsky.social

C-Compass – Ai-Based Software Maps Proteins and Lipids Within Cells Developed by #HelmholtzMunich, DZD & University of Bonn, C-COMPASS makes spatial proteomics & lipidomics easier to use – no coding needed. 👉 t1p.de/2gn5c

Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination. www.cell.com/cancer-cell/...

Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression

Schweizer et al. profile the tumor progression from non-invasive serous borderline tumors of the ovary to metastatic low-grade serous ovarian cancer. By integrating cell-type resolved Deep Visual Prot...

cell.com

Thrilled to share that our manuscript mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell. @annakrook.bsky.social @juleenrzierath.bsky.social @cbmr.science doi.org/10.1016/j.ce...

There a lot of use of NAD+ supplements out there, without evidence of anti-aging effects in people. Here's some new data that detracts from NAD's role in modulating the aging process www.cell.com/cell-metabol...

NAD depletion in skeletal muscle does not compromise muscle function or accelerate aging

NAD depletion in skeletal muscle does not impair tissue integrity and function or accelerate aging, as shown in a mouse model with an 85% decrease in muscle NAD+ levels. Muscle structure, metabolism, ...

cell.com

On becoming an autocracy @newyorker.com www.newyorker.com/magazine/202...

My story about @kevinh-phd.bsky.social, nutrition and metabolism scientist at N.I.H., who felt compelled to take early retirement after experiencing censorship of his work under the new administration. www.nytimes.com/2025/04/16/w...

Leading Nutrition Scientist Departs N.I.H., Citing Censorship (Gift Article)

Kevin Hall said his work on ultraprocessed foods has been “hobbled” under the Trump administration. Scientists have been raising such concerns for months.

nytimes.com

After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology.

Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution. Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time. www.nature.com/articles/s41...

Deep Visual Proteomics maps proteotoxicity in a genetic liver disease - Nature

High-resolution spatial proteomics were used to map molecular events during hepatocyte stress in pseudotime across all fibrosis stages, recapitulating known disease progression markers and revealing e...

nature.com

I am a professor at Columbia University. All of the student NIH training grants have been canceled and now there are reports that ALL funding will be frozen. Why are Universities not banding together and speaking out publicly and forcibly about governmental attacks on biomedical research?

😢 this is not normal. And we should not turn away from this illegal BS!

Rejji Kuruvilla@rkuruvi1.bsky.social · last yr.

This, about a dedicated young researcher who found joy in her science, gutted me. “She does not even complain much about life in detention. If she had access to a laptop, and could analyze data from her laboratory at Harvard, “it would be good enough,” she said.” www.nytimes.com/2025/04/11/s...

“It is up to all of us to fix this. It’s not going to be because somebody comes and saves you.” - President Obama yesterday We must organize the pro-democracy majority to reclaim its power. Join an event near you for tomorrow’s nationwide day of action: handsoff2025.com?SQF_SOURCE=i...

Eine freie Wissenschaft gehört zum Kern liberaler, demokratischer Gesellschaften. Es ist in höchstem Maße besorgniserregend, dass die Freiheit der Wissenschaft in verschiedenen Regionen der Welt zunehmend unter Druck gerät.

With everything happening in the US right now, how safe are scientific conferences for foreign participants in the US? I think this is something we have to discuss as a scientific community. I am hesitating to register for US meetings due to the unpredictable situation. Others who feel the same?

Beautiful, powerful letter I have been asked by Harvard colleagues if they should keep quiet so as not put the larger Harvard community at risk with their words Took me a while to ruminate My response: Harvard is its people and their voices If we are silent then there is no Harvard to save

Ansley Erickson@ansleyerickson.bsky.social · last yr.

Agreed. We are speaking up where we can. docs.google.com/document/d/1...

While, in a nice collaboration with the Carvalho lab and @joanavferreira.bsky.social, PhD student Yara Ahmed used MD simulations to characterize the binding mechanism of the Dysferlin domain of Pex30 to phosphatidic acid. Anyone interested in a novel PA-sensor? (2/2) www.biorxiv.org/content/10.1...

Pex30-dependent membrane contacts sites maintain ER lipid homeostasis

In eukaryotic cells, communication between organelles and the coordination of their activities depend on membrane contact sites (MCS). How MCS are regulated under the dynamic cellular environment rema...

biorxiv.org

It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:

Time to fight !

Trump 2.0: an assault on science anywhere is an assault on science everywhere

US President Donald Trump is taking a wrecking ball to science and to international institutions. The global research community must take a stand against these attacks.

nature.com

@moiradonegan.bsky.social: „Now, the Democrats seem less like a resistance than an acquiescence. They are not mounting any meaningful opposition to Trump’s aggressive, sadistic mission. Instead they’re rolling over, like a submissive dog showing its belly, …“ www.theguardian.com/commentisfre...

Why are the Democrats so spineless? | Moira Donegan

No wonder the American public thinks of Democrats as out of touch, opportunistic and cowardly. That is because they are

theguardian.com

One week left to register! Registration possible until the 28th of February. Do not miss this chance! 🔥

TRR333 BATEnergy@batenergy.bsky.social · 2y ago

We would like to welcome you to our second International Conference on Brown and Beige Fat March 31st - April 02nd 2025 Top-class speakers, cutting edge research and respected experts will come together in beautiful Bonn. Registration is open! www.trr333.uni-bonn.de/batenergy-sy...