Had the pleasure of joining ACAMH @acamh.bsky.social to discuss my research on how reinforcement learning changes across adolescence — and how it is altered by risk factors for psychopathology

ACAMH - Association for Child and Adolescent Mental Health@acamh.bsky.social · 2w ago

What is #Anhedonia? What drives changes in reward responsiveness during adolescence? In this #MindtheKids podcast, we explore how adolescents learn from rewards and what this means for #depression risk and #mentalhealth outcomes with Holly Sullivan-Toole. https://bit.ly/4hcqSLk

A special highlight of our work on precision fMRI of the prefrontal cortex

WCIA 3 News@wcia3news.bsky.social · 2w ago

Out of the 30 million MRIs performed in the United States every year, data shows about 22% of those are on the brain. Now, researchers at the University of Illinois are mapping out ways to see the results at a more detailed level.

Happy Monday; TODAY'S THE DAY!! New ✨Sensitive Periods✨ content out NOW!! 🎤🎧🧠 This next edition of Sensitive Periods is a two-part miniseries featuring Dr. BJ Casey and Dr. Eveline Crone, and it discusses our current understanding of the adolescent brain.

What matters most for childhood brain organization? We analyzed 649 variables. The answer: Socioeconomics (SES); with brain patterns pointing at sleep & stress as drivers. Even brain-IQ associations were better explained by SES. In Science today: www.science.org/doi/10.1126/...

In sum, SES dominates childhood brain organization. Zip code matters most. These findings have been at the forefront of my mind daily, with Darwin’s quote living rent free in my head: “if the misery of the poor not be caused by the laws of nature, but by our institutions, great be our sin.”

🚨 New paper alert! 🎉🎉🎉 The largest meta-analysis to date on physical activity & mood in daily life is out in Nature Human Behaviour. An amazing effort led by Johanna Rehder & Markus Reichert et al. (2026)!

Nature Human Behaviour@nathumbehav.nature.com · 3mo ago

An individual participant data meta-analysis of how physical activity relates to affective well-being in daily life

Now out in JAD! We (@olinotom.bsky.social, and a co-author group largely stemming from Pitt) looked at how functional connectivity during positive mood predicts anxiety treatment response in an early adolescent sample. authors.elsevier.com/a/1n1KUbXYj0...

The past 15 months have marked a dark chapter in US science; one that will require significant effort to repair. But I'm not interested in duct tape and bandaid solutions. Our system had problems before Jan 20th, 2025. So, @standupforscience.net is doing what we do best: TAKING ACTION. 1/7

To enable broad adoption, we provide an open-source, lightweight, publicly available processing tool for deriving ∆R2* from standard fMRI datasets, enabling scalable investigation into basal ganglia neurophysiology and its contribution to neuropsychiatric risk across the lifespan.

🚨Preprint Alert🚨 Our new preprint 'A Scalable fMRI Estimate of Basal Ganglia Brain Tissue Iron for Use in Developmental and Translational Neuroscience' is live!! lnkd.in/gpG9naba

📣 📣 I am beyond excited to announce I will be joining the Yale Dept. of Psychology as an Assistant Professor in July 2027! Deepest gratitude to my colleagues and mentors, without whom this would not have been possible. More to come—I'll be recruiting students and hiring staff this coming year!

Precision reward/affect fMRI study out now in HBM! onlinelibrary.wiley.com/doi/10.1002/... @dvsmith.bsky.social @olinotom.bsky.social @coopersharp.bsky.social and @shenghanwang.bsky.social Intensively sampled task + rest fMRI data with behavioral manipulation openly available on OpenNeuro! (1/2)

Precision Imaging for Intraindividual Investigation of the Reward Response

We present open data for an intensively sampled precision imaging study including multiple reward-related tasks and a behavioral mood manipulation. Our initial analysis found low test–retest reliabil....

onlinelibrary.wiley.com

Matt Mattoni@mattmattoni.bsky.social · 10mo ago

🚨🚨New precision imaging study and open dataset 🚨🚨 Featuring almost 200 functional runs acquired in 3-4d intervals and behavioral manipulations focused on intraindividual study of the reward response - The Night Owls Scan Club (NOSC) With @dvsmith.bsky.social and @olinotom.bsky.social!

The CANDLab at Yale is hiring a new full-time research assistant! Excellent opportunity to gain post-bacc experience before applying to PhD programs in child and adolescent clinical psychology and neuroscience. 🧠 candlab.yale.edu/sites/default/files/downloads/YaleCANDLab_RA_2026.pdf

New preprint from the lab! Led by @martingell.bsky.social . There is something for everyone: brain-behavior prediction, latent variable modeling, test-retest reliability. 🧠📈📊 "Disentangling Brain-Psychopathology Associations: A Systematic Evaluation of Transdiagnostic Latent Factor Models"

Martin Gell@martingell.bsky.social · 5mo ago

🚨 New preprint alert! 🚨 Transdiagnostic latent factor models of psychopathology are widely assumed to improve brain-behaviour associations. So we decided to test this directly and found that they don't. A short 🧵 Link: www.biorxiv.org/content/10.6... 1/10

Brain scans do not help here

David Didau@didau.bsky.social · 6mo ago

Do brain scans tell us anything about how to structure a curriculum? Should we be lead by what cognitive psychology indicates about how we learn or by what neuroscience suggests about how knowledge is stored? open.substack.com/pub/daviddid...

Many thanks to @mattmattoni.bsky.social for presenting his interesting work in persons vs. people neuroscience this afternoon at @unirdg-cinn.bsky.social Read Matt's wise and varied papers: scholar.google.com/citations?hl...

New paper & a thread on the results 👇 ‘Reward-specific learning parameters change across normative adolescent development and are blunted in youth with high risk for depression’ acamh-onlinelibrary-wiley-com.ezp3.lib.umn.edu/doi/full/10....

Update: now it feels personal

Matt Mattoni@mattmattoni.bsky.social · 9mo ago

In the big 2026 can we agree to not require a seperate document for all these items that are already in the manuscript file

In the big 2026 can we agree to not require a seperate document for all these items that are already in the manuscript file

Check out this cool new experimental study by Jonas Dora, et al on the effects of negative mood ☹️ and alcohol intoxication 🍺🍸on reinforcement learning!!

Jonas Dora@jonasdora.bsky.social · 9mo ago

Our experimental study on the effects of negative mood and alcohol intoxication on reinforcement learning in the Iowa Gambling Task is now published OA in Judgment and Decision Making: doi.org/10.1017/jdm.... as always, anonymized data, materials, and code can be found on the OSF: osf.io/ky3aj/

I was fortunate to write this paper with some of the smartest and most courageous folks in any room: @lluaces.bsky.social @sheilacrowell.bsky.social @junegruber.bsky.social @tinaboisseau.bsky.social @anthonyperillo.bsky.social @jenperillo.bsky.social @cdelawalla.bsky.social 9/9

Just accepted at Nature Mental Health: Crises and Opportunities for Psychological Science under Fascism https://doi.org/10.31234/osf.io/nz42x_v3 1/9

Lauren S. Hallion, Ph.D.@laurenshallion.bsky.social · 9mo ago

Psychological science is in crisis. We are losing funding, fighting uphill against censorship, and watching as our students, colleagues, neighbors, and friends are attacked because of their nationality, gender expression, or skin color. Such is life under fascism. 2/9

🆕 New open neuroimaging dataset released! I’m happy to share that our Naturalistic Neuroimaging Database (NNDb3T+) is now publicly available! NNDb3T+ captures rich, multimodal brain activity in a naturalistic setting with 40 participants and over 160 hours of scanning!

Why do brain networks vary? Do these differences shape behavior? If every 🧠 is unique, how can we detect common features of brain organization? @rodbraga.bsky.social and I dig in, in @annualreviews.bsky.social (ahead of print): go.illinois.edu/Gratton2025-... #neuroskyence #psychscisky #MedSky 🧵👇

Dense Phenotyping of Human Brain Network Organization Using Precision fMRI

The advent of noninvasive imaging methods like functional magnetic resonance imaging (fMRI) transformed cognitive neuroscience, providing insights into large-scale brain networks and their link to cog...

go.illinois.edu

🧵8 We focused on fMRI studies of 🧠 networks… but there’s so much more neat idiographic work being done in other neuroimaging & psychology domains! See @mattmattoni.bsky.social's recent review for more thoughts on uniting these perspectives www.sciencedirect.com/science/arti...

Group-to-individual generalizability and individual-level inferences in cognitive neuroscience

Much of cognitive neuroscience research is focused on group-averages and interindividual brain-behavior associations. However, many theories core to t…

sciencedirect.com

New work led by @mattmattoni.bsky.social “Overall, results suggest that BOLD activation to reward tasks, and likely other fMRI tasks, is more appropriate for within-person study than between-person study, highlighting a need for intensive longitudinal neuroimaging designs.”

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 10mo ago

Precision Imaging for Intraindividual Investigation of the Reward Response https://www.biorxiv.org/content/10.1101/2025.09.26.678878v1

🚨🚨New precision imaging study and open dataset 🚨🚨 Featuring almost 200 functional runs acquired in 3-4d intervals and behavioral manipulations focused on intraindividual study of the reward response - The Night Owls Scan Club (NOSC) With @dvsmith.bsky.social and @olinotom.bsky.social!

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 10mo ago

Precision Imaging for Intraindividual Investigation of the Reward Response https://www.biorxiv.org/content/10.1101/2025.09.26.678878v1

This may be the most important paper ever published about NIH funded research. www.science.org/doi/10.1126/...

What if NIH had been 40% smaller?

Replaying history with less NIH funding shows widespread impacts on drug-linked research

science.org

Delighted that PINE Lab will be accepting applications for PhD students to start Fall 2026! Please share with applicants looking for developmental & neuroscience programs? Our website is updated with current studies, questions, and guidance about fit: www.plasticityinneurodevelopmentlab.com/join-us

Final version!

Imaging Neuroscience@imagingneurosci.bsky.social · 12mo ago

New paper in Imaging Neuroscience by Matthew Mattoni, Thomas M. Olino, et al: Functional connectivity heterogeneity and consequences for clinical and cognitive prediction: Stage 2 registered report doi.org/10.1162/IMAG...