Delighted to share our paper on neo-chromosomes! We induced centromere fission using CRISPR in Arabidopsis and increased the chromosome count from n=5 to n=6. The broken chromosomes ends quickly “healed” by adding telomeres de novo and the new karyotype is stable through mitosis and meiosis! 1/3

Ian Henderson@hendersi.bsky.social · 2w ago

CRISPR-mediated centromere fission generates neochromosomes with distorted meiotic inheritance in Arabidopsis biorxiv.org/content/10.6... new preprint from us - includes changing the Arabidopsis karyotype from 5 -> 6 chromosomes using Cas9 & outcomes of 5/6 chromosome hybrid meiosis

1 week until our next seminar! 🎉 Register here: www.efis-eline.eu/seminars

Early-life Immune Network Europe@efis-eline.bsky.social · 5mo ago

Save the date for our second seminar: April 2, 4 pm CET 🎤 Adrian Erlebacher - Mechanisms of parturition timing in mice 🎤 Dan Corral – Maternal Immune Regulation of Lactation Register here: www.efis-eline.eu/seminars #EarlyLifeImmunity #Immunology #EFIS

I’m excited to share our lab’s latest preprint, led by Joe Hutton. We take a deep look at monocytes in psoriatic arthritis (PsA), uncovering a population of circulating cells that are uniquely primed to become osteoclasts—cells responsible for breaking down bone. www.biorxiv.org/content/10.6...

Huge congratulations to our colleague, Mahlaqua Noor, for being recognised as one of this year’s 21toWatch winners. An outstanding achievement and so well deserved — we’re incredibly proud to have her on the team: www.cambridgemc.com/21towatch-20...

Nearly every baby is colonized by various E. coli at birth, but luckily only 1 in 1000 develops a severe infection: A new paper in Nature shows how maternal IgG specific to mum`s gut E.coli protects neonates. Read here: www.nature.com/articles/s41... #EFIS #ELINE #NeonatalImmmunology (1/7)

Natural maternal immunity protects neonates from Escherichia coli sepsis - Nature

Neonatal sepsis caused by Escherichia coli is associated with reduced transfer of pathogen-specific maternal antibodies and, in a mouse model, can be prevented by maternal preconceptual&nbsp...

nature.com

New exciting #NeonatalImmunology paper: Peripheral immune-inducer dendritic cells drive early-life allergic inflammation (1/5) www.nature.com/articles/s41...

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation - Nature

Early-life exposure to allergens triggers a distinct local mode of dendritic cell activation in neonatal skin without requiring migration to lymph nodes, which shapes responses to allergens in later l...

nature.com

Passionate about science? Looking for a new exciting role? Then join our team. This post has just opened: www.cam.ac.uk/jobs/researc...

We are excited to kick-off of our seminar series on March 5, 4pm CET 🥳 🎤 Petter Brodin – A seeding reaction to colonizing microbes in human newborns 🎤 Eva Stange – Neonatal liver niches program T cell tolerance Register here: www.efis-eline.eu/seminars #EarlyLifeImmunity #Immunology #EFIS

EFIS-ELINE - Seminars

Seminars run on the first Thursday of every month at 16:00 CET. We kick off with a 15-minute spotlight talk from an early-career researcher, then a senior scientist takes the stage for a deeper dive, ...

efis-eline.eu

I would like to share the launch of ELINE – the Early Life Immunity Network Europe. The seminar series takes place on the first Thursday of each month, starting on March 5th @ 16:00 CET Our first speakers are Eva Stange & Petter Brodin Registration: www.efis-eline.eu/seminars

EFIS-ELINE - Seminars

Seminars run on the first Thursday of every month at 16:00 CET. We kick off with a 15-minute spotlight talk from an early-career researcher, then a senior scientist takes the stage for a deeper dive, ...

efis-eline.eu

Calling all postdocs / early career researchers! The Loke CTR Next Generation Fellowship is a stepping stone to research independence! Visit 🔗 www.trophoblast.cam.ac.uk/next-generat... Need guidance to find a research sponsor? Register your interest via our short form forms.office.com/e/vST36RSB96

Looking to pursue cutting-edge research in early development, maternal-fetal interaction, or placental biology? See 👇 - Funded PhD www.trophoblast.cam.ac.uk/phd-students... - Next Generation Fellowship www.trophoblast.cam.ac.uk/next-generat... - MPhil www.mphil.bio.cam.ac.uk/mphil-pathwa...

Applications are open for the Next Generation Fellowship – applications until 30 January 2026 www.trophoblast.cam.ac.uk/next-generat...

Applications are open! For anyone looking to pursue a PhD in cutting-edge research in early development, maternal-fetal interaction, or placental biology: www.trophoblast.cam.ac.uk/phd-students...

An insight into advances in the field of placental biology and their importance: www.nature.com/articles/d41...

The mini placentas and ovaries revealing the basics of women’s health

Lab-made organoids that mimic reproductive tissues could point to treatments for common conditions such as pre-eclampsia and endometriosis.

nature.com

Great to see this out for all to see after a lot of hard work by @lizihegarty.bsky.social and @bainlab.bsky.social. Colonic #macrophages persist but are transcriptionally altered post- #inflammation in a mouse model of #colitis.

bioRxiv Immunology@biorxiv-immuno.bsky.social · 11mo ago

Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair https://www.biorxiv.org/content/10.1101/2025.09.19.677333v1

🚨 New in @natimmunol.nature.com : @idoyagalab.bsky.social shows that plasmacytoid DCs can reprogram into cDC2s after TNF-α stimulation. Fascinating plasticity! 👇 www.nature.com/articles/s41...

TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells - Nature Immunology

Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells. Here the authors show how...

nature.com

Are you a postdoc interested in the mechanisms of disease? Do you have a great record and an exciting vision? Come and start your own lab @dunnschool.bsky.social by applying for sponsorship for early career fellowships. Deadline 30th September...pass it on! www.path.ox.ac.uk/work-with-us...

Group Leader Career Development Fellowships - Dunn School

Are you an early career researcher interested in the cell or molecular mechanisms underlying disease? Do you have an outstanding record and an innovative research plan?

path.ox.ac.uk

This is a second video shows Listeria monocytogenes (green) recruiting host cell actin (red) in term Hofbauer cells. Created by Nagisa Yoshida

Here is a video from our manuscript capturing Hofbauer cells interacting with each other in placental villi explants

Happy share this latest study from the team. Here we look at placental macrophage biology across pregnany and their interaction with Listeria monocytogenes. www.science.org/doi/10.1126/...

Interactions between placental Hofbauer cells and L. monocytogenes change throughout gestation

Gestational changes in Hofbauer cells alter their interactions with Listeria monocytogenes.

science.org

Congratulations to @drbmalengier.bsky.social, @magmarlene.bsky.social and Team Gentek of @edinuni-irr.bsky.social for this amazing tour de force, comprehensively characterising #synovial #macrophage #development 💪🏻

bioRxiv Immunology@biorxiv-immuno.bsky.social · last yr.

The synovial lining macrophage layer develops in the first weeks of life in a CSF1- and TGFβ- dependent but monocyte-independent process. https://www.biorxiv.org/content/10.1101/2025.05.21.655269v1

NIH’s new director Jay Bhattacharya discusses staff morale, grant cuts, and “rumors” in an interview with Science. scim.ag/4mhSMpA

‘It’s been a tough period’: NIH’s new director speaks with Science

Jay Bhattacharya discusses staff morale, grant cuts, and “rumors”

scim.ag

Want to join us in the field of placental biology? Check out this postdoc position available in my lab in collaboration with Catherin Aiken. Research Assistant/ Research Associate in Placental Biology (Fixed Term) - Job Opportunities - University of Cambridge

Thrilled to share that our paper is now published in Immunity @cp-immunity.bsky.social ! 🎉 It’s been a long journey, and I’m incredibly grateful to all my co-authors—especially Dr. Teruyuki_Sano—for your dedication. This wouldn’t have been possible without you! www.cell.com/immunity/ful...

IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasis

Immune-microbiota interactions are required to maintain host homeostasis. Kim et al. identified that steady-state sensing of IL-10 by interstitial macrophages (IMs) prevents spontaneous lung inflammat...

cell.com

Want to join us in the field of placental biology? Check out this postdoc position available in my lab in collaboration with Catherin Aiken. Research Assistant/ Research Associate in Placental Biology (Fixed Term) - Job Opportunities - University of Cambridge

A new Science study reveals genetic links between pelvic structure and function, locomotion, and childbirth outcomes. The findings offer fresh insights into how our species evolved to balance the competing demands of bipedalism and childbirth. scim.ag/3Y2lQHb

The genetic architecture of and evolutionary constraints on the human pelvic form

Human pelvic evolution following the human-chimpanzee divergence is thought to result in an obstetrical dilemma, a mismatch between large infant brains and narrowed female birth canals, but empirical ...

scim.ag

🔬 Does your research explore placental ageing, senescence, prolonged pregnancy, or term complications like pre-eclampsia? Join leading experts at our Annual Meeting! Registration open, don’t miss your chance to be part of the discussion. www.trophoblast.cam.ac.uk/ctrconferenc...

Much of the Trump administration’s agenda for research is laid out in the 900-plus-page Project 2025. Nature examines science-related policies from Project 2025 that have already come to pass, and which ones might be on the horizon. 🧪

How Trump is following Project 2025’s radical roadmap to defund science

Much of the Trump administration’s agenda for research is laid out in the 900-plus-page blueprint. Nature read it so you don’t have to.

go.nature.com

Great to see the abstracts start to come in for EMDS2025. We have over 20 short talk slots up for grabs - with dedicated slots for #ECRs (PhD and postdocs). So, if you want to showcase your work to Europe's #macrophage #monocyte and #dendriticcell community, be sure to submit your abstract ASAP.

@emds2025.bsky.social · last yr.

Abstract Submission Open!! As we slide into the weekend, it's the ideal time to think about your abstract for #EMDS2025. Lots of opportunities for #ECRs to present...and prizes up for grabs! 👉 www.emds2025.com @britsocimm.bsky.social @cytokinesociety.bsky.social @societymucosalimm.bsky.social