Macrophages play roles far beyond their classical phagocytic characteristics - here Gonzalez Lopez et al show that #macrophages play a key role in #tooth #development and their disruption results in abnormal dentition, eruption and patterning. Very cool! www.nature.com/articles/s41...

Embryonic and postnatal macrophages are necessary for proper tooth development and homeostasis - Nature Communications

Our study establishes macrophages as necessary components of the developing tooth microenvironment to maintain their morphology and function. By integrating complementary experimental approaches, we s...

nature.com

Do the mammary, salivary, lacrimal and prostate #glands share a conserved fetal-like reversion during #regeneration? A great review addressing this question by @robinjournot.bsky.social, @candice-merle.bsky.social & @frelab.bsky.social of @institutcurie.bsky.social

Silvia Fre lab@frelab.bsky.social · last mo.

Week-end reading? Check out our new review on development and regeneration of glandular epithelia! With two fantastic co-authors: @robinjournot.bsky.social and @candice-merle.bsky.social ! 🤗 authors.elsevier.com/sd/article/S...

Last night we had the pleasure of watching Laura Arbanas, who is doing her #PhD with @aidarodrigo.bsky.social at @edinuni-irr.bsky.social, give the most wonderful overview of the magnificent #axolotl as part of #pint26 @pintofscience.uk

A couple of weeks ago @lizihegarty.bsky.social & I recorded a #podcast discussing her findings that fixation time really matters when analysing #macrophages by #microscopy & a bit about our working relationship as #postdoc & PI. 🔗 to listen below. Part of the @exocrineglandbio.bsky.social series.

Emmerson Lab@emmersonlab-irr.bsky.social · 3mo ago

Do you fix your favourite tissue before imaging? Listen to @lizihegarty.bsky.social and @doctoremmerson.bsky.social talk to Juliana Amorim and Kerry Pernick about their recent #preprint investigating how fixation affects #macrophage visualisation open.spotify.com/episode/3D26...

Save the date! The 2027 BSDB Spring Meeting will take place on 19 - 22 April in Edinburgh. An exciting programme with a fantastic lineup of speakers showcasing developmental biology across scales! More details soon!

It was so nice to welcome @kyracampbelllab.bsky.social to Edinburgh and @edinuni-irr.bsky.social as our external seminar speaker yesterday. Thank you for a wonderful talk, great chat & cathartic moaning about funding challenges over dinner!

As we gain organisational momentum for the 2027 #exocrine #glands #gordonconference, our GRS chairs have been preparing #podcasts. Listen now for a great discussion around #immunology, #pathology & #translation from Sarah McCoy & Blake Warner. open.spotify.com/episode/1Lhs...

Pathology & Translational Advances in Salivary Gland Disease, a talk with Dr. McCoy and Dr. Warner

open.spotify.com

Women's voices have been curiously absent from the media coverage of the Epstein files. Kudos to @jkutzie.bsky.social for publishing this excellent piece. If you consider yourself to be an ally please take a moment to consider the impact of the ecosystem created by men at the top.

The boys’ club: How Epstein’s influence shaped the exclusion of women in STEM

In one email, an AI researcher suggested it’s “hard to be brilliant if you are worrying if you look fat or why another woman hates you.”

19thnews.org

When you share an office with the queen of the #axolotls (aidarodrigo.bsky.social) you also get to share the birthday joy! 🥳 Happy 2nd birthday to the OG axolotls (treats baked by Laura Arbanas and @cellysally.bsky.social’s daughter)

Our latest preprint, led by @lizihegarty.bsky.social & aided by @erinwatson.bsky.social shows that fixation time matters when it comes to visualising #macrophages in #salivarygland & other epithelia.We find 1hr allows detection of mac subsets while preserving architecture. With @bainlab.bsky.social

bioRxiv Immunology@biorxiv-immuno.bsky.social · 6mo ago

Fixation matters: duration in fixative prior to immunofluorescent analysis directly impacts macrophage visualisation in epithelial tissues https://www.biorxiv.org/content/10.64898/2026.02.13.705745v1

🧫 For anyone interested in doing a #PhD in #fertility preservation, #chemotherapy & #macrophages please see this opportunity at @edinuni-irr.bsky.social in #Edinburgh, supervised by Roseanne Rosario, @rodtmitchell.bsky.social & me. 💻 www.findaphd.com/phds/project... 📆 Closing date: 6th March

Targeting macrophages to protect fertility after chemotherapy at University of Edinburgh on FindAPhD.com

PhD Project - Targeting macrophages to protect fertility after chemotherapy at University of Edinburgh, listed on FindAPhD.com

findaphd.com

In recent days there have been a number of reports about cuts to UKRI budgets and grant funding pauses. www.sciencecampaign.org.uk/analysis-and...

What is happening with UKRI funding and the STFC cuts? - CaSE

In recent days there have been a number of reports about cuts to UKRI budgets and grant funding pauses. Here we summarise events so far, and set out why we believe UKRI should explain how and why deci...

sciencecampaign.org.uk

Some thoughts on the select committee appearance by the boss of UKRI, Ian Chapman yesterday. It’s a long watch but can be seen here: parliamentlive.tv/Event/Index/... Thread 🧵

Parliamentlive.tv

Science, Innovation and Technology Committee

parliamentlive.tv

V happy to share the latest collaborative effort between myself & Anthony Callanan, led by #PhDstudent Mary Heim, who characterised #macrophages in the irradiated #thyroid, and then developed electrospun scaffolds to locally modulate immune response. advanced.onlinelibrary.wiley.com/doi/10.1002/...

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Radiation-induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate th...

advanced.onlinelibrary.wiley.com

Immune cells adapt to distinct stem cell niches to govern tissue homeostasis https://www.biorxiv.org/content/10.64898/2026.01.28.701831v1

Very nice commentary of @lizihegarty.bsky.social’s recent paper in @mucosalimmunol.bsky.social by Florent Ginhoux and colleagues #macrophage #colon @bainlab.bsky.social

Mucosal Immunology@mucosalimmunol.bsky.social · 7mo ago

Colonic macrophage heterogeneity revealed by CD11c and CD163 www.mucosalimmunology.org/article/S193...

Great commentary of Fredi & @selmatuzlak.bsky.social’s Nature Immunology #adenophage paper, written by @steffenjung.bsky.social and colleagues. www.nature.com/articles/s41...

This collab started when I met Fredi at the 2023 #EMDS meeting. Since then it’s been wonderful working with her, @selmatuzlak.bsky.social & Burkhard to explore these GM-CSF dependent #macrophages in #glands. Delighted to see this published in @natimmunol.nature.com 🥳 www.nature.com/articles/s41...

Adenophages are an atypical macrophage population in exocrine glands sustained by ILC2-derived GM-CSF - Nature Immunology

Here the authors identify adenophages, a previously unknown macrophage population present in exocrine glands in mice and humans. These cells are dependent on ILC2-derived GM-CSF and support glandular ...

nature.com

Great to see #ECRs chairing sessions at @britsocimm.bsky.social #BSI25! Here’s our postdoc @lizihegarty.bsky.social excellently co-chairing the #neuroimmunology session alongside Jessica Teeling.

Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair in this work from @lizihegarty.bsky.social, @bainlab.bsky.social, and colleagues: www.mucosalimmunology.org/article/S193...

A common LGR5+ cell gives rise to the #tongue epithelium, the #tastebuds and the von Ebner #salivaryglands. A lovely study from @hansclevers.bsky.social and colleagues. www.nature.com/articles/s41...

Tripotent Lgr5 stem cells in the posterior tongue generate lingual, taste, and salivary gland lineages - Nature Communications

Here, the authors show that a single Lgr5 stem cell population in the posterior tongue produces taste buds, salivary glands, and epithelium, representing unified chemosensory units.

nature.com

If you work with #scRNAseq, #salivary, #thyroid or #mammary gland #organoids, or are interested in #irradiation and #Notch signaling, you might find this exciting! Our latest paper is now available in @embojournal.org! Check it out! Link below ✨ doi.org/10.1038/s443...

Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage | The EMBO Journal

imageimageRegulatory mechanisms governing stem cell quiescence in glandular organs remain ill-defined. Here, multi-omics profiling uncovers novel stem cell-like populations in mouse salivary gland organoids and reveals Notch signaling as a ...

doi.org

The EMBO Journal@embojournal.org · 9mo ago

Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage @davidecinat.bsky.social, Lara Barazzuol, Rob Coppes et al www.embopress.org/doi/full/10....

Extremely excited to see this out in @science.org Signaling! In this study, we explored the molecular differences between #photon and #proton irradiation and uncovered how #salivary gland stem cells respond to the resulting #inflammatory cues. www.science.org/doi/10.1126/...

IFN-I signaling enhances salivary gland stem and progenitor cell activity after irradiation

Regenerative responses in salivary gland organoids after irradiation are mediated by IFN-I signaling.

science.org

Delighted to share this! We identify gut #macrophages as key players in preventing dissemination of intestinal microbes in liver cirrhosis. Best collab with my partner in crime @lenasmets.bsky.social, featuring some stunning live imaging with @colindascheele.bsky.social 👇 gut.bmj.com/content/earl...

Intestinal blood vessel-associated macrophages and gut-vascular barrier dysfunction in cirrhosis

Background Bacterial translocation in cirrhosis can trigger infection and hepatic decompensation, leading to systemic inflammation, organ failure and increased mortality. These infections often origin...

gut.bmj.com

Thrilled for our wonderful postdoc @lizihegarty.bsky.social whose #PhD work on colonic #macrophages and #colitis with @bainlab.bsky.social @edinuni-irr.bsky.social has been accepted for publication in @mucosalimmunol.bsky.social 🔬 www.sciencedirect.com/science/arti...

Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair

Macrophages are crucial for the maintenance of intestinal homeostasis, are considered key proinflammatory effector cells during intestinal inflammatio…

sciencedirect.com

A beautiful study describing cell fate acquisition in bilayered #epithelia, inc. my fave #salivarygland, published in @cp-devcell.bsky.social Conserved signals control self-organization & symmetry breaking of murine bilayered epithelia during development & regeneration www.cell.com/developmenta...

Conserved signals control self-organization and symmetry breaking of murine bilayered epithelia during development and regeneration

Journot et al. explore fate specification during embryonic development and regeneration of bilayered glandular epithelia. They uncover conserved molecular mechanisms linking tissue architecture with c...

cell.com

Wonderful to see this lovely data out in @mucosalimmunol.bsky.social! Congratulations to @nabinapun.bsky.social, @douglaspdyer.bsky.social & colleagues of @lydiabeckeriii.bsky.social & @mcrcellmatrix.bsky.social! 👏 #monocyte #radiotherapy #intestinal #toxicity www.sciencedirect.com/science/arti...

CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity

Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to…

sciencedirect.com

Nice to spend the morning in the magnificent Playfair Library at @edinburgh-uni.bsky.social discussing how to better support #carers in #STEMM, organised by @carersinstemm.bsky.social, and with my very own dependent alongside me as it’s half term!

📖 A very comprehensive review of the heterogeneity, crosstalk and therapeutic potential of #salivarygland #macrophages including reference to several papers from @emmersonlab-irr.bsky.social 📚 #immunosky www.frontiersin.org/journals/imm...

Frontiers | Salivary gland macrophages in health and disease: heterogeneity, niche crosstalk, and therapeutic avenues

Salivary glands (SGs) produce saliva essential for digestion, mucosal immunity, and as a source of non-invasive biomarkers. The health and pathology of SGs h...

frontiersin.org

TGFb mediates #macrophage specialisation and crosstalk with sensory #nerves in the #skin after injury. A beautiful study by Julia Kolter, Philipp Henneke and colleagues published in @cp-immunity.bsky.social #immunosky www.cell.com/immunity/ful...

Sensory neurons shape local macrophage identity via TGF-β signaling

Specialized macrophages are known to persist within tissue niches, but the molecular mechanisms guiding their sustained functional adaptation remain unclear. Kolter and Döring et al. show that local i...

cell.com