Our new work exploring associations between childhood thoughts, feelings, and behaviors and the big 5 personality PGIs is now preprinted! www.medrxiv.org/content/10.6...

Childhood Correlates of Genetic Propensity to Personality Traits

The Big 5 personality traits (extraversion, agreeableness, conscientiousness, neuroticism, openness to experience) are moderately heritable correlates of behavior, health, and life outcomes. Character...

medrxiv.org

🚨 New Preprint out! What if psychosis is not a single, homogeneous construct? "Parsing the functional heterogeneity of psychosis spectrum" addresses this question defining a genetic gradient across the spectrum. 🧬 www.medrxiv.org/content/10.6...

Parsing the Functional Heterogeneity of the Psychosis Spectrum: A Clinically Informed Application of Genomic Structural Equation Modeling

Schizophrenia, bipolar disorder, and major depression vary in their age of onset, cognitive impacts, degree of impairment, and clinical course. However, since psychosis is a transdiagnostic feature th...

medrxiv.org

Out today with @tedmond.bsky.social, our research briefing summarizing key takeaways from our Big Five GWAS! www.nature.com/articles/d41...

Genetic associations with the Big Five personality traits probed in one million people

Links between genetic variants and personality differences are robust, complex and related to health, career and relationship outcomes.

nature.com

Some coverage of our Big Five GWAS! (with quotes by @tuckerdrob.bsky.social) After reading the comments section I am now in favor of compulsory psychometrics education.

Scientists Find More Than 1,000 DNA Variants Linked to Personality Traits (Gift Article)

More than one million genomes helped identify DNA variants linked to extroversion, agreeableness, neuroticism and more. Researchers measured how those traits influenced how people lived.

nytimes.com

🚨& 🧵 Our new Nature paper is out! Across 46 cohorts and up to 1.14M people per Big Five trait, we do GWAS and ask how robust, generalizable and consequential the genetic signals underlying personality really are. www.nature.com/articles/s41...

Studies RFK Jr canceled: -Training rural healthcare workers to better respond to maternal medical emergencies -Improving healthcare delivery systems for patients to access home dialysis -Improving autism screening, diagnosis, & services among Black children www.medpagetoday.com/washington-w...

Senators Blast RFK Jr. Over AHRQ Grant Cancellations

'We demand that you immediately rescind these cancellations,' says group of Democrats

medpagetoday.com

1/9 🚨 BREAKING OUT OF STEALTH MODE 🚨 Multivariate GWAS in Genomic SEM now runs on a laptop! New preprint + package update: a closed-form analytic solution makes multivariate GWAS ~800× faster, cutting runtimes from hours on HPC clusters to minutes on a personal computer.

The Predator Emerges

ALT: The Predator Emerges

static.klipy.com

This reviewer is a perfect illustration of a person with good intentions, who I probably agree with on a ton of things, who starts from the premise that "it is bad if things are partially heritable, so they cannot be" and then works from there. Acknowledging genetics is not endorsing eugenics!

Natural Election | Los Angeles Review of Books

Kathryn Paige Harden’s new book offers a defense of a kind of Scientific Calvinism that converges with the eugenicist ideals of the contemporary Far Right.

lareviewofbooks.org

New post! "Valuing the Process vs. the Product in Research," in which I try to describe some of the tensions around using GenAI/LLMs in scientific research, and why it can be so difficult to have productive conversations on the topic. getsyeducated.substack.com/p/valuing-th...

Valuing the Process vs. the Product in Research

On reasonable resistance to using GenAI in research

getsyeducated.substack.com

Newsletter up. Rant incoming. Pop sci mostly reaches educated, left-leaning, wealthy readers — including, of course, scientists and science writers. I increasingly believe the gap between the real general audience and what's called "general audience" in scicomm is huge and worth talking about: 🧪

Pop science doesn't reach a "general audience"

Pop sci readers are wealthy, educated, and left-leaning

reviewertoo.com

1/ 🚨New paper in Nature Genetics Genetic factors are associated with the educational fields people study, from arts to engineering. Article: www.nature.com/articles/s41... FAQ: www.thehastingscenter.org/genomic-find...

Genetic associations with educational fields - Nature Genetics

Genome-wide analyses of 10 educational fields identify 17 associated loci. Analysis of genetic clustering across specializations identifies two key dimensions that show genetic overlap with personalit...

nature.com

We have an open postdoc position in Social Science Genomics in Berlin! Includes gene-environment interplay within German population cohorts & experimental online survey studies to probe public perceptions of potential DNA biomarker applications 🔗 www.mpib-berlin.mpg.de/2196134/2025...

Postdoctoral Position in Social Science Genomics | Max Planck Research Group Biosocial

mpib-berlin.mpg.de

Non-paywalled link to my commentary on @vw1234.bsky.social and colleagues new paper in @nature.com rdcu.be/eI2NG

Varun Warrier@vw1234.bsky.social · last yr.

This was a fantastic collaboration with lots of people including @hilarycmartin.bsky.social @jakobgrove.bsky.social, Experts by Experience, and several others who I can't seem to find on this app. Article: www.nature.com/articles/s41...

A deep and thought-provoking lecture that is definitely worth watching all the way through.

Eric Turkheimer@ent3c.bsky.social · last yr.

My Dobzhansky lecture at BGA: "Theodosius Dobzhansky and the Origins of Radical Behavior Genetics" is publicly available. I talk about the tensions introduced into the field at the difficult border between science using model organisms and human beings. Thanks to BGA for the opportunity.

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41... (feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)

Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex - Nature Genetics

Genomic structural invariance, an extension of genomic structural equation modeling, identifies similarities and differences between males and females in the genetic architectures of eight psychiatric...

nature.com

Are mental disorders extreme manifestations of continuous traits or genetically distinct entities? We present Genomic Taxometric Analysis of Continuous and Case-Control data (GTACCC) for evaluating genetic continuity and differentiation of traits across the severity spectrum. Tweetorial coming soon.

🚨 New paper! In this review, we explore factor indeterminacy and outline how we can use genetic data to test the validity of latent factors. tinyurl.com/5n75446y With @tedmond.bsky.social , @tuckerdrob.bsky.social , @kph3k.bsky.social , @andrewgrotzinger.bsky.social , and @michelnivard.bsky.social

Beyond the factor indeterminacy problem using genome-wide association data - Nature Human Behaviour

The authors address the central criticism of latent variable models in behavioural science, which is that a wide range of causal models may account for the observed data (the factor indeterminacy prob...

nature.com