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Christine Mayr

@christinemayr.bsky.social

Scientist interested in 3’UTRs and mRNA-based translation environments. We study how mRNAs regulate IDR conformations and protein functions. MSKCC in NYC

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Christine Mayr@christinemayr.bsky.social · 2mo ago

Jim Shorter and his postdoc Miriam wrote a beautiful preview about our most recent paper on mRNAs preventing misfolding of IDR-containing proteins. UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins: Cell www.cell.com/cell/fulltex...

UTR-ly unexpected: RNA chaperones tame intrinsically disordered proteins

How do cells ensure that complex, multidomain proteins fold correctly? Luo et al. reveal a self-contained solution. The 3′UTR of an mRNA co-translationally chaperones the protein it encodes, preventin...

cell.com

Christine Mayr@christinemayr.bsky.social · 3mo ago

Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...

mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity

Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.

cell.com

Junjie Guo@junjieguo.bsky.social · 4mo ago

Check out the phenomenal PhD work by Katie Copley, a current postdoc in our lab @yaleneuro.bsky.social @yalerna.bsky.social. www.science.org/doi/10.1126/...

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how sho...

science.org

Lori Passmore@lapassmore.bsky.social · 5mo ago

Very importantly, one of the co-organisers @xrnchew.bsky.social is cycling to the meeting to raise awareness and funds for 'All things small and green' . Please join him or sponsor him! gofund.me/f4068dc3c

Donate to Cycling from Exeter to the 3' end (in Oxford)!, organized by Steven West

I'll be cycling from Exeter to Oxford (about 160 miles/260 km) - hopefully … Steven West needs your support for Cycling from Exeter to the 3' end (in Oxford)!

gofund.me

Christine Mayr@christinemayr.bsky.social · last yr.

New paper: More than 2700 human 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. www.biorxiv.org/content/10.1...

mRNA 3′UTRs chaperone intrinsically disordered regions to control protein activity

More than 2,700 human mRNA 3′UTRs have hundreds of highly conserved (HC) nucleotides, but their biological roles are unclear. Here, we show that mRNAs with HC 3′UTRs mostly encode proteins with long intrinsically disordered regions (IDRs), including MYC, UTX, and JMJD3. These proteins are only fully active when translated from mRNA templates that include their 3′UTRs, raising the possibility of functional interactions between 3′UTRs and IDRs. Rather than affecting protein abundance or localization, we find that HC 3′UTRs control transcriptional or histone demethylase activity through co-translationally determined protein oligomerization states that are kinetically stable. 3′UTR-dependent changes in protein folding require mRNA-IDR interactions, suggesting that mRNAs act as IDR chaperones. These mRNAs are multivalent, a biophysical RNA feature that enables their translation in network-like condensates, which provide favorable folding environments for proteins with long IDRs. These data indicate that the coding sequence is insufficient for the biogenesis of biologically active conformations of IDR-containing proteins and that RNA can catalyze protein folding. ### Competing Interest Statement The authors have declared no competing interest. Pershing Square Foundation, https://ror.org/04tce9s05 G. Harold & Leila Y. Mathers Foundation National Institutes of Health, DP1GM123454, R35GM144046 Memorial Sloan Kettering Cancer Center, https://ror.org/02yrq0923, P30 CA008748

biorxiv.org

@brangwynnelab.bsky.social · last yr.

What drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity, revealing impact of encoded protein function. Fantastic work from @lindsayabecker.bsky.social @sofiquinodoz.bsky.social @davidaknowles.bsky.social www.biorxiv.org/content/10.1...

Genome-wide mapping of mesoscale neuronal RNA organization and condensation

Subcellular RNA organization can affect critical cellular functions. However, our understanding of RNA microenvironments, particularly biomolecular condensates, remains limited, largely due to a lack ...

biorxiv.org

Nicoletta Petridou@nicolettapetridou.bsky.social · last yr.

Are material phase transitions more than simple regulators of tissue deformability? Check our latest work uncovering that rigidity transitions can trigger cell polarity! Congratulations to @laura-rustarazo.bsky.social , @crisp-c.bsky.social and Adrián for leading this work!

Laura Rustarazo-Calvo@laura-rustarazo.bsky.social · last yr.

🎉 Excited to share our new work: “Adhesion-driven tissue rigidification triggers epithelial cell polarity”, now on @biorxivpreprint.bsky.social ! A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌 🧵⤵️

Leo Schärfen@leoschaerfen.bsky.social · last yr.

Here is our paper showing in vivo folding of nascent RNA right after synthesis, published now in @cp-molcell.bsky.social! With @karlaneugebauer.bsky.social, @isaac-vock.bsky.social, @mattdsimon.bsky.social www.cell.com/molecular-ce...

Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis

Schärfen et al. develop a method to measure the structure of nascent RNAs during their synthesis by RNA polymerases. Base pairing occurs rapidly in cells, revealing the strong regulatory potential of ...

cell.com

Saarikangas lab@saarikangaslab.bsky.social · last yr.

Apply now for the Susan Lindquist School on Proteostasis EMBO-FEBS Lecture Course, 16-19 Sept 2025 in Espoo, Finland! Top speakers cover the latest in proteostasis. Open to 60 PhDs & postdocs. Deadline: 15 June 2025. meetings.embo.org/event/25-pro...

Susan Lindquist School on Proteostasis

Cells constantly surveil and monitor their proteome to ensure proper function. These processes, spanning multiple steps from protein synthesis to folding and degradation, are collectively known as pr…

meetings.embo.org