www.biorxiv.org/content/10.6... Mechanism of branched actin assembly at microtubule tips downstream of Adenomatous Polyposis Coli (APC) protein
Elias Spiliotis
@septinlab.bsky.social
Professor of Cell Biology (University of Virginia), Research Scientist. Science, music, sports and politics. Opinions are my own and not of my lab or university.
Just found out about Carnegie Embryology's closing at Hopkins. I did my first grad school rotation there with Andy Fire & Yixian Zheng. And took the legendary Molecular Morphogenesis course. It was such a jolt. The smell of this place is still in my head. Sad. www.bizjournals.com/baltimore/ne...
Storied research institute leaves Hopkins campus after 100 years - Baltimore Business Journal
After over 100 years of research that led to a Nobel Prize and dozens of other discoveries, one of the world's top research institutions is leaving Baltimore.
bizjournals.com
Carolyn Ott @hhmijanelia.bsky.social, Jennifer Lippincott-Schwartz & David Breslow @davidbreslowlab.bsky.social explain how recent advances have expanded our models of primary cilia disassemble and discuss emerging roles of altered disassembly in disease. journals.biologists.com/jcs/article/...
All registration deadlines are listed below. Stay tuned for more posts about our other invited speaker, Dr. Matthew Tyska, and our Keynote speaker, Dr. James Sellers! We are excited to see you at this year's meeting! Please reach out to tcdrm.info@gmail.com with any questions. (3/3)
SEPT9 is a septin amplified in breast cancer. The Spiliotis lab combines live imaging of confined migrating cells, Clinicogenomic data, and more to tease apart SEPT9's mechanoprotective role. Register to hear more about this exciting research at this year's TCM: forms.gle/QGELSmPhAMGK... (2/3)
2026 Triangle Cytoskeleton Registration
Thank you for your interest in the 2026 Triangle Cytoskeleton Meeting! Please fill out the information in the form below. To finish registration and pay for attendance please go to: ...
forms.gle
Looking foreword to visit and present in North Carolina! And grateful for the invitation 🙏
Have you ever wondered how cells protect their nuclei from damage while squeezing through tightly packed tissues? @septinlab.bsky.social at the University of Virginia have! Dr. Elias Spiliotis will share how septin filaments anchor and protect nuclei during migration at TCM 2026! (1/3)
I just discovered my 140 record reviews as a dj at Stanford's KZSU (ca 2002-2008) If I never get to that number of publications, please throw me a retirement as a "music writer"... zookeeper.stanford.edu:8443?action=viewR...
zookeeper.stanford.edu
www.sciencedirect.com/science/arti... The actin crosslinker Fimbrin is required for force sensing at tricellular junctions
The second July issue is online: link.springer.com/journal/4431... The cover features work by Naoyuki Inagaki, Kio Yagami and colleagues from NAIST describing spontaneous membrane protrusion and cell morphogenesis via self-propelled #actin filaments. -> link.springer.com/article/10.1...
Hot off the press!! 🚨 Our work is now published in #NatureCommunications! We show that keeping tubulin levels in check is key for preserving microtubule dynamics, multicellular architecture and viability. A huge thank you to the @ivanagasic.bsky.social team for making this possible! 🙌 rdcu.be/fu8ek
Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viability
Nature Communications - Almeida AC et al. uncover the physiological role of a long-elusive feedback pathway that regulates tubulin biosynthesis. By tuning microtubule dynamics, this mechanism...
rdcu.be
This Turkish yogurt cake is similar to a lemon-scented cheesecake, but it’s lighter and has a fresher, tangier flavor. nyti.ms/4fcwnZf
Yogurt Cake Recipe • 4★
This Turkish yogurt cake, adapted from the cookbook “Claudia Roden’s Mediterranean,” is similar to a lemon-scented cheesecake, but it’s lighter and has a fresher, tangier flavor. It’s good both warm and cold, either on its own or topped with berries that have been macerated in a pinch or two of sugar.
nyti.ms
If you type "Journal of Cell Biology" in google search box and hit enter... this is the result:
O' clathrin vesicle, where art thou? And COPI and COPII...?
As the World Cup final approaches, take a moment to appreciate the beautiful symmetries of humanity’s favorite truncated icosahedron: the soccer ball.
From Beastie Boy Mike D's upcoming solo album... first music in 15 years Welcome back Mike D - hope for new with Adam next www.youtube.com/watch?v=ssKf...
Mike D - True Colors (Visualizer)
YouTube video by MikeDMusicVEVO
youtube.com
Inorganic phosphate rapidly switches the stability of Arp2/3-induced actin branches rupress.org/jcb/article/...
🧵 New paper alert! Today on bioRxiv, we show how a microtubule (MT) associated protein, MTCL1, links 2 regulatory layers: mechanical MT stabilization and writing of then tubulin code. A multi-lab effort driven by Juan Perez-Bertoldi and Julie Dang spanning atoms to organisms. 1/n
I caught this great interview with legendary guitarist Lenny Kaye while driving yesterday. Brilliant quote by Patti Smith: "Progress isn't the future, it's keeping up with the present." www.npr.org/2026/07/09/n...
'Music belongs to the moment': Patti Smith's guitarist Lenny Kaye is 'Goin' Local'
Kaye's collaboration with Smith began in 1971 and continues to this day. He says she taught him to trust his musical sensibilities — and to always keep evolving. Now 79, he has his first solo album.
npr.org
www.biorxiv.org/content/10.6... Unbranched SPIN90-Arp2/3 actin promotes stress fiber speed and focal adhesion maturation
www.biorxiv.org/content/10.1... Multiple evolutionary routes to cytoskeletal arborization revealed by the rhizarian amoeba Filoreta ramosa
Quebec defeats United States — look at that CROWD!
Angine de Poitrine - Yor Zarad - Montreal International Jazz Festival - June 27, 2026
YouTube video by Sopmylo
youtube.com
www.molbiolcell.org/doi/10.1091/...
Non-muscle Myosin II acts as a negative feedback mediator to control cell contraction dynamics in adherent cells | Molecular Biology of the Cell
Pulsatile cell contraction dynamics play a crucial role in tissue and cell morphogenesis. Previously, we identified a signal network in adherent mammalian cells, that can transduce mechanical signals ...
molbiolcell.org
Hey #nucleus nerds, the JCS Special Issue on the Cell Biology of the Nucleus is now live! This was a pleasure to co-edit with Megan King @luskinglab.bsky.social.
Our Special Issue: Cell Biology of the Nucleus is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows the posteriorly positioned nuclei (Nup50-mCherry - pink) of notochord cells in Ciona embryos. See article by Peng et al. journals.biologists.com/jcs/article/...
Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin rupress.org/jcb/article/...
"...rejected by Cell after one reviewer said SpudCells were not real biology... then sent the 190-page manuscript to journalists, under embargo, even before uploaded it to bioRxiv... She says her group will submit it to a new journal soon." www.science.org/content/arti...
Lab-created ‘SpudCell’ marks ‘stunning’ step toward building life from scratch
A synthetic cell can now grow and divide—but it’s still far from alive
science.org
New Grotjahn lab preprint from superstar postdoc @nitishdua.bsky.social! Check out all the deets in the 🧵 below. IMO, it’s a great example of how studying the local microenvironment with #teamtomo can reveal biology that would otherwise remain hidden. #mitochondria #morphometrics
Really hyped to share our pre-print on mtDNA replication-fission ! @nanigrotjahn.bsky.social (doi: doi.org/10.64898/202...) 🧵with details below ⤵️
Air Hill, and priceless and rare ear-to-ear Wheeler smile! #SeasonHighlight