In #GENETICS, Ananthaswamy et al. used the #Celegans oocyte model to identify the functions of nucleosome remodeling and deacetylase (NuRD) complex in the repair of endogenous double-strand breaks and exogenous DNA lesions. buff.ly/gFOnT8H
Marc Perry
@mdperry.bsky.social
Biochemist (by training), Geneticist (by osmosis), Bioinformatician (by experience). Possesses an extremely peculiar sense of humor/humour.
Early resolution of sister chromatids during #Celegans #meiosis. New study from Antonia Hamrick and Ofer Rog @theroglab.bsky.social @uofubiology.bsky.social: rupress.org/jcb/article/... #Chromatin #epigenetics #Genetics #CellCycle #CellDivision
I've been writing Advent Calendar posts about Pixie the Elf for a few years now. So I thought it was time she had her own website. pixie.perlhacks.com
Pixie the Elf writes Perl
Pixie the Elf is a cheerful Perl hacker at the North Pole. This page collects all of her Perl Advent calendar stories in one place.
pixie.perlhacks.com
I've always loved the openness and collegiality of our C. elegans community 🪱, but this perspective really helps emphasize just *how important* those traits are for scientific progress. A true tribute to how curiosity-driven science leads to innovation! 🙌
Oded Rechavi@odedrechavi.bsky.social · 9mo agoRead this inspiring perspectives coauthored by the Worm Resource directors and worm Nobel Laureates! 4 Nobel Prizes and how they were enabled by major NIH-supported research resources (the Caenorhabditis Genetics Center, WormBase, and WormAtlas) www.pnas.org/doi/10.1073/...
A potent and plain-spoken defence of DEI in science - from the experts. Representation *matters*.
Needhi Bhalla 💅🏽@needhibhalla.bsky.social · 10mo ago@joann-trejo.bsky.social, @marymunson4.bsky.social and I have a commentary in @natcellbio.nature.com on recent attacks on DEI in biomedical research: "If scientific research, especially biomedical research, is meant to serve everyone, then it requires that everyone has an opportunity to participate"
John Clarke, Michel Devoret and John Martinis have been awarded the 2025 Nobel Prize in Physics for demonstrating quantum physics on the macroscopic scale, which has paved the way for quantum computing. ⚛️🧪
Groundbreaking quantum-tunnelling experiments win physics Nobel
John Clarke, Michel Devoret and John Martinis discovered quantum physics on a macroscopic scale, paving the way for quantum computing.
go.nature.com
Are you an early career scientist who wants to get specialist training in C. elegans model for your laboratory research? we co-organize again the EMBO C. elegans course! Do not miss applying!
EMBL Events@events.embl.org · 11mo ago🪱 Ready to take your C. elegans skills to the next level? Join our #EMBOCelegans course! 🎯 Learn hands-on genome editing, AI-driven imaging, microfluidics & uncover development, physiology & evolutionary insights. 📍 EMBL Heidelberg 📅 23 – 29 Mar 2026 👉 Apply by 8 Dec: s.embl.org/cel26-01-bl
Pervasive homeobox gene function in the male-specific nervous system of Caenorhabditis elegans journals.biologists.com/dev/article/...
Fun fact: diluted tattoo inks and washes make pretty decent carbon sources for NTMs.
Joseph Marcus@josephmarcusid.medsky.social · 12mo agoEight of 63 clients of a tattoo artist using a homemade (witch hazel-based) diluent developed an NTM skin and soft tissue infection. Just say no to 🙅♂️homemade tattoo ink #IDSky academic.oup.com/cid/advance-...
You had me at "supergiant cannibals." 😱 Gotta love the world of ciliates. Good🧵⬇️
Ben Larson@blarson.bsky.social · 12mo agoWhat could be more exciting than watching Euplotes scurry around under the microscope? How about adding some raptorial predation by supergiant cannibal cells? www.biorxiv.org/content/10.1... Video by Vittorio Boscaro. 1/n
As a member of the Toronto Perl Mongers I volunteered at the TPRC held in Toronto in 2023. This blog post from Bryan Katz relates his experience with Perl in general, and specifically at that conference #relatable #perl www.perl.com/article/my-g...
My Guilty Perl Obsession
Perl came for free. How much have I contributed in return? Absolutely nothing.
perl.com
Exciting new study showing extensive Argonaute protein family gain, loss, neofunctionalization + more among species, by PhD student Daniel Fusca with @katjakasimatis.bsky.social + Hongyu Zhu; Now out @genomebiolevol.bsky.social #celegans #rna doi.org/10.1093/gbe/...
Dynamic Birth and Death of Argonaute Gene Family Functional Repertoire Across Caenorhabditis Nematodes
Abstract. Diverse small RNA pathways, composed of Argonaute effector proteins and their bound small RNA molecules, define critical systems for regulating g
doi.org
Pervasive homeobox gene function in the male-specific nervous system of Caenorhabditis elegans https://www.biorxiv.org/content/10.1101/2025.05.13.653874v1
Alternative splicing across the C. elegans nervous system www.nature.com/articles/s41...
Alternative splicing across the C. elegans nervous system - Nature Communications
By affecting which form of a gene is expressed, alternative splicing is a major source of diversity in the nervous system. Here, the authors present an atlas of splice variants across neurons, and exp...
nature.com
Whoah!!
W. Brent Derry@wbderry.bsky.social · last yr.I am pleased to share our latest manuscript, a collaboration with my @sickkidsto.bsky.socical colleague Dr. Ran Kafri. Led by PhD student Rachel Webster, who found that the CDK4/Rb/E2F pathway regulates metabolism to prevent premature aging in C. elegans. www.nature.com/articles/s41...
The Provisional Mortality statistics have been updated by the Australian Bureau of Statistics (ABS), up to January 2025. Here are the deaths where the underlying cause of death was certified by a doctor as COVID-19 (22,357 deaths). #COVID19 #Australia 🧵
The US has cut the equivalent of 3X the total annual CIHR budget so far this year, revealing both how low the CIHR budget is and how utterly draconian the White House has treated one of the most precious and successful institutions the US has ever built.
Jeremy Berg@jeremymberg.bsky.social · last yr.Update of my analysis of funding missing in FY2025 compared to FY2024. Bottom line: The missing amount is estimated to be $2.05 B from non-competitive renewals and $0.83 B from new and competitive renewals. Total: $2.88 B
Huge thanks to Federico Gueli for his tips on new lineages to watch out for, eg bsky.app/profile/siam... 🧵
Federico Gueli@siamosolocani.bsky.social · last yr.One SC2 variant that i see usually overlooked is XFC that is basically LP.8.1.1 with the NTD from LF.7 , interestingly it has been sampled two times in travelers coming into US from Ethiopia in a period spanning four months suggesting it may have high prevalence there along with XFJ .
@augustorendon.bsky.social It was such a good idea now everyone is copying you. Who knew?
Shicheng Guo@shihcheng.bsky.social · last yr.🇨🇦 Canada is sequencing 100,000 genomes to revolutionize healthcare. From rare diseases to drug safety in kids, this $200M effort will drive AI-powered precision health—and ensure breakthroughs reflect Canada’s diverse population. It's our turn. #Genomics genomecanada.ca/how-100000-g...
🪱 Worm people! C. elegans Mentor Match sign-ups close May 8: 👩🔬 Be matched with a mentor → custom career guidance 🤝 Join a peer group → swap tips & stay accountable ✨ Both → double support Tell your lab mates and help us grow the program!
Mentee sign-up for the 2025 C. elegans Community Mentor Match program
The 2025 C. elegans Community Mentor Match is open to graduate students, postdocs, and faculty at any career stage. This survey collects information to help the committee (a) identify the most appropr...
docs.google.com
Love worms, molecular genetics, and big questions? We’re hiring a postdoc to build a CRISPRa toolkit to identify new aging mechanisms in C. elegans. Email or DM me to find out more. Please share & repost!
Postdoctoral Research Associate, Biology
About the Opportunity Job Summary The Apfeld Lab at Northeastern University is seeking a postdoctoral researcher to investigate how genes work together to determine the maximum lifespan of the nematod...
northeastern.wd1.myworkdayjobs.com
The “BOBS” category in today’s puzzle seems slightly anti- #Celegans What about HERMAN, WATERSTON, or HERMAN?
That seems like such a shallow depiction of all of C. elegans’ behaviours and strengths. Clearly he never spent an hour watching some crawl around a plate. Oh well, who has time to educate all of the plebes.
Dr. Emily Arndt 🏳️⚧️@brachinus.bsky.social · last yr.Michael Eisen (who is at mbeisen dot bsky dot com) answered a tweet asking for people’s least favorite model organism with: “C. elegans. They wriggle forwards, they wriggle backwards, and sometimes they fuck”
Are you using Bluesky primarily as a source for links but are overwhelmed by the massive inflow of posts and doom? I wrote a small #Emacs package to fetch links from your #Bsky feed, sort them by frequency and time posted, and present them in an #orgmode buffer. github.com/rtrppl/hotsky
That’s a wrap on our first-ever Full Length 16S rRNA @pacbio.bsky.social Sequencing & Bioinformatics course! 🧪💻 From lab bench to species-level insight, participants processed their own data through QC, DADA2, taxonomic annotation & more, to create figures like this! 🧬👇
📝 New Bioconductor blog post on Outreachy internship experience by Kate Rasheed and Aleru Divine, mentored by the #bugsigdb team. Check it out here: blog.bioconductor.org/posts/2025-0... #Bioconductor #Bioinformatics #Outreachy #Internship #OpenSource #OpenScience
Outreachy December 2024 Interns with Bioconductor – Bioconductor community blog
Bioconductor participated in the Outreachy Internship program for the December 2024 to March 2025 cohort. Our interns share their experience working on their various projects and Bioconductor in…
blog.bioconductor.org