Excited to share our @natprot.nature.com paper on using RNA proximity labeling to map subcellular RNA transcriptomes. We’ve been working in this area for a while and wanted to create a resource paper to guide the uninitiated reader. rdcu.be/fblvI

APEX-seq maps transcriptome-wide subcellular RNA localization in living cells

Nature Protocols - This Protocol describes the transcriptome-wide labeling of RNAs in a particular subcellular compartment using proximity biotinylation by localized APEX2 enzyme and subsequent...

rdcu.be

Excited to speak at the Philly Pint of Science about our work on diet and inflammation -- always a fun event! 🔬🍻

Please join us for the Cold Spring Harbor Asia @cshlnews.bsky.social meeting on Bacterial Infection & Host Defense this May 11-15 in Suzhou, China! We have a fantastic lineup of speakers. Abstract deadline is March 6. Hope to see you there!

I'm excited to share that the Auditory Systems Gordon Research Seminar is accepting abstracts! This year's GRS will be July 18-19 in Easton, MA. The GRS is an amazing opportunity for trainees to share their work and network with other colleagues in the field. Apply here: www.grc.org/auditory-sys...

NHLBI has not funded a single new R01 in FY2026 which began almost 5 months ago

PAPER ALERT! I am excited to share that our study describing the molecular mechanism of caspase-4 activation has just been published in Immunity. www.cell.com/immunity/ful... I would like to thank all the co-authors for their valuable contributions. Well done guys! Link for short summary below👇

Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation

The cytosolic LPS sensor caspase-4 controls antibacterial immunity by inducing pyroptosis and cytokine secretion. Began et al. show how remodeling of LPS membranes by interferon-induced GTPase GBP1 pr...

cell.com

Online now: Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation

#WeekendRead! #ImmunometabolismPower! #InflammasomePower! Liu, Yin &co show @cp-cellchembiol that lactate downstream of aerobic glycolysis is used to directly lactylates NLRP3 increasing ASC recruitment and inflammasome activation, which exacerbates lethality in sepsis! www.cell.com/cell-chemica...

Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylation

Liu et al. reveal that lactate, an aerobic glycolysis product, promotes NLRP3 inflammasome activation and pyroptosis. NLRP3 is identified as a target of lactylation, and K24 and K565 have potential to...

cell.com

My nonprofit @your.neighborhoodscientist.org is looking for scientists to share their stories with us in 2026! Is your New Year's resolution to communicate & interface more with your community as a scientist? Send us a pitch at audrey@neighborhoodscientist.org ! 🧪🧠🇺🇸

Congratulations to my & @brodskyigorlab.bsky.social’s joint postdoc Suhas Bobba on receiving the @asm.org Infection & Immunity Poster Award for his work on innate immune control of intestinal Yersinia infection at the Midwinter Conference of Immunologists @midwinter-immun.bsky.social!

I had a wonderful time at Midwinter Immunology & was honored to receive the Ray Owen Poster Award after an awesome presentation by @sunnyshinlab.bsky.social! 2026 was my first time attending — definitely won’t be my last! Thank you to @brodskyigorlab.bsky.social & co. for an amazing meeting! 🙏

Dr. Sunny Shin@sunnyshinlab.bsky.social · 8mo ago

Congratulations to my postdoc @mikelhaggadone.bsky.social for receiving the @aai.org Ray Owen Poster Award at the Midwinter Conference of Immunologists @midwinter-immun.bsky.social for his work with Brian Goldspiel & @metabailism.bsky.social, which is now on bioRxiv! www.biorxiv.org/content/10.6...

Excited to share our new pre-print on the control of NLRP3 inflammasome assembly and ASC translation dynamics by environmental amino acids. A true team science effort: our phenomenal partners @mikelhaggadone.bsky.social & @sunnyshinlab.bsky.social working with Brian Goldspiel 🙏

Mikel Haggadone, PhD@mikelhaggadone.bsky.social · 9mo ago

I’m stoked to share my postdoc work with @sunnyshinlab.bsky.social, a collaborative effort with @metabailism.bsky.social & Brian Goldspiel, aided by many valued collaborators: Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly. Some big takeaways:

@biorxivpreprint.bsky.social Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly @briangoldspiel.bsky.social @mikelhaggadone.bsky.social @sunnyshinlab.bsky.social @pennmicro.bsky.social @metabailism.bsky.social www.biorxiv.org/content/10.6...

Congrats @sunnyshinlab.bsky.social and colleagues on this super cool and intriguing story on the role of dietary amino acids in regulating NLRP3 inflammasome activation by controlling translation of the ASC adapter! 🤯🙌🏼

Dr. Sunny Shin@sunnyshinlab.bsky.social · 9mo ago

Thrilled to share our new preprint showing that dietary amino acids license the NLRP3 inflammasome via mTOR-dependent mRNA translation! Congrats to co-1st authors @mikelhaggadone.bsky.social, Brian Goldspiel, co-senior author @metabailism.bsky.social & collaborators! www.biorxiv.org/content/10.6...

Congrats @mikelhaggadone.bsky.social on this beautiful work. So excited to see the preprint out!

Mikel Haggadone, PhD@mikelhaggadone.bsky.social · 9mo ago

I’m stoked to share my postdoc work with @sunnyshinlab.bsky.social, a collaborative effort with @metabailism.bsky.social & Brian Goldspiel, aided by many valued collaborators: Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly. Some big takeaways:

Thrilled to share our new preprint showing that dietary amino acids license the NLRP3 inflammasome via mTOR-dependent mRNA translation! Congrats to co-1st authors @mikelhaggadone.bsky.social, Brian Goldspiel, co-senior author @metabailism.bsky.social & collaborators! www.biorxiv.org/content/10.6...

Mikel Haggadone, PhD@mikelhaggadone.bsky.social · 9mo ago

I’m stoked to share my postdoc work with @sunnyshinlab.bsky.social, a collaborative effort with @metabailism.bsky.social & Brian Goldspiel, aided by many valued collaborators: Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly. Some big takeaways:

Why is obesity often associated with dysregulated, low-grade chronic inflammation? In our new paper in @science.org we show that obesity rewires nucleotide metabolism in immune cells, making inflammatory responses much easier to trigger. www.science.org/doi/10.1126/...

Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity

Obesity is a major disease risk factor due to obesity-associated hyperinflammation. We found that obesity induced Nod-like receptor pyrin domain–containing 3 (NLRP3) inflammasome hyperactivation and e...

science.org

I’m stoked to share my postdoc work with @sunnyshinlab.bsky.social, a collaborative effort with @metabailism.bsky.social & Brian Goldspiel, aided by many valued collaborators: Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly. Some big takeaways:

bioRxiv Immunology@biorxiv-immuno.bsky.social · 9mo ago

Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly https://www.biorxiv.org/content/10.64898/2026.01.16.699988v1

Powerful piece in STAT this morning from some NIH staff members who have resigned www.statnews.com/2026/01/10/n... 1/3

The NIH has lost its scientific integrity. So we left

“We can no longer lend our credibility to an organization that has lost its integrity,” write four scientists and administrators who recently resigned from the NIH.

statnews.com

Which amino acid is most required for T cell leukemia? Did you guess...histidine? excited to see this out, congrats to Komal and @herranzlab.bsky.social and coauthors! www.biorxiv.org/content/10.6...

A dietary pan-amino acid dropout screen in vivo reveals a critical role for histidine in T-ALL

Dietary interventions show therapeutic potential in cancer, but systematic comparisons are lacking. We performed a dietary pan-amino acid dropout screen in an orthotopic model of NOTCH1-driven T-cell ...

biorxiv.org

Happy to see the final piece of my PhD research out in the world: www.frontiersin.org/journals/imm... Here, we provide more evidence that the homeostatic biology of alveolar macrophages is highly sensitive to glucose metabolism, this time in the context of non-small cell lung cancer. 🫁 🧫

Frontiers | Glycolytic reprogramming of resident alveolar macrophages contributes to reduced SOCS3 secretion in non-small cell lung cancer

Alveolar macrophages (AMs), the resident immune cells of the lung, play a critical role in maintaining pulmonary homeostasis, in part through the secretion o...

frontiersin.org

Funding for science is significantly challenged right now and this is particularly devastating to our young scientists. If you have the means to support science on this Giving Tuesday, our trainees would be so grateful! maizeraise.umich.edu/schools/Univ...

Microbiology and Immunology Endowed Graduate Education

Join me and make a gift to A Crowdfunding Default

maizeraise.umich.edu

This week’s neighborhood scientist is Charity Robbins! Check out the link below to read Charity’s rules on how to build the perfect scientist (yes, really!!) neighborhoodscientist.org/posts/2025/l...

Lessons from an Undergraduate Researcher on How to Build the Perfect Scientist (Yes, Really!) – Your Neighborhood Scientist

science news for everyone

neighborhoodscientist.org

💥 #ImmunometabolismPower! Excited to have this officially out @cp-immunity.bsky.social 💥 We show that pathogens induce the host to produce oxidized lipids which rewire the #metabolism of #macrophages, causing #epigenetic modifications which dampen anti-inflammatory IL-10, exacerbating #inflammation!

Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections

Phagocytes initiate immunity to invading microorganisms by detecting pathogen-associated molecular patterns via pattern recognition receptors. Pathoge…

sciencedirect.com

If you want to support the work we do, you can donate to my nonprofit @your.neighborhoodscientist.org here: neighborhoodscientist.org

Your Neighborhood Scientist

cultivating community-based conversations around science, science policy, and scientists

neighborhoodscientist.org

Excited to be featured in today’s @nature.com article about scientists standing up to Trump. I’ve never been one to sit on the sidelines, especially when something I believe so deeply in—science funding that saves lives—is under attack. Read more here: www.nature.com/articles/d41...

Scientists take on Trump: these researchers are fighting back

Through lawsuits, grant tracking, whistle-blowing and more, resistance to the US war on science is growing.

nature.com

Brendan Maher@bmaher.bsky.social · last yr.

And we talk about how @audreydrotos.bsky.social @bnwolford.bsky.social and countless others are organizing to spread the word about the value of science that is being scaled back, and the impacts of that missing investment. 🧪🧵5/6

Very stoked for and proud of my dear grad school pal, @jazib.bsky.social. No one pushes themselves harder than this guy! 💪 A beautiful body of work!

Jazib Uddin@jazib.bsky.social · last yr.

Very excited to share the latest work from the Artis lab! Now out in @natimmunol.nature.com Your gut’s neurons aren’t just for digestion; they help heal it too! nature.com/articles/s41...

Very excited to share the latest work from the Artis lab! Now out in @natimmunol.nature.com Your gut’s neurons aren’t just for digestion; they help heal it too! nature.com/articles/s41...

I’m very honored to receive the inaugural Penn Postdoctoral Association Mentorship Award for my work with the Class of 2027 PennFERBS undergraduate scholars. My students mean the absolute world and continue to amaze me with their drive, passion, and eagerness to grow as leaders in STEM. 🙏

🚨 AAI is proud to announce the launch of the AAI RESTORE Grants Program, an $8M emergency funding initiative to support scientists whose immunology-focused federal research grants were abruptly terminated or frozen in 2025. 🔗 ow.ly/rwMU50Wy3Mp #AAIRESTORE