I want to try something again at #ASHG26: I'll block off some time on Weds/Th/Friday afternoons to meet with trainees who would be interested to chat on any topic. I have done this the last 2 years and it was great to meet a whole bunch of new people, from many countries, at all career stages!

Our next Variant Effects Seminar is tomorrow – October 6, when @marianomartin.bsky.social and Seulki Kwon will present their research. Discover this month's speakers and get joining instructions: www.varianteffect.org/seminar-seri... #DeepMutationalScanning #AtlasOfVariantEffects

From a discussion of updating a department website...

Come be my colleague!! 🎉 We’re hiring an Assistant Professor in Developmental Biology at UCSD! If you’re doing exciting work in development or regeneration, come join us!! Please spread the word and apply! apol-recruit.ucsd.edu/JPF04591

Assistant Professor of Developmental Biology

University of California, San Diego is hiring. Apply now!

apol-recruit.ucsd.edu

Please spread the news - the Department of Neurobiology at UCLA is hiring. This is an open rank search for all and any amazing neuroscientists! Please apply here by Nov 15th, first review end of October : recruit.apo.ucla.edu/JPF11296

Open-rank tenure-track faculty position

University of California, Los Angeles is hiring. Apply now!

recruit.apo.ucla.edu

The Baylor College of Medicine Conference on Structural Variants and DNA Repeats is back, and this year it has a new home! Join us in person in Houston November 19th–20th. Or join online. Virtual registration is FREE! ErwinLab.org/svar-conference

Yet another #zebrafish genome update: We just updated our ZebrafishGenomics public datahub for the UCSC browser (available all the way at the bottom here: genome.ucsc.edu/cgi-bin/hgHu...). We added several useful tracks including:

📣NAR is recruiting a new Executive Editor!📣Seeking an established researcher with expertise in RNA biology and translation mechanisms to help shape the journal's scientific direction, oversee peer review, and support its growth. Apply by 30 Sept 2026: academic.oup.com/nar/pages/ex...

‘Inhabiting the data’ is how CalTech Professor Ellen Rothenberg describes her process for coming up with a new idea, in the very first episode of the Night Science Podcast. (@nightsciencepod.bsky.social)

Missed Abbye McEwan's excellent introduction to MAVE technology? It's now available on YouTube: www.youtube.com/watch?v=FeUp... Learn more about how to use MAVE data to inform clinical variant classification, and discover how these datasets may help resolve variants of uncertain significance.

VSN presents Beyond the VUS Using MAVE Data to Inform Clinical Variant Classification

YouTube video by Variant Scientists Network

youtube.com

link.springer.com/article/10.1...

Pan-cell type continuous chromatin state annotation of all epigenomes from the International Human Epigenome Consortium - Genome Biology

Background The International Human Epigenome Consortium has generated thousands of datasets profiling transcription factor binding, histone modification, and DNA accessibility. Existing segmentation a...

link.springer.com

www.nobelprize.org/prizes/econo...

Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel 2025

The Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel 2025 was awarded "for having explained innovation-driven economic growth" with one half to Joel Mokyr "for having identified ...

nobelprize.org

Asteroid Threat xkcd.com/3265/

Foundational! "The scientist doing basic research may not be at all interested in the practical applications of his work, yet the further progress of industrial development would eventually stagnate if basic scientific research were long neglected." From Science: The Endless Frontier, Bush, 1945

Princess Vimentin PhD | Cancer Biologist@princess-vimentin.bsky.social · 4mo ago

Nothing is more annoying than seeing a badge telling you there's one unread message or task in an app, then going through every corner of the app and not finding it.

Don't miss Abbye McEwen's deep dive into interpretation of variants of unknown significance (VUS) - happening today (12.00 pm ET / 9.00 am PT / 5.00 pm BST). Join here: bit.ly/3Seq0LL #DeepMutationalScanning #VariantScientistNetwork #AtlasOfVariantEffects

This Wednesday, are you ready to go beyond the VUS and learn more about using multiplexed assays of variant effects (MAVEs) to inform clinical variant classification? It's free to sign up: bit.ly/3Seq0LL #DeepMutationalScanning #VariantScientistNetwork #VUS #MAVE #AtlasOfVariantEffects

Bioconductor 3.23 is released! Thanks to the core team for all the hard work that goes into a release, and to the package reviewers. The lab has a bunch of updates in here that I'll post in 🧵 over the next few days:

Bioconductor@bioconductor.bsky.social · 6mo ago

🚀 We’re excited to share the release of Bioconductor 3.23, featuring: ✅2418 software packages (94 new) ✅437 experiment data packages (5 new) ✅928 annotation packages ✅8 books (2 new) ✅28 workflows 🔗 Please see the full release announcement here: bioconductor.org/news/bioc_3_...

There's a strange myth about science: that theory comes first, and that data cannot show anything new. But anyone who's ever done science knows the truth that there's a long conversation between data & hypotheses. Back & forth.. until the discovery. And if you think about it, it has to be this way!

Congratulations to NAS President-Elect @neilshubin.bsky.social on winning @sse-evolution.bsky.social's Stephen Jay Gould Prize! The award honors individuals who have advanced public understanding of evolutionary science in the spirit of #NASmember Stephen Gould. evolutionsociety.org/index.php?mo...

Professors: come get trained by us in how to teach the Night Science Workshop on the creative scientific process to your students who are thirsty for this material! Our Train-the-Trainer 1day program in NYC April 24 is in partnership with the NY Academy of Sciences! night-science.org/train-the-tr...

A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...

An integrated view of the structure and function of the human 4D nucleome - Nature

The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...

nature.com

🎉 New in #GENETICS: Functional Genomics & Systems Biology section! Highlighting cutting-edge studies on molecular networks, systems-level insights, and innovative methods. Read more: buff.ly/wWVZdrS%F0%9...

Announcing the new “Functional Genomics and Systems Biology” section in GENETICS

The GSA Journals are introducing Functional Genomics and Systems Biology, a new section led by Brenda Andrews and Marian Walhout that highlights systems-level studies of genetic networks and pathways.

buff.ly

Possible new treatment for Lyme disease: pubmed.ncbi.nlm.nih.gov/40267215/

A high-resolution screen identifies a preexisting beta-lactam that specifically treats Lyme disease in mice - PubMed

Lyme disease, caused by <i>Borrelia burgdorferi</i> in the United States, is an escalating human health problem that can cause severe disease if not properly treated. Doxycycline is the primary treatm...

pubmed.ncbi.nlm.nih.gov

Possible mechanism for chronic illness following Lyme disease pubmed.ncbi.nlm.nih.gov/40267217/

The peptidoglycan of Borrelia burgdorferi can persist in discrete tissues and cause systemic responses consistent with chronic illness - PubMed

Persistent symptoms after an acute infection is an emerging public health concern, but the pathobiology of such conditions is not well understood. One possible scenario involves the persistence of lin...

pubmed.ncbi.nlm.nih.gov

The 80-year recipe stoking America’s Prosperity: 1) Free-market capital investments in brilliant ideas… 2) enabled by Engineering Innovations… 3) based on Science Research in Universities… 4) funded by Grants from the US Government. It’s time more people understood this.