The human #heart is a biological powerhouse that has the capacity to beat billions of times. But what prompts that very first #heartbeat? And how can #ComputationalArt help us to unravel the mystery? @clcortex.bsky.social explains in our brand new video. 🎥 https://bit.ly/HeartsAnew  1/2

We are happy to share our new bioRxiv pre-print on A-P axis patterning. A great collaboration with Felix Zhou (UT Southwestern) & the Yeomans group (Physics, Oxford) www.biorxiv.org/content/10.6...

E15.5 Mouse Heart stained for CD31 (Red), Smooth-Muscle MHC (Cyan) and DAPI (White). Imaged with Zeiss Lightsheet Z.1 @ox.ac.uk @idrm.ox.ac.uk @oxforddpag.bsky.social @srinivas-lab.bsky.social @bsdb.bsky.social @zeiss-microscopy.bsky.social

Institute of Developmental & Regenerative Medicine@idrm.ox.ac.uk · 9mo ago

Rise of the Arteries — a lightsheet image capturing the intricate vascular network of a developing mouse heart. By visualising endothelial and smooth muscle cells in 3D, researchers at IDRM reveal the beauty of coronary vessel formation. 📷 Credit: Konstantinos Miti & Polen Bareke

Our calcium paper is out in PLOS Biology! Check it out! #Calcium #Embryo #Development

PLOS Biology@plosbiology.org · 10mo ago

During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. @m-stower.bsky.social @srinivas-lab.bsky.social &co reveal the role of Ca2+ dynamics in this, showing that inhibition of #calcium transients causes DVE arrest @plosbiology.org 🧪 plos.io/4nHWxF4

Very happy to share I've written a review on placental vascular formation in mice and humans, now published in @dev-journal.bsky.social. journals.biologists.com/dev/article/... @idrm.ox.ac.uk Funded by the @thebhf.bsky.social

Feto-placental blood vessel development

Summary: This Review contains an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field.

journals.biologists.com

@mitisbio.bsky.social from @ox.ac.uk spoke about the dynamics of calcium oscillations and their role during peri-gastrulation in the mouse embryo

We are happy to announce student and postdoc speakers. Thanks to all who submitted an abstract! #yen2025

This #FluorescenceFriday feels like fluorescence xmas! Thanks for all your submissions to the YEN Image Competition. Excited to see so many spectacular visualisations of embryonic development and stem cell biology! #YEN2025

Very excited to share our work on calcium dynamics during early mouse development at #biologists100. Stop by Poster 182 to say hi and learn more! @biologists.bsky.social @the-node.bsky.social @focalplane.bsky.social @bsdb.bsky.social @srinivas-lab.bsky.social

Happy Valentine's day from the Simões group❣️ @simoesfilipa.bsky.social #spreadthelove#mendingbrokenhearts#cardiacorganoids Image taken by @mitisbio.bsky.social

Happy to share our latest review by @shifaant.bsky.social with @cwhanna.bsky.social. A detailed look at extraembryonic tissues – the 'other half' of the conceptus. www.nature.com/articles/s41... @natrevmcb.bsky.social

Origin, fate and function of extraembryonic tissues during mammalian development - Nature Reviews Molecular Cell Biology

During mammalian embryogenesis, extraembryonic tissues are required for the patterning and morphogenesis of the embryo. This Review discusses how signalling networks and epigenetic modifications regul...

nature.com

Truly excited about this new endeavour- co-leading the Oxford Organoid Hub with @rdmoxford.bsky.social colleague Chris Toepfer! Big thanks to @oxforddpag.bsky.social & BHF CRE for believing in our vision! Pretty pics by force-of-nature DPhil students Selin Tüzüner & @mitisbio.bsky.social @ox.ac.uk

OxfordDPAG@oxforddpag.bsky.social · 2y ago

Read all about the Oxford Organoid Hub www.dpag.ox.ac.uk/news/the-oxf... The image shows a ventricular spheroid derived from induced pluripotent stem cell derived cardiomyocytes. Credit Cheryl Tan.

Happy to have the Srinivas lab on Bluesky! Even our embryos are starting to feel a little festive in the Srinivas lab! We are excited to share our new bioRχiv pre-print – investigating the role of calcium in the early embryo www.biorxiv.org/content/10.1...

Calcium signalling is required for anterior patterning in the mouse embryo https://www.biorxiv.org/content/10.1101/2024.11.14.623160v1

Calcium signalling is required for anterior patterning in the mouse embryo https://www.biorxiv.org/content/10.1101/2024.11.14.623160v1

Anterior-Posterior axis formation in the mouse embryo requires the active migration of the DVE cell

biorxiv.org