New preprint alert!!! Super proud to finally share an authentic 'tour-de-force' from the amazing PhD students Shivani Gunnan @shivanigunnan.bsky.social, Max Kotz and Lucas Ribas, in collaboration with @friedrich-group.bsky.social 👇a small thread www.biorxiv.org/content/10.6...

Developmental growth rates adapt to enable self-correction of organ morphology after injury.

Proportional organ growth requires tissue-level control of cell behavior. Yet the cues that adapt growth rates, especially after organ injury, remain unclear. Here, we uncover that developing organs a...

biorxiv.org

Thrilled to post thread re: new single-cell lineage of mouse embryo reconstructed w/ DNA Typewriter. One animal, zygote to late organogenesis (E13.5). Tree has 1,340,794 transcriptionally profiled, annotated tips (cells), 1,142,588 dated internal nodes, rooted at zygote 1/n

Super cool mechanism tbh

Barbara Marte@barbmarte.bsky.social · 7d ago

new out in Nature www.nature.com/articles/s41...

"One is you have to be very curious about something. No. 2, you have to have an unfailing urge to address the question you have. No. 3, I think it helps to try to combine knowledge in at least two different fields where people don’t necessarily interact.” www.nytimes.com/2026/07/21/s...

Susumu Tonegawa Dies at 86; Nobel Laureate Showed How Antibodies Fight Infection

The first Japanese scientist to win the Nobel Prize in Physiology or Medicine, he went on to discover how memories are stored, advancing understanding of how the brain works.

nytimes.com

Amen!! to all of it. Only to add that as computational biologist, I don't get paid to code. I get paid to turn biological questions into computational experiments, to interpret numbers and tons of data to give biological insights. Learning to write, code or text, is learning to think.

“A Penn professor thought she’d sell 1000 copies of her ‘Odyssey’ translation. She sold a million this year alone, thanks to Christopher Nolan.” “West Philly's Emily Wilson, who penned a highly acclaimed translation of the epic poem in 2017, is having a big summer.”

A Penn professor thought she’d sell 1000 copies of her ‘Odyssey’ translation. She sold a million this year alone, thanks to Christopher Nolan.

West Philly's Emily Wilson, who penned a highly acclaimed translation of the epic poem in 2017, is having a big summer.

share.inquirer.com

Creativity is ultimately rooted in the individual –Ruth Lehmann, Director of the Whitehead Institute, MIT

4D Nucleome special issue of Science, featuring our paper "Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor", led by Zoe Grant in my lab and Zhuzhen Kuang in Katie Pollard's lab @gladstoneinst.bsky.social www.science.org/toc/science/...

A true giant of #DevBiol! For you youngsters who might not know, among her decades of fantastic discoveries was this thing she found in 1981 that she called "Embryonic Stem Cells." I think some people still study them. Thanks to Alex for writing this lovely piece!

Developmental Biology@devbiol.bsky.social · 2w ago

#DBfeature A tribute to Gail R Martin, mouse geneticist and mentor extraordinaire (April 12, 1944 - Feb 9, 2026) By Alexandra Joyner doi.org/10.1016/j.ydbio.2026.05.007

This... I am here for this.

Dom Ervolina@dominicervolina.com · 2w ago

Nico Williams Jr. presenting his World Cup medal to his mother She crossed the Sahara while pregnant with his older brother, Iñaki, to make a better life for her children

Often people have something that makes them their skin tingle. I'm a believer in that skin tingling. –Sarah Teichmann, on choosing a project (from the Night Science Podcast, episode 5) @teichlab.bsky.social

How does an embryo generate the right cells in the right place? Delighted to share our latest findings on how neural crest cells acquire vagal or trunk identities Spoiler alert: The timing & combination of CDXs preconfigures cell identity & distinct HOX states www.biorxiv.org/content/10.6...

Temporally distinct CDX programmes preconfigure vagal and trunk neural crest

Neural crest cells (NCCs) are progenitor cells vital in establishing the head, heart, gut and peripheral nervous system of vertebrate embryos. Disruptions to NCC development underlie neurocristopathie...

biorxiv.org

My first search engine.

Maybe creativity is just how big a bag of tricks you have; how many different tricks you've seen, applied in different contexts. And perhaps some people have a little bit more skill remembering all those tricks or applying them in different situations. - Arjun Raj, @arjunraj.bsky.social

Our AI-guided design of RNA-guided nucleases is now out in @science.org 💻🧬 We used structure and evolutionary data to generate minimal, active and divergent gene editors! www.science.org/doi/10.1126/... Congrats to @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social & team!

Structure and evolution-guided design of minimal RNA-guided nucleases

The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic ...

science.org

I had the chance to highlight some amazing #DevBio from @gcharras.bsky.social and @herveturlier.bsky.social for @natcellbio.nature.com this month! Check out my Research Highlight www.nature.com/articles/s41... and the original article in @cp-devcell.bsky.social www.sciencedirect.com/science/arti...

Excited to share our latest study identifying Scube2 as a novel regulator of coronary vessel formation and heart regeneration, promoting regenerative revascularization through PDGF signaling and EC-mural cell interactions published in ATVB @americanheart.bsky.social ahajournals.org/doi/10.1161/AT…

Just approved an order for standard lab consumables. Prices have nearly doubled since starting the lab. Meanwhile, the bar for publishing keeps rising, requiring ever more costly experiments, while grant budgets barely changed. Hard to see how this is a sustainable trajectory for academic research.

'I would not be talking about the fish that my team discovered if we didn’t have long-term funding that allowed me to fail and learn from failures. The only way I was able to learn from failures was to have long-horizon funding, when I wasn’t being measured from year to year'

“I Am an Unabashed Optimist About the Long-Term Future of Science.”

The new president of the National Academy of Sciences talks about learning to see as a scientist and communicating science in a noisy information landscape.

issues.org

"The university model may have to change." @neilshubin.bsky.social Listen to your inner fish.

The National Academies of Sciences, Engineering and Medicine@nationalacademies.org · last mo.

Science is entering a new era — one filled with both extraordinary opportunities and significant challenges. As he begins his National Academy of Sciences presidency, Neil Shubin reflects on this pivotal moment in a new interview with Issues in Science and Technology: https://ow.ly/NG8X50ZkLfg

The ever amazing Steve Henikoff! @fredhutch.org @basicsci.fredhutch.org

HHMI@hhmi-science.bsky.social · 4w ago

Discoveries can hide in plain sight. #HHMIInvestigator Steven Henikoff's lab found a surprise when revisiting their old data: a region of ribosomal DNA producing microRNAs that can be associated with cancer, revealing a new role for part of the genome overlooked for decades: bit.ly/3RQwTmy.

A hero’s welcome for the Cabo Verde team arriving home ❤️

Wow who’d have thunk it, vaccines work 🤔 Great news to celebrate.

Paying peer reviewers Interview with @danielgorelick.bsky.social about @biologyopen.bsky.social Fast & Fair trial in which peer reviewers were paid £220/review Spoiler: it works - fast, high quality reviews www.nature.com/articles/d41...

Why paying peer reviewers works, according to a journal’s editor-in-chief

A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.

nature.com

This is the other paper from our group that landed on BioRxiv yesterday, three in a week 😍

Alberto Docampo Seara@albertodseara.bsky.social · last mo.

Congratulations to Dr. Markus Westphal and Dr. Rachel Branch from @beckergroup.bsky.social on this cool preprint! They show that spinal cord injury induces a stem-like progenitor state, and that these cells actively signal to their environment!! Find more on @biorxivpreprint.bsky.social

New in @dev-journal.bsky.social: how tissue shape tells cells what to become Using human stem-cell neuruloids, we show how that physical boundaries encode positional information that drives cell fate patterning in a model of trunk formation A thread 🧵 journals.biologists.com/dev/article/...

Boundary constraints can determine pattern emergence

Summary: A reaction-diffusion mechanism recapitulates pattern emergence in an in vitro model of neuromesodermal progenitors under a variety of boundary and geometrical perturbations.

journals.biologists.com

😮 @danielgorelick.bsky.social @biologyopen.bsky.social www.nature.com/articles/d41...

Why paying peer reviewers works, according to a journal’s editor-in-chief

A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.

nature.com

It is out 😍 check it out!! Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning. @cschwayer.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social www.cell.com/cell/fulltex...

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

cell.com

1/ 🧬🔬 How does one cell become an entire animal? We can now film it in 3D 🐟, but turning those movies into accurate cell tracks is brutally hard. Enter our new #Kaggle challenge: $60K prize pool, to help crack 3D+time cell tracking at scale! 🧵👇 www.kaggle.com/competitions... @biohub.org

Where Igor Ademeyko @adameykolab.bsky.social walks us through a beautiful scenario of what the hell neural crest cells are, co-option, and the camouflage hypothesis. With special mention of Rohon-Beard neurons! 🧪🐟

Co-option and innovation in neural crest evolution

Neural crest evolution reassembled ancient programs in pigment cell lineage, resulting in vertebrate innovations.

science.org