Delighted to share the launch of the Cambridge-led, £50m MRC Centre of Research Excellence in Mitochondrial Genome Therapeutics (CoRE-MitoGT). Over 14 years, we will unite international expertise to understand mtDNA disease & develop therapies targeting its root causes. www.ukri.org/news/mrc-fun...

MRC funds world-class research into fatal genetic diseases

The Medical Research Council (MRC) has invested £50 million into the study of mitochondrial diseases to improve treatments.

ukri.org

Please check out our bioRxiv preprint 🧬 We present MitoBEAP, the R package for analysing mito. base-editing experiments, enabling assessment of editing efficiency and off-targets from NGS data. A huge congratulations to @lindseyvanhaute.bsky.social and the team 🎉 www.biorxiv.org/content/10.6...

Development of the Mitochondrial Base Editor Analysis Package (MitoBEAP)

For many years, the genetic manipulation of mitochondrial DNA was largely hampered by inefficient delivery of nucleic acids to mitochondria. However, the development of mitoCBEs, such as mitochondrial...

biorxiv.org

We're hiring a Postdoctoral Research Associate at the MRC Mitochondrial Biology Unit @mrc-mbu.bsky.social Cambridge Join our ARIA Precision Mitochondria project with Bitrobius Genetics to develop novel technologies for mitochondrial DNA delivery and genome engineering www.cam.ac.uk/jobs/researc...

We are pleased to share a new review published in Cell Reports Medicine @cellpress.bsky.social: “Emerging therapeutic strategies for mitochondrial DNA-related diseases” Full article: doi.org/10.1016/j.xc... #Mitochondria #mtDNA #GeneTherapy #GenomeEditing #RareDiseases #TranslationalMedicine

Great to bring together 70+ researchers & partners at the LifeArc Centre for Rare Mitochondrial Diseases Annual Meeting in Cambridge last week! From scientific updates and flash talks to patient voice discussions it was a day full of insight and collaboration!

Looking forward to seeing you soon at Queen Square Advances in Mitochondrial Medicine 2026! We hope you'll join us for the day, plus the networking reception after (drinks and snacks provided). UCL/UCLH staff & students - contact us via email for your free registration code: bit.ly/QSmitomed2026

Queen Square Advances in Mitochondrial Medicine 2026

The London Mitochondrial Centre is hosting a one-day symposium.

bit.ly

London Mitochondrial Centre@londonmito.bsky.social · 4mo ago

Just over a month to go! Register now to secure your place 👉 bit.ly/QSmitomed2026

Clinicians and researchers with an interest in #mitochondrial disease: Queen Square Advances in Mitochondrial Medicine (5 May 2026) is a CPD-approved course covering pre-clinical & translational research, and the latest updates in NHS diagnostic testing. Registration: www.ucl.ac.uk/brain-scienc...

Queen Square Advances in Mitochondrial Medicine 2026

The London Mitochondrial Centre is hosting a one-day symposium.

ucl.ac.uk

Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier. CRISPR-based tools can’t easily access the DNA in these organelles, but researchers are finding other ways in www.nature.com/articles/d41...

Faulty mitochondria cause deadly diseases: fixing them is about to get a lot easier

CRISPR-based tools can’t easily access the DNA in these organelles, but researchers are finding other ways in.

nature.com

@mitogene.bsky.social we are looking forward to your presentation at #MitoCellFate in Malta! Please share this with your followers to let them know the Earlybird & Talk submission deadline is fast approaching - Monday 10 November. Register & Submit here: bit.ly/46TS4Ii

It’s here – World Mitochondrial Disease Week! 💚 We’re proud to collaborate with other mito charities across the UK to put mito on the map – let's spread the word together! 👉 See how you can get involved: 🔗 thelilyfoundation.org.uk/charity/get-involved/world-mitochondrial-disease-week

Don't forget to register and submit your abstract for our #MitoCellFate conference in Malta next year ☀️ 📢Check out our wonderful speaker line-up so far! 📅Early-bird & talk deadline: 10 Nov 2025 bit.ly/46xBYVt #FusionStemCells #FusionAgingResearch

Massive congratulations to @lucialugut.bsky.social on receiving the prestigious 2025 CSAR Award! 🎉 Lucia's groundbreaking work in modeling and correcting mtDNA mutations paves the way for innovative future therapies for mitochondrial diseases. @mrc-mbu.bsky.social www.csar.org.uk/student-awar...

The first-ever conference dedicated entirely to mitochondrial DNA just wrapped up in Nashville! From mutation mechanisms to repair strategies and cutting-edge editing techniques, it was a landmark event. See the full recap 👇 mitoworld.org/mechanisms-o...

Mechanisms of Mitochondrial DNA Mutation and Repair - MitoWorld

If our website is MitoWorld, the Mechanisms of Mitochondrial DNA Mutation and Repair conference was the introductory gathering of what could be called “mtDNA World.” The organizers, Patrick Chinnery (...

mitoworld.org

🎙️ Focus Speakers – Michal Minczuk @mitogene.bsky.social 👀 Curious to know who will be speaking at #euromit2026 ? ✨ Today, we’re introducing Michal Minczuk who will be taking the stage at the congress. #euromit2026 #mitochondria #angers @univangers.bsky.social @ua-recherche.bsky.social

Coverage of this important work led by @daniellahock.bsky.social and @dstroudlab.bsky.social who support our @lifearc.bsky.social research to replicate this @medicalsciencesncl.bsky.social @neygenomics.bsky.social @mitocamb.bsky.social @londonmito.bsky.social @lilyfoundation.bsky.social

The Guardian@theguardian.com · last yr.

Blood test developed that could speed up diagnosis of rare diseases in babies

Last chance to join us for the Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee @faseborg.bsky.social

FASEB@faseborg.bsky.social · last yr.

Last call for genetics scientists to save $150 at #MDNASRC 2025 with a can't-miss keynote presentation from Thomas Langer from @mpiage.bsky.social ... Save your seat by May 12: buff.ly/A12895w

🚨 Join us for the @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

Hello fellow mitochondriacs! Are you passionate about mtDNA? We now offer a 2-year postdoc opportunity for studies of mtDNA instability and its signaling. Apply by May 18th to join our international team in exotic Umeå. Please share! www.umu.se/en/work-with...

Postdoctoral fellowship (2 years) to study mitochondrial DNA stability

umu.se

Yesterday we were proud to join the launch of the LifeArc Centre for Rare Mitochondrial Diseases - a major step forward in mito research We led a workshop on making complex science clear – because involving patients is key to success #mitochondrialdisease #mitoresearch #patientvoice #raredisease

Very full schedule at our #IMGCglasgow workshop last week, delivered by MitoCluster team @robpitceathly.bsky.social, Carlo Viscomi, @mitogene.bsky.social, and @jim-ca.bsky.social. A pleasure to attend, thanks for the invite @mrcmousenetwork.bsky.social & IMGS! 🧬 #mitochondria #MouseModels #ECR

🚨 Join us for the @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

Clinically translatable mitochondrial #GeneTherapy in muscle using tandem mtZFN architecture. By P. Nash, @mitogene.bsky.social & colleagues @mrc-mbu.bsky.social 🗞️ doi.org/10.1038/s443... Read also related N&V by A. Ghifari & M. Ott 👉 doi.org/10.1038/s443...

Great opportunity!

Cambridge Clinical Mitochondrial Research Group@mitocamb.bsky.social · last yr.

2x CRA posts extended until end of April. So you have another chance to work with #mito disease patients as part of the @lifearc.bsky.social centre for #rare #mito diseases! See links below to apply! @eastgenomics.bsky.social @camneuro.bsky.social @cuhnhs.bsky.social

Huge congrats to Pavel Nash on publishing his PhD work! 🎉 We showcase a safer mtDNA gene therapy using a novel mtZFN architecture compatible with a single AAV. Thanks to the entire team! @mrc-mbu.bsky.social @mbu-postdocs.bsky.social #MitochondrialDisease #mtDNA www.embopress.org/doi/full/10....

Clinically translatable mitochondrial gene therapy in muscle using tandem mtZFN architecture | EMBO Molecular Medicine

imageimageEfficient mitochondrial gene therapy is achieved with a novel tandem zinc finger nuclease (mtZFN) architecture delivered via adeno-associated viral (AAV) vectors, significantly reducing mutation loads in muscle tissue and rescuing ...

embopress.org

Exciting news from Pretzel Therapeutics! We’ve launched a Phase 1 trial for our POLG activator—PX578—targeting rare mitochondrial syndromes with potential for Parkinson’s & Alzheimer’s diseases. Congratulations to the entire team—proud to be part of this journey! www.pretzeltx.com/pretzel-ther...

Pretzel Therapeutics Initiates Phase 1 Clinical Study Evaluating PX578, Lead Therapeutic in its Bioenergetics Restoration Franchise » Pretzel Therapeutics

First-in-class approach to targeting mitochondrial DNA polymerase (POLG) with disease modifying potential across mitochondrial DNA depletion syndromes

pretzeltx.com

We are hiring #bioinformaticians. One post to work on the new @lifearc.bsky.social centre for rare #mitochondrial diseases, and one is a joint project @mrc-mbu.bsky.social with Prof Patrick Chinnery & @mitogene.bsky.social Apply here: www.jobs.cam.ac.uk/job/50861/ www.jobs.cam.ac.uk/job/50860/

Really interesting read from #Beacon for RD about their involvement in the @lifearc.bsky.social centres for #raredisease Read it here: www.rarebeacon.org/blog/beacons... @lilyfoundation.bsky.social @robpitceathly.bsky.social @taylorlabncl.bsky.social @ritahorvath.bsky.social @mrc-mbu.bsky.social

Beacon's role in the LifeArc Translational Centres for Rare Disease - Beacon for rare diseases

This week's blog is written by our CEO, Rick Thompson. He discusses our role in the new LifeArc Translational Centres for Rare Disease.

rarebeacon.org

Exciting News: Learn about the Speakers of Euromit 2026! We are happy to announce the amazing speakers for Euromit 2026, the leading congress on mitochondrial pathology.🌍✨ 📢 See the full list ! 👇 #euromit2026 #mitochondria #science #innovation #angers

Looking forward to #IMGC2025 Glasgow next month! MitoCluster will be delivering an #ECR Workshop on Mouse Models of #Mitochondrial DNA Disease, featuring cluster lead @robpitceathly.bsky.social and investigators Carlo Viscomi, @jim-ca.bsky.social, and @mitogene.bsky.social🐁

MRC National Mouse Genetics Network@mrcmousenetwork.bsky.social · last yr.

The programme is now finalised, and the abstracts are on the IMGS website. Looking forward to seeing people in Glasgow and sharing some great science! hashtag#MouseGenetics hashtag#PreclinicalScience hashtag#PreclinicalResearch hashtag#MammalianGenetics www.imgs.org/2025-38th-im...

🌍Euromit 2026 is coming to Angers!🌍 ✨The international congress dedicated to mitochondrial research, will take place in France, at the Centre des Congrès of Angers. from May 31 to June 4, 2026! ✨ 📢 Stay informed by following this page and get ready for an exceptional scientific experience! 🚀🔬