Should researchers avoid translational research in animals in favor of human or AI models? www.nature.com/articles/s41...

A roadmap to competitive preclinical packages - Nature Medicine

Should researchers avoid translational research in animals in favor of human or AI models? We argue that this debate should focus not on comparing species but instead on how experimental systems can b...

nature.com

Monthly median Received to Accepted time (days) at Nature Genetics

Postdoc positions now open! We’re moving to Dept of Neurosurgery, U of Colorado Anschutz Medical Campus and have open positions to study brain tumor heterogeneity! If you’re passionate about beating GBM and have experience in related field, this may be for you: cu.taleo.net/careersectio...

Happy to share scHiCAR, an ultra-high throughout (millions of cells), low cost (5 cents/cell including NGS), and trimodal platform for integrated single-cell level analysis of mRNA, open chromatin, and 5-kb resolution looping with ground-truth data the same individual cell.

Nature Biotechnology@natbiotech.nature.com · 6mo ago

Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR - @yaruidiao.bsky.social @dukehealth.bsky.social go.nature.com/4rZqimf

Congratulations Jamie

Johns Hopkins University@jhu.edu · 7mo ago

Professor Jamie Spangler has been awarded the 2025 President’s Frontier Award for her groundbreaking work in molecular immunoengineering. Her pioneering research is shaping the future of therapies for cancer, autoimmune diseases, and more. https://bit.ly/4pMVsfo

I’m reading George Saunders “A swim in a pond in the rain”, which includes lessons from his writing course (he analyzes short stories from Russian masters like Chekhov and Turgenev). As always, I find everything relevant also to science (how to write or judge an article in this case) For example👇

And here is your accompanying editorial: Leveraging Single-Cell Profiling in Early-Phase Trials to Guide Rational Therapy Development url: academic.oup.com/neuro-oncolo...

Leveraging Single-Cell Profiling in Early-Phase Trials to Guide Rational Therapy Development

Julia Louw, Jodie Jepson, Anna M Corcoran, Mustafa Khasraw; Leveraging Single-Cell Profiling in Early-Phase Trials to Guide Rational Therapy Development, N

academic.oup.com

Shwetal Mehta@shwetalm.bsky.social · 9mo ago

Very excited to have this collaborative work on evaluating PK/PD and single-cell responses for Ribociclib+Everolimus in #rGBM published. It was such a great experience working with @kevin-johnson.bsky.social and @roelverhaak.bsky.social. @ivycenter.bsky.social @anchitien.bsky.social

Darwin's regrets: "If I had to live my life again I would have made a rule to read some poetry and listen to some music at least once every week.. The loss of these tastes is a loss of happiness, and may possibly be injurious to the intellect and more probably to the moral character"

Read this inspiring perspectives coauthored by the Worm Resource directors and worm Nobel Laureates! 4 Nobel Prizes and how they were enabled by major NIH-supported research resources (the Caenorhabditis Genetics Center, WormBase, and WormAtlas) www.pnas.org/doi/10.1073/...

The promise of TIL therapy for glioblastoma www.cell.com/trends/cance... authors.elsevier.com/a/1m5yH8Z12y... @dukeneurosurgery.bsky.social @neurosurgucsf.bsky.social

The promise of TIL therapy for glioblastoma

Tumor-infiltrating lymphocyte (TIL) therapy has demonstrated efficacy in refractory melanoma and durable responses in lung cancer. Glioblastoma presents distinct challenges for immunotherapy, includin...

cell.com

Yet another great reason to live in Europe!! Multilingualism protects against accelerated aging 😀 An analysis of aging in >86,000 participants across 27 European countries Amoruso et al, Nature Aging 🧪⏳ www.nature.com/articles/s43...

Conrad Hal Waddington was born OTD in 1905. His “epigenetic landscape” is a diagrammatic representation of the constraints influencing embryonic development. On his 50th birthday, his colleagues gave him a pinball machine on the model of the epigenetic landscape. 🧪 🦫🦋 🌱🐋 #HistSTM #philsci #evobio

Even chimpanzees think rationally and weigh the evidence when making a choice ;-) @science.org www.science.org/doi/10.1126/...

Chimpanzees rationally revise their beliefs

The selective revision of beliefs in light of new evidence has been considered one of the hallmarks of human-level rationality. However, tests of this ability in other species are lacking. We examined...

science.org

Back then, it took almost 40 years for his work to be discovered, and even today science communication remains flawed. We must get better at finding and evaluating science and remember that major discoveries may emerge from non-prestigious institutes and appear in non-glamorous journals.

Senior Research Tech (Duke) – tumor immunobiology lab. Work with tumor/blood/CSF samples, culture patient-derived cell lines, assist single-cell assays, and support & lead research. Bio degree + research exp required. No visa sponsorship. Title may vary. Apply → careers.duke.edu/job-invite/2...

Paul Mischel is championing the importance of odd rings of DNA in tumors—and their promise as targets for cancer therapy @science.org www.science.org/content/arti...

We need to do more to find effective treatments for leptomeningeal metastasis from solid tumors but this commentary from our team shows we are making some progress as a field! @dukemets.bsky.social @dukecancer.bsky.social rdcu.be/eySK8

A HER3-targeting antibody–drug conjugate for leptomeningeal metastasis

Nature Medicine - The phase 2 TUXEDO-3 trial identifies the HER3-targeting antibody–drug conjugate patritumab deruxtecan as a promising new therapeutic option for patients with leptomeningeal...

rdcu.be

Are you a top US-based scientist wanting to relocate to Australia? We are now calling for formal applications from both Australian and non-Australian citizens based in the US whose work is internationally recognised as exceptional. 📅 Applications close: Aug 29, 2025 🔗 science.org.au/gtap/?utm_so...

'Using a genome-wide in vivo CRISPR screen, we identified phosphodiesterase 5 & its substrate cGMP as key modulators of DC migration. Advanced tumours disrupted cGMP synthesis in DCs to decrease their motility, while PDE5 perturbation preserved the cGMP pool to restore DC migration' #TumorImmunology

Rescuing dendritic cell interstitial motility sustains antitumour immunity - Nature

Disruption of dendritic cell (DC) interstitial motility in the tumour microenvironment promotes immune evasion, and enhancement of DC interstitial motility offers a route for DC-centric immunotherapy.

nature.com

A study has found a promising new way to attack high-grade gliomas (HGG), by targeting the cells surrounding a tumour. The brilliant findings, led by Pofessor Misty Jenkins, Zoe Day and Dr Ryan Cross are now published in Nature’s npj Precision Oncology. www.nature.com/articles/s41...

It seems that only the science community is noticing that NIH and NSF budgets are cut 40% and 55% in the budget bill, respectively. If you live in Maine, West Va, Pennsylvania, Alabama, or Louisiana, CALL YOUR SENATOR as they could make a difference. See below. prospect.org/politics/202...

Will the Senate Save NIH?

Rescuing biomedical research is every bit as important as saving Medicaid.

prospect.org

This would be a great time for everyone to be cool when reviewing manuscripts and *not* request $25,000 worth of new experiments that don’t substantially advance or validate the study...

Delighted to be back in Melbourne to speak at the BCC symposium, listen to exciting scientific presentations and to be with friends @wehi-research.bsky.social @saskiafreytag.bsky.social

🧪

Ed Yong@edyong209.bsky.social · last yr.

I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding. It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job. unbreaking.org/issues/medic...

1/3 PLEASE READ, LIKE, REPOST this "1/3" post There is a Senate Hearing May 14th with RFK Jr to discuss Trump's proposed HHS budget. Please find call/email the members of the committee every day until then (I have compiled contact info for the members in post 2/3)

Can an LLM system become conscious? This question has generated significant debate and too much hype. Here's a paper from @cp-trendsneuro.bsky.social on what neuroscience has to say about that shine-lab.org/wp-content/u...

JCI - IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models www.jci.org/articles/vie...

A Spatial Multi-Omic Framework Identifies Gliomas Permissive to TIL Expansion www.biorxiv.org/content/10.1...

Integrated Proteogenomic Characterization of Glioblastoma Evolution: Overcoming Barriers to Develop Personalized Treatment Strategies dailynews.ascopubs.org/do/integrate...

This #science exciting! Collaborate, #clincaltrials, nurses, scientists - my co-lead H Rizos🤩. #immunotherapy 4 #GBM #glioblastoma Handed draft trial design+drugs to @jimwhittle.bsky.social @braincancercentre.bsky.social @sydneyuni.bsky.social @melanomaau.bsky.social www.nature.com/articles/s41...

Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma - Nature Medicine

A patient with newly diagnosed glioblastoma was safely treated with neoadjuvant nivolumab, relatlimab and ipilimumab before maximal resection, with comprehensive immune profiling showing the induction...

nature.com