What if you got to work with some of your best friends on a science project? I can't publish how fun this was, but I can show you the data (🧵)! Last week, we posted our second neutrophil swarming paper to bioRxiv and I wanted to post my favorite videos here~ www.biorxiv.org/content/10.6...

Such beautiful work soon to be in textbooks! Congratulations to Alison @alisonkickuth.bsky.social and the lab @brugueslab.bsky.social!

Brugues Lab@brugueslab.bsky.social · 7mo ago

Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de

How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926

To recognise and celebrate @svobodalab.bsky.social's pivotal contribution to Woodstock Bio2 + Night Science, #TCTeAC, I am starting this "What Petr Svoboda did at Woodstock?" thread. If you were there - #contribute and #retweet. "Petr Didn’t Submit an Abstract. #TCTeAC Submitted to Him."

Our study on endothelial mechanics made the news! 🤩 Super nice and clear article on our findings and their implications. www.snexplores.org/article/how-...

Here’s why your blood vessels don’t burst under pressure

Cells lining the blood vessels reorganize their inner structures to handle stressful boosts in pressure.

snexplores.org

it appears your safe back-up post doc project wasn’t so risk free after all, mr. bond

Amazing defense by @alisonkickuth.bsky.social! Congratulations on the beautiful thesis!

Alison Kickuth@alisonkickuth.bsky.social · last yr.

I successfully defended my PhD thesis this week! Thank you @brugueslab.bsky.social, @poldresden.bsky.social and @mpi-cbg.de for the great time over the last years!

Very happy and excited to share our latest work linking actin nematodynamics and endothelial cell mechanics under anisotropic tension, now published in @natphys.nature.com ! rdcu.be/eigWi @ipparis.bsky.social @polytechniqueparis.bsky.social

Interplay of actin nematodynamics and anisotropic tension controls endothelial mechanics

Nature Physics - Blood flow through a vessel deforms vessel walls. Cells lining these walls sense the changes in pressure as blood flows and reorient their actin fibres in the direction of largest...

rdcu.be

Looking for a student or postdoc! Want to combine evolutionary analysis + structural modeling with in vitro biochemistry & fluorescence microscopy? Help us uncover new protein-protein interactions — from in silico to in vitro. Join us at @istaresearch.bsky.social 👉 looselab.org 🧬💡🔬🎡

REPOSTING this here just to officially leave "the other place" Our work on the role of endogenous electric fields in guiding collective cell migration during #morphogenesis is out @naturematerials.bsky.social nature.com/articles/s41...

Stretch-induced endogenous electric fields drive directed collective cell migration in vivo - Nature Materials

Electric fields guide collective cell migration in developing embryos of Xenopus laevis via a voltage-sensitive phosphatase.

nature.com

Very happy that our new paper on social distancing during epidemics has just come out in @pnas.org! With @molinajohnj.bsky.social, Ryoichi Yamamoto, and Matthew S. Turner. Understanding Nash epidemics | PNAS www.pnas.org/doi/10.1073/...

In fun news, a video of mine won the UCLA Broad Stem Cell Research Center's Imaging Competition! You can see a muscle cell (a myoblast) fusing into a moving myotube. These myotubes mature to become our muscle fibers. They are beautiful cells! 🤩 www.youtube.com/watch?v=g6xK...

Muscle cell fusing into a proto-muscle fiber

YouTube video by UCLA Broad Stem Cell Research Center

youtube.com

The Image & Optics Facility @ Institute of Science and Technology Austria is expanding it’s image analysis services and has a vacant position for a service oriented *Image Analysis Specialist* with a strong interest for data infrastructure organization🔬🧑‍💻📈 - sharing is much appreciated

Job details

Job details

ista.ac.at

Excited about protein biochemistry, fluorescence microscopy, and image analysis? Curious how proteins drive bacterial division or define organelle identity? Join us at ISTA! Apply to the PhD program by Jan 8th: gradschool.ist.ac.at

Entropy is one of those formulas that many of us learn, swallow whole, and even use regularly without really understanding. (E.g., where does that “log” come from? Are there other possible formulas?) Yet there's an intuitive & almost inevitable way to arrive at this expression.

New paper out with the Kicheva group by S. Lehr and D. Bruckner! 🧪 Develops a new 2D neural tube organoid, and models its striking self-organized patterns! Key finding: patterning via 2-phase dynamics of BMP, which acts like a temporal relay balancing sequential fate decisions! bit.ly/3OJti4G

As promised, here a fast acquisition of a migrating cell videoed under a microscopy, look those membrane dynamics @ the leading edge ! Bonus: nuclear deformation once the cell rear snaps. (Fluo nucleus, for the #fluorescencefriday) @focalplane.bsky.social @cellcommlab.bsky.social #CellMigration 🧪🔬

I have moved to 🦋 as well ! Looking forward to reconnecting with old and initiating new science contacts here

Ivaska Lab@ivaskalab.bsky.social · 2y ago

Introductory post on 🦋! We're a research group headed by Prof. Johanna Ivaska interested in understanding how integrins contribute to every step of cancer progression. We're located at the Turku Bioscience Center in Turku, Finland! Find out more about us and our interests here: ivaskalab.utu.fi

Mix two motors of opposite polarity with microtubules and they will partition space ! Microtubules will get organized in polar and active barriers, sorting the two motors in separated domains, leading to the emergence of a new type of patterns. #morphogenesis doi.org/10.1073/pnas... (1/n)

🌱🔬The most time-intensive and difficult paper of my PhD is now published in #mSystemsJ! I'm proud of this work and also how much I've grown since I first started this experiment. Read on to learn more about how the functions of bacterial communities impact plant growth and health. 👇

I thought #fluorescencefriday would be a good opportunity for my first post here. Here are some crazy actin dynamics imaged with TIRF

Before I start posting about newer results on this platform, here is a video from our most recent paper -- www.nature.com/articles/s41...

The cell contacts its chloroplast area by up to 40%! Where does all the material go? Smart design! Chlorophyll absorbs a lot - what is crucial is not its volume but is a high 2d-projected area for example a network. Fast contractions are driven via buckling of the network strands into the voids.

💥Beyond happy 💥 Our work is now published in PNAS! www.pnas.org/doi/10.1073/... With Gloria Canales & @mazi1.bsky.social we studied how the single celled alga Pyrocystis lunula 🌙 move their chloroplast in response to strong light. Get ready for some fun mechanics, signals and organelle motion! 🧵

Introductory post on 🦋! We're a research group headed by Prof. Johanna Ivaska interested in understanding how integrins contribute to every step of cancer progression. We're located at the Turku Bioscience Center in Turku, Finland! Find out more about us and our interests here: ivaskalab.utu.fi

Ivaska cell adhesion and cancer Lab

Integrins, matrix, motility and mechanotransduction in cancer

ivaskalab.utu.fi

We have an inherent intuition for the progression of time. In entropy producing systems the arrow of time should appear clear and a reversed movie feels thereby wrong. Look at these macroscopic active spheres and try to figure out whether the movie has been reversed.(1/6) arxiv.org/abs/2409.16734

Myoblasts flows on nematics tracks!

Roux Lab, Geneva@rouxlab.bsky.social · 2y ago

It's good to resocialize on bluesky with scientists long seen on Twitter! As a #welcome image, we share a beautiful image of nematic myoblasts covering an alginate capsule taken by Claire Dessalles @clairedessalles.bsky.social... and their flows!

#FluorescenceFriday

Michael Riedl@mriedl.bsky.social · 2y ago

Polymerizing actin creates fireworks that are a sight to behold. This excitable medium produces polymerizing waves similar to those observed in other context. The parallels I tried to lay out in this perspective piece last year: tinyurl.com/53cbxm4v (LifeAct-GFP in Endothelial Cell)

Introducing "3D Micropatterned Traction Force Microscopy", our new joint work with Pere Roca-Cusach's lab, led by amazing Laura Faure and Manu Gómez. Hope you find it useful!👇 onlinelibrary.wiley.com/doi/full/10....

Another good example of exciting science from the Barcelona team!

Xavier Trepat@xaviertrepat.bsky.social · 2y ago

Introducing "3D Micropatterned Traction Force Microscopy", our new joint work with Pere Roca-Cusach's lab, led by amazing Laura Faure and Manu Gómez. Hope you find it useful!👇 onlinelibrary.wiley.com/doi/full/10....