📣 The Singh Lab opens at Fox Chase Cancer Center in Spring 2027, where I will be starting as an Assistant Professor!📣 Excited to continue studying how protein biophysics shapes drug response. I am hiring across all levels and disciplines! Apply on the "Join" page ( & spread the word!): singhlab.bio

Out now in #JACS work led by the talented @nathanieldhess.bsky.social on protein folding inside condensates!! pubs.acs.org/jacsat/artic...

And this on stability of RRMs in condensates bsky.app/profile/lind...

Kresten Lindorff-Larsen@lindorfflarsen.bsky.social · 2y ago

The ability to model both folded domains and disordered regions in condensates means that we can now begin to use CALVADOS simulations to ask how and why the condensate environment changes protein folding stability 🧪 doi.org/10.1002/pro....

Very excited that our work is now officially published in @jacs.acspublications.org (doi.org/10.1021/jacs...)! I am very grateful to my advisor @jerelleaj.bsky.social, the reviewers, editor, funders, and all the people I've had discussions with on this project over the years!

Our new paper is out! We asked how small molecules influence biomolecular condensation. Our findings help identify molecules and rxns that regulate physiology and inform therapeutic development. Susceptibility and regulation of biomolecular condensates by solutes | PNAS www.pnas.org/doi/10.1073/...

Laboratory of Soft and Living Materials @SoftLiv_Cornell@softliv.bsky.social · 7mo ago

Happy to share our first preprints from work originating at Cornell! Takumi's paper describes how small molecules shift phase equilibria of condensates by focusing on the dilute-phase response. It shows how metabolites may tune stability and material properties. www.biorxiv.org/content/10.6...

You're probably already doing science advocacy — you just might not call it that. Our new commentary (www.nature.com/articles/s41...) makes the case that every scientist has a role, and that advocacy takes many forms. Find and embrace yours! @natcellbio.nature.com @vfarm15.bsky.social

Every scientist has a role in advocacy - Nature Cell Biology

In this Comment, we call on scientists to share their stories. Through casual conversation or prepared presentations, with images or essays, scientists can advocate for their research and reach taxpay...

nature.com

Out now in #CurrentOpinioninStructuralBiology! Our perspective on progress toward linking single-molecule behavior and emergent condensate properties! Led by Pablo Garcia and @ananyac2000.bsky.social 🙂 www.sciencedirect.com/science/arti...

Progress toward linking single-molecule behavior and condensate material properties

Biomolecular condensates exhibit distinct material properties that are intimately linked to their functions. A major open question is how the properti…

sciencedirect.com

New preprint! 🧪 What happens when phase separation couples to a nematic transition? 🫧 By combining experiment and theory 🔬, we find some pretty wild ternary phase diagrams! 🌈 Congrats on this milestone, Sully! Check it out here. arxiv.org/abs/2605.26338

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

Pearling drives mitochondrial DNA nucleoid distribution | Science www.science.org/doi/10.1126/...

Pearling drives mitochondrial DNA nucleoid distribution

The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...

science.org

Postdoctoral researcher @isaacsiuwong.bsky.social in the @hymanlab.bsky.social @mpi-cbg.de is 2026 Grass Fellow @grassfoundation.bsky.social @mblscience.bsky.social. 🎉 He will pursue his project “Dancing diatoms as a proto-neural model” at MBL for 14 weeks. www.mpi-cbg.de/news-outreac...

Isaac Siu-Shing Wong is MBL 2026 Grass Fellow

MPI-CBG postdoctoral researcher joins Marine Biological Laboratory, working in the Grass Laboratory for research project.

mpi-cbg.de

Our work on how oligomerization can enable selectively targeting intrinsic disorder with small molecules is now out in Science Advances: www.science.org/doi/10.1126/...). Congratulations Stase Bielskute and @borjaml.bsky.social and thanks to the collaborators and funders !

Oligomerization enables the selective targeting of an intrinsically disordered region by a small molecule

The druggability of intrinsically disordered regions.

science.org

Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations. www.nature.com/articles/s41...

RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology

Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

nature.com

Happy to share our first preprints from work originating at Cornell! Takumi's paper describes how small molecules shift phase equilibria of condensates by focusing on the dilute-phase response. It shows how metabolites may tune stability and material properties. www.biorxiv.org/content/10.6...

Here’s another condensate paper from the lab. We revisit biomolecular condensation—phase separation in protein suspensions—through the lens of critical phenomena. Kaarthik did excellent work characterizing mechanical properties and comparing their scaling behavior to the 3D Ising universality class.

Laboratory of Soft and Living Materials @SoftLiv_Cornell@softliv.bsky.social · 7mo ago

Our second Cornell-era preprint is also out! Kaarthik's paper discusses the gap between cellular and in vitro condensates. In cells, condensates are low-contrast (small partition coefficients), enabling a wide range of responses. Congrats, Kaarthik and the team! www.biorxiv.org/content/10.6...

Our second Cornell-era preprint is also out! Kaarthik's paper discusses the gap between cellular and in vitro condensates. In cells, condensates are low-contrast (small partition coefficients), enabling a wide range of responses. Congrats, Kaarthik and the team! www.biorxiv.org/content/10.6...

On the cover of #JCP, Pablo’s work on “Condensate Deborah Numbers” pubs.aip.org/aip/jcp/arti...

Partition Coefficients Reveal Changes in Properties of Low-Contrast Biomolecular Condensates https://www.biorxiv.org/content/10.64898/2026.02.20.707107v1

Pablo’s work on “condensate Deborah numbers” is now out in #JCP!! Selected as Editor’s Pick and featured as a #Scilight pubs.aip.org/aip/jcp/arti...

Molecular origins of viscoelasticity in biomolecular condensates

Biomolecular condensates are membraneless organelles that compartmentalize functions in living cells. Formed by the phase separation of biomolecules, condensate

pubs.aip.org

Jerelle Joseph@jerelleaj.bsky.social · 12mo ago

Is there a way to directly connect microstructural dynamics of condensates to their mechanical response? In his new pre-print, Pablo presents a “condensate Deborah number” that does just that! www.biorxiv.org/content/10.1...

Many condensates can be described as active soft materials that generate molecular fluxes. Here we develop a new #nonequilibrium approach (TRACE) to study molecular transport through condensates! Work led by Yashraj Wani!! www.biorxiv.org/content/10.6...

How does protein folding change inside biomolecular condensates? Our new preprint put forwards a framework for predicting this!! 🥳🥳🥳🥳 work by the talented @nathanieldhess.bsky.social

Nate@nathanieldhess.bsky.social · 8mo ago

I am very excited to share our pre-print that was just released on the bioRxiv entitled "Biomolecular Condensates Dictate the Folding Landscape of Proteins" doi.org/10.64898/202... Very grateful for @jerelleaj.bsky.social and the members of the Joseph Group for their support on this project! (1/4)

I am very excited to share our pre-print that was just released on the bioRxiv entitled "Biomolecular Condensates Dictate the Folding Landscape of Proteins" doi.org/10.64898/202... Very grateful for @jerelleaj.bsky.social and the members of the Joseph Group for their support on this project! (1/4)

Biomolecular Condensates Dictate the Folding Landscape of Proteins https://www.biorxiv.org/content/10.64898/2026.01.12.699095v1

Now online - the Review "Structured protein domains enter the spotlight: modulators of #biomolecularcondensate form and function" from Nathaniel Hess and @jerelleaj.bsky.social. #PhaseSeparation #ProteinProteinInteraction #Oligomerization #ProteinRNAInteraction authors.elsevier.com/sd/article/S...