Very proud to be part of this beautiful work carried out by Ale :)!

Irene Miguel-Aliaga@irenemiguel-aliaga.bsky.social · last wk.

Read about our latest work here www.cell.com/cell/fulltex... or let Alessandro tell you all about it (link below)!

Now online! The sex and reproductive plasticity of intestinal muscles instruct gut size

Excited to announce "The Body in Dialogue" workshop @institutducerveau.bsky.social! 4 sessions on how the brain talks to the body across the animal kingdom: My session features Ana Domingos, @karalmarshall.bsky.social, Denis Burdakov & Michael Krashes. More announcements coming soon, stay tuned!

We’re recruiting! Exciting opportunities in our lab supported by a @wellcometrust.bsky.social Discovery Award. • Postdoctoral researchers • Research assistant/PhD students Join us to study how neural circuits drive decision-making. Deadline 26/04 Learn more and Apply here: rezavallab.org

Carolina Rezaval@crezaval.bsky.social · 5mo ago

Deeply honoured to have been awarded a Wellcome Trust Discovery Award to study how competition is encoded in the brain. This builds on the discoveries of outstanding past/present lab members. Grateful to mentors/collaborators/colleagues for their support. We are recruiting postdocs/PhD students.

A very interesting and thought provoking view on mitochondrial lactate!

Mitochondrial lactate venting limits oxidative stress

The main function of mitochondria is to generate ATP by oxidizing pyruvate to CO2. Rauseo et al. show that matrix pyruvate is also converted to lactate, which is released to the cytosol via the MPC to...

cell.com

Our new preprint is out! A state-dependent neural circuit resolves approach–avoidance conflicts www.biorxiv.org/content/10.6... Fantastic work led by Devika Bodas, with key contributions from Marine Balcou, and a great collaboration with Lisa Scheunemann Lab, fearuting Şevval Demirci.

Wonderful paper nicely showing mitochondria as a memory booster, a must read! Congrats @jdejuan-sanz.bsky.social and team :)

Jaime de Juan-Sanz@jdejuan-sanz.bsky.social · 6mo ago

Can we make brains “smarter”? By boosting mitochondrial metabolism in neurons of memory circuits, we improved memory in flies and mice. Thrilled to see this work out - congrats to @amrapalianjali.bsky.social for spectacular work, and to all lab members for invaluable contributions!

Happy to share our conceptual review 😉 where we propose the gut not as a “second brain”, but as a foundational, ancient visceral brain. We propose that decentralising the brain starts with the gut. Time to enter the Enterarchon 🤯

Dafni Hadjieconomou @drosostalis.bsky.social · 7mo ago

🧨 Check out this peeps🧨 I am very happy with the outcome of this thought baby! @neurogut.bsky.social @michaelrera.bsky.social and Mael Lemoine (yes, a philosopher) twisted our brains over preparing this conceptual review! We give you the "Enterarchon" Enjoy it! www.sciencedirect.com/science/arti...

Our CytoTape work is published today in Nature @nature.com! CytoTape is a genetically encoded, flexible, intracellular protein tape recorder for spatiotemporally scalable and multiplexed recording of cellular activities continuously across weeks in vitro and in vivo. www.nature.com/articles/s41...

I am excited to share our review that was published in Molecular Oncology @moloncology.bsky.social entitled "Tumour–host interactions in Drosophila: mechanisms in the tumour micro- and macroenvironment" febs.onlinelibrary.wiley.com/doi/10.1002/...

Delighted to have been part of this amazing team! ✨

Pierre Le Merre@pierrelemerre.bsky.social · 7mo ago

Main postdoc study out! We can redefine prefrontal cortex regions with single-unit activity! Grateful to @carlenlab.bsky.social and @weltgeischt.bsky.social who made this crazy project real. Thanks to all co-authors, collaborators, and reviewers. www.nature.com/articles/s41...

Your gut has a sex, and it matters! 🔥 In females, the ovary sends a relaxin hormone signal to enteric neurons, switching on gut enlargement and increased feeding after mating. So excited my postdoc work is finally out as a preprint 🥳 www.biorxiv.org/content/10.6...

Dafni Hadjieconomou @drosostalis.bsky.social · 7mo ago

📣First preprint of the lab📣 Did that really happen?😅 Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes. www.biorxiv.org/content/10.6...

Three layers of sexual dimorphism within the same neurons... three steps to reproduce. Congrats @neurogut.bsky.social @drosostalis.bsky.social and team!

Dafni Hadjieconomou @drosostalis.bsky.social · 7mo ago

📣First preprint of the lab📣 Did that really happen?😅 Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes. www.biorxiv.org/content/10.6...

Your gut has a sex, and it matters! 🔥 In females, the ovary sends a relaxin hormone signal to enteric neurons, switching on gut enlargement and increased feeding after mating. So excited my postdoc work is finally out as a preprint 🥳 www.biorxiv.org/content/10.6...

Dafni Hadjieconomou @drosostalis.bsky.social · 7mo ago

📣First preprint of the lab📣 Did that really happen?😅 Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes. www.biorxiv.org/content/10.6...

📣First preprint of the lab📣 Did that really happen?😅 Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes. www.biorxiv.org/content/10.6...

Genetic sex of enteric neurons enables ovarian relaxin to gate maternal gut plasticity

Animals must align intestinal plasticity and feeding with reproductive state, yet the checkpoint that gates these adaptations is unknown. Here we show that an ovary-to-enteric-neuron axis gates the on...

biorxiv.org

I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!

bioRxivpreprint@biorxivpreprint.bsky.social · 7mo ago

Evolutionary dynamics of temporal transcription factor series in the insect optic lobe https://www.biorxiv.org/content/10.64898/2026.01.08.698497v1

Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation. Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com

Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism

Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy ...

nature.com

Textbooks said neurons don’t burn fatty acids for energy🤔. Our study delivers the first in vivo demonstration that fatty acid oxidation in defined memory neurons fuels memory formation. Closing chapter of my PhD 🥳, out today in Nature Metabolism💥 @natmetabolism.nature.com

Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism

Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy ...

nature.com

Cool cool cool!

Oxytocin modulates respiratory heart rate variability through a hypothalamus–brainstem–heart neuronal pathway - Nature Neuroscience

Buron et al. show that oxytocin enhances heart rate variability linked to breathing during recovery from stress. This calming and cardio-protective effect is produced through a hypothalamus–brainstem ...

nature.com

I’m thrilled to share my postdoc work and the first paper from the McKinley Lab! 🎉 @karalmckinley.bsky.social We built the first transgenic model of menstruation in mice. We used it to uncover how the endometrium organizes and sheds during menstruation. 🧪 www.biorxiv.org/content/10.1... 🧵

Induction of menstruation in mice reveals the regulation of menstrual shedding

During menstruation, an inner layer of the endometrium is selectively shed, while an outer, progenitor-containing layer is preserved to support repeated regeneration. Progress in understanding this co...

biorxiv.org

If you find yourself at @edrc2025.bsky.social please check my wonderful postdoc's talk @neurogut.bsky.social at the gut workshop this afternoon. Gut, sex, reproduction, our new story! In combo with @irenemiguel-aliaga.bsky.social! @fly-jedi.bsky.social #EDRC2025

A fantastic way of imaging lipids!

Itay Budin@ibudin.bsky.social · 11mo ago

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Dual-cycle CO2 fixation enhances growth and lipid synthesis in Arabidopsis thaliana | Science www.science.org/doi/10.1126/... Woooooow

Dual-cycle CO2 fixation enhances growth and lipid synthesis in Arabidopsis thaliana

Carbon fixation through the Calvin-Benson-Bassham (CBB) cycle accounts for the majority of carbon dioxide (CO2) uptake from the atmosphere. The CBB cycle generates C3 carbohydrates but is inefficient ...

science.org

Glia feed neurons upon starvation: our 2022 Nature Metabolism paper revealed a glia-to-neuron ketone body shuttle 💪 #Memories #EnergyMetabolism #Glia @naturemetabolism.bsky.social ky.social www.nature.com/articles/s42...

This is awesome! Lipid probes for quantitative imaging of lipid transport. A real need in the lipid field! @nadlerlab.bsky.social

Quantitative imaging of lipid transport in mammalian cells - Nature

Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

nature.com