These images of First Nations community members evacuating Collins, Ontario on motorboats are absolutely surreal www.facebook.com/reel/1548244...

Luke LeBrun@lukelebrun.ca · 3w ago

These photos of FNs community members fleeing their homes by boat are genuinely apocalyptic (Photo via Wayne Wastaken of Collins, Ontario, who says his “hometown is gone”) www.facebook.com/share/r/1ArN...

MIT Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86 news.mit.edu/2026/mit-pro... #neuroscience

MIT Professor Susumu Tonegawa, renowned molecular biologist and Nobel laureate, dies at 86

Susumu Tonegawa, a renowned MIT professor of biology and neuroscience and a Nobel laureate, has died at the age of 86. His discovery of how the immune system generates many different antibodies earned...

news.mit.edu

So excited to be part of this one! Now officially out in Annual Review of Neuroscience 🎉 www.annualreviews.org/content/jour...

Ecological Visual Processing in the Mouse

Visual systems evolved to extract behaviorally relevant information while animals move through and interact with their world. Such ecological vision differs fundamentally from standard laboratory paradigms in many key aspects, making this a much harder problem for the brain to solve, and for the neuroscientist to study. However, emerging technologies and experimental approaches have enabled investigation of visual computations under these ecological conditions. These approaches are particularly powerful in the mouse, combining well-developed genetic tools, high-throughput recordings, and quantifiable ethological tasks. Here we review computations that are engaged in ecological contexts, including active sensing, motion processing, scene analysis, distance estimation, and spatial perception. We delineate experimental approaches that engage these computations and synthesize current understanding of their neural implementations based on mouse research. These studies reveal how ecological vision engages distinct processing strategies and novel neural circuitry, while highlighting the vast territory that remains unexplored in understanding real-world visual computation.

annualreviews.org

Spencer LaVere Smith@spencerlaveresmith.bsky.social · 3w ago

Ecological Visual Processing in the Mouse - with @michaelgoard.bsky.social @crisniell.bsky.social @mbeyeler.bsky.social Visual computations that are engaged in ecological contexts: active sensing, motion processing, scene analysis, distance estimation, and spatial perception. doi.org/10.1146/annu...

New in PLOS Comp Bio, cool work from @timothyoleary.bsky.social showing that representational "drift" (lol, sorry for the scare quotes, Tim!), follows non-Gaussian statistics that can be beneficial for adaptive decoding: journals.plos.org/ploscompbiol... #neuroscience 🧪

Statistics of cortical representational drift can enable robust readout

Author summary Percepts, actions and experiences, such as the appearance of an apple and its flavour, are represented in the activity of populations of neurons in various parts of the brain. For decad...

journals.plos.org

When reality surpasses fiction! Top: fictional forecast for August 2050, broadcast by French TV in 2014 to warn about the consequences of global warming. Bottom: Real French forecast for yesterday, June 22, 2026.

Our latest story is finally in preprint! 🧠✨ How does the brain solve the (hierarchical) credit assignment problem efficiently? Cell-type-specific cortical feedback holds the key, closely approximating backprop. Paper: doi.org/10.64898/202...

Cell-type-specific cortical feedback coordinates hierarchical credit assignment

Learning is thought to arise from synaptic modifications embedded in brain-wide circuits, yet how such circuits coordinate plasticity to support complex behaviour is not known. Inspired by deep learni...

doi.org

People like to dunk on MATLAB now, but it’s hard to overstate how large an advance it was at the time and the impact it has had on scientific computing. RIP Cleve Moler www.nytimes.com/2026/06/11/s...

Cleve Moler, Who Unlocked the Power of Computing for Millions, Dies at 86

nytimes.com

Cool to see this new work relating bursts and learning in more physiological details out on Biorxiv: doi.org/10.64898/202... @somnirons.bsky.social

Cell-type-specific cortical feedback coordinates hierarchical credit assignment

Learning is thought to arise from synaptic modifications embedded in brain-wide circuits, yet how such circuits coordinate plasticity to support complex behaviour is not known. Inspired by deep learni...

doi.org

Recent work from the lab: big contrast between the synaptic dynamics of excitatory and inhibitory synapses!

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2mo ago

Functional Continuum of GABAergic Synaptic Dynamics Reflects Genetic Identities https://www.biorxiv.org/content/10.64898/2026.06.09.731181v1

Incredibly grateful to @cmiehl.bsky.social and @gjorjulijana.bsky.social for their thoughtful and spot-on Preview "Novelty beyond counting" of our recent work in Neuron with @modirshanechi.bsky.social and @gerstnerlab.bsky.social! 🧠✨ It's a real honor 🙏 www.cell.com/neuron/fullt...

How do neural circuits in the brain implement normalization? 🧠 In our new paper, we show that just normalizing sensory input isn't enough. Crucially, we must also normalize the error signals! 🧵👇 Paper: arxiv.org/abs/2603.17676

Inhibitory normalization of error signals improves learning in neural circuits

Normalization is a critical operation in neural circuits. In the brain, there is evidence that normalization is implemented via inhibitory interneurons and allows neural populations to adjust to chang...

arxiv.org

To accompany my textbook (Computational Foundations of Cognitive Neuroscience) and the class I taught this semester, I'm open-sourcing my lectures slides: gershmanlab.com/lectures.html I'll continue to update these as I improve them.

Going from neural activity to blood flow just became easier! Two brainwide populations, each with its neurovascular coupling. (But going backwards... is now a tad more complicated.) By @agnesland.bsky.social & team. Thanks @intlbrainlab.bsky.social @wellcometrust.bsky.social @simonsfoundation.org

Agnès Landemard@agnesland.bsky.social · 4mo ago

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states! Out today in Nature: rdcu.be/fdC2A @uclbrainscience.bsky.social

Nice summary of our recent work on neural population geometry and generalization across multiple tasks with shared latent structure. Thank you @natmesanash.bsky.social and @thetransmitter.bsky.social for the great article! Paper: www.nature.com/articles/s41...

The Transmitter @thetransmitter.bsky.social · 4mo ago

A single equation governs the brain’s flexible behavior and predicts how well brains and artificial networks can generalize across tasks. #neuroskyence By @natmesanash.bsky.social www.thetransmitter.org/systems-neur...

For those interested in the history of psychedelic research… I wrote a narrative piece describing studies of psychedelic effects on serotonergic neurons in the dorsal raphe, from late 1960s to 1980s: journals.sagepub.com/doi/10.1177/...

Dorsal Raphe Revisited: A Systems Neuroscience Lens on Psychedelic Drug Action - Alex C. Kwan, 2026

Psychedelics rose to prominence in the 1960s, around the same time when neurobiologists identified the midbrain raphe as the brain’s primary source of serotonin...

journals.sagepub.com

Categorization is ‘baked’ into the brain — a Perspective by Lisa Feldman Barrett & Earl K. Miller @lisafeldmanbarrett.com @earlkmiller.bsky.social #neuroscience #neuroskyence www.nature.com/articles/s41...

Categorization is ‘baked’ into the brain - Nature Reviews Neuroscience

Categorization, the grouping of objects, living organisms, actions or events into equivalence clusters, is fundamental to adaptive behaviour. In this Perspective, Barrett and Miller discuss evidence t...

nature.com

Functional synaptic connectivity shapes spine stability in the hippocampus "Spines with large responses exhibited larger volume and higher stability compared to unresponsive spines." www.nature.com/articles/s41...

Functional synaptic connectivity shapes spine stability in the hippocampus - Nature Communications

In this study, the authors find that synaptic strength predicts spine size and long-term stability via in vivo imaging together with optogenetic stimulation in awake mice. While individual synapses sh...

nature.com

doi.org/10.1038/s415...

Entorhinal cortex represents task-relevant remote locations independently of CA1 - Nature Neuroscience

Neurons in medial entorhinal cortex collectively represent discrete nonlocal positions during immobility. During this nonlocal coding, CA1 is uncoupled from entorhinal cortex. These representations ar...

doi.org

Stoked this is finally out! We ask: how can we simulate the brain from the bottom up? It's not sufficient to grab the connectome and wire it up in silico! We need 1) ultrastructure 2) (causal) calibration data 3) functional data. Then we can build a simulation compiler. 1/

Konrad Kording@kordinglab.bsky.social · 4mo ago

Preprint out arguing that we should build the techology to translate (compile) molecularly annotated connectomes into dynamics. I think this is incredibly important. arxiv.org/abs/2603.25713

Episode #39 in #TheoreticalNeurosciencePodcast: On modeling neural population activity with mean-field models – with Tilo Schwalger theoreticalneuroscience.no/thn39 How can mean‑field models be systematically derived from the underlying microscopic dynamics of individual neurons?

An important piece on error-based learning in biological networks

Aaron Milstein@neurosutras.bsky.social · 4mo ago

Our latest publication grapples with how the brain could implement gradient descent by sending learning targets top-down, gating plasticity with dendritic inhibition, and updating synaptic weights with biologically observed learning rules like BTSP. www.cell.com/cell-reports...

We've created a tool to visualize the map of electric signals (LFPs) in the whole mouse brain. Different brain areas have electrical fluctuations that look more like a select number of areas, thus creating a map. nebulawang.github.io/brain-viz/ Details in this paper doi.org/10.1101/2025...

Come see our Cosyne 2026 posters! Friday: 2-069 (Atena & Manu), 2-096 (Julian), Saturday: 3-091 (Julia) More info zenkelab.org/2026/03/cosy...

I thought this was an exciting new theoretical perspective www.cell.com/neuron/fullt...

Linking neural manifolds to circuit structure in recurrent networks

Neural population activity can be described either by low-dimensional dynamics on neural manifolds or by single-neuron selectivities. Using a theoretical approach, Pezon et al. relate these two statis...

cell.com

Excited to be at #Cosyne2026! I'll be presenting my poster tomorrow during the Thursday session: [1-106] “A biologically inspired predictive coding algorithm with multiplicative and additive feedback”. With @colin-bredenberg.bsky.social and @tyrellturing.bsky.social

I’ll be presenting this work (plus some exciting new follow-up analyses!) tonight at poster [1-019], “A unifying theory of receptive field heterogeneity predicts hippocampal spatial tuning.” Come by and say hi! #cosyne26

Zach Cohen@zachcohen1.bsky.social · last yr.

Finally up on bioRxiv! A new study with @jdrugowitsch.bsky.social where we do a deep dive into the coding benefits of receptive field heterogeneity and come up with new ways to measure receptive fields! www.biorxiv.org/content/10.1... [1/n]

"neuro AI reckoning: can we move beyond the metaphor?"https://groundedneuro.substack.com/p/22-years-of-brain-science-what-cosyne?r=6l8iaw&utm_campaign=post&utm_medium=web&triedRedirect=true&_src_ref=go.bsky.app

this is great!

Renato Duarte@rcfduarte.bsky.social · 5mo ago

I tracked every keyword in 22 years of Cosyne abstracts to map how computational neuroscience evolved — from Bayesian brains to neural manifolds to LLMs — and where it's heading next.

Are you at #cosyne2026 and looking for a postdoc position? CATNIP = Neural Dynamics Lab is hiring! catniplab.github.io/postdoc-hiri...

The deadline for applying to the Methods in Computational Neuroscience summer course at MBL in Woods Hole is approaching (March 16)! An exciting course with an amazing lineup of lecturers in a beautiful location www.mbl.edu/education/ad...