Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of fragile X mice and identifies EPAC2 as a therapeutic target: doi.org/10.1016/j.ne... EPAC2 (exchange protein directly activated by cAMP 2) antagonist rescued circuit and behavioral phenotypes in Fmr1 KO mice.

Nature research paper: Feature-specific threat coding in lateral septum guides defensive action go.nature.com/4uv9qps

Feature-specific threat coding in lateral septum guides defensive action - Nature

The populations of CRHR2-expressing neurons in the lateral septum of mice involved in threat-related behaviour in response to environmental challenges are defined.

go.nature.com

Thalamic activity regulates interneuron density in the developing visual thalamus www.jneurosci.org/content/earl...

Thalamic activity regulates interneuron density in the developing visual thalamus

Neural activity is a fundamental driver of early circuit assembly, yet how it shapes the distribution of inhibitory neurons across sensory networks remains poorly understood. Establishing an appropria...

jneurosci.org

Is alcohol just a depressant? Not quite. Our new study, now published in final form in #JNeurosci, shows that alcohol rapidly activates neurons in the prefrontal cortex (PFC), and this effect depends on dopamine. www.jneurosci.org/content/46/2...

Activation by Alcohol of Prefrontal Layer 5 Pyramidal Neurons Depends on Ascending Dopaminergic Input

Short-term alcohol exposure modulates activity in reward-related regions such as the ventral tegmental area (VTA) and executive cortical regions such as the prefrontal cortex (PFC), potentially contri...

jneurosci.org

New voltage indicators from St-Pierre lab and collaborators: - FORCE1s: www.biorxiv.org/content/10.6... - JEDI3sub and JEDI3hyp: www.nature.com/articles/s41... Blog post about voltage imaging: spikesandbursts.wordpress.com/2018/11/06/v...

Designer indicators for two-photon recording of subthreshold voltage dynamics - Nature Methods

The genetically encoded voltage indicators JEDI3sub and JEDI3hyp enhance monitoring of subthreshold neuronal activity in the awake mouse brain using a variety of two-photon microscopy techniques.

nature.com

Tuft dendrites in frontal motor cortex enable flexible learning: www.science.org/doi/10.1126/...

A functional influence based circuit motif that constrains the set of plausible algorithms of cortical function elifesciences.org/reviewed-pre...

Finally online @natmethods.nature.com www.nature.com/articles/s41... This was a fun collaboration with @finkryan.bsky.social @massecklab.bsky.social @tpatriarchi.bsky.social @martinfuhrmann.bsky.social @campbell-lab.bsky.social @jangrundemann.bsky.social 🧪🧠🔬🧬

PinkyCaMP: an mScarlet-based calcium sensor with enhanced brightness, photostability and multiplexing capabilities - Nature Methods

PinkyCaMP is a red genetically encoded calcium indicator with improved brightness and photostability. Derived from mScarlet, it does not exhibit photoswitching upon blue light illumination and is ther...

nature.com

Jonas Wietek@jwietek.bsky.social · 8mo ago

@massecklab.bsky.social @finkryan.bsky.social 🥳👏🧠🐭🔬🧪🩷

How does blood flow relate to brain activity? We discovered that it reflects two neural populations affected oppositely by arousal. Together, they explain neurovascular coupling in all brain regions and brain states! Out today in Nature: rdcu.be/fdC2A @uclbrainscience.bsky.social

Molecular and functional dissection using CaMPARI-seq reveals the neuronal organization for dissociating optic flow-dependent behaviors: www.nature.com/articles/s41...

Molecular and functional dissection using CaMPARI-seq reveals the neuronal organization for dissociating optic flow-dependent behaviors - Nature Communications

In this study, the authors develop CaMPARI-seq to link neural activity with molecular profiles in larval zebrafish. They identify inhibitory pretectal neurons required for optomotor response, revealin...

nature.com

Infant Brains Tick at 4Hz – Resonance Properties of the Developing Visual System A ~4 Hz EEG response in infants (8-month-olds) emerges independently of visual stimulation frequency. elifesciences.org/reviewed-pre...

Developmental characteristics of spontaneous activity and functional connectivity in the fetal brain "As the fetal gestational age increased, spontaneous brain activity ↓ in the bilateral thalamus and ↑ in the bilateral anterior cingulate cortex." academic.oup.com/cercor/artic...

Developmental characteristics of spontaneous activity and functional connectivity in the fetal brain

Abstract. Investigating the developmental characteristics of fetal brain functional activity and connectivity is crucial for understanding normal developme

academic.oup.com

I don’t know if you saw the MASSIVE news announced by @erc.europa.eu today: from now on, if you get a B at step 1 you are eligible to apply at N+3(!!!) years. Say you got a B in STG2026 step 1, you thought you could apply in STG2028, but no: only in STG2029! erc.europa.eu/news-events/...

Applying for an ERC grant in the 2027 competitions: what you need to know

The ERC plans to launch the grant competitions under its 2027 Work Programme between July 2026 and June 2027, with the calls for proposals introducing several changes to the eligibility rules for appl...

erc.europa.eu

What happens in the prefrontal cortex when alcohol kicks in? Our new paper is out! We show that acute alcohol activates layer 5 pyramidal neurons in the prefrontal cortex, and that this activation requires dopaminergic signaling from the ventral tegmental area. www.jneurosci.org/content/earl...

Activation by alcohol of prefrontal layer 5 pyramidal neurons depends on ascending dopaminergic input

Short-term alcohol exposure modulates activity in reward-related regions such as the ventral tegmental area (VTA) and in executive cortical regions such as the prefrontal cortex (PFC), potentially con...

jneurosci.org

Functional synaptic connectivity shapes spine stability in the hippocampus "Spines with large responses exhibited larger volume and higher stability compared to unresponsive spines." www.nature.com/articles/s41...

Functional synaptic connectivity shapes spine stability in the hippocampus - Nature Communications

In this study, the authors find that synaptic strength predicts spine size and long-term stability via in vivo imaging together with optogenetic stimulation in awake mice. While individual synapses sh...

nature.com

Millimeter-scale selective amplification in the developing visual cortex "cortical networks are preferentially activated by inputs aligned to endogenous recurrent subnetworks" in the immature ferret visual cortex. www.biorxiv.org/content/10.6...

New paper (with lots of cute animal videos!) Ever watch your dog "run" while asleep and wonder what’s going on in their brain? In Current Bio we suggest that those twitches aren't just leaky dreams—they’re a vital maintenance system for the most precise movements www.cell.com/current-biol...

REM-sleep twitching in adults and the maintenance of specialized sensorimotor systems

Blumberg et al. present video evidence of twitching during adult sleep in a diverse sample of animals. Adult twitching appears to selectively involve appendages used for active sensing, mirroring thei...

cell.com

Wanna do neuroscience in Paris but can't find interesting lab? Want to come do a sabbatical but don't know who to collaborate? Check this webpage aggregating ~all the neuroscience labs (+200) in Paris. ⚠️only the information of 'verified' profiles is reliable⚠️ Please retweet 🙏 parisneuro.fr

Full online version of our AnkG E35a paper is finally out! E35a is a microexon highly included in GABAergic neurons. Surprisingly, deleting E35a increases their excitability and Ca²⁺ activity without AIS changes, pointing instead to disruption of intracellular Ca²⁺. www.nature.com/articles/s41...

A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability - Nature Communications

Here researchers reveal a microexon in the Ank3 gene encoding Ankyrin G allows cortical interneurons to fine-tune calcium signaling and firing, revealing the contribution of alternative splicing to th...

nature.com

The subiculum: cell-type-specific composition, computation, and function: www.cell.com/trends/neuro... "The subiculum, the primary hippocampal output region, exhibits rich excitatory neuron diversity that contributes to organizing information flow to downstream brain regions."

Youthful antics predict lifespan? Using machine learning & continuous recordings of #killifish behavior from adolescence until death, @brunetlab.bsky.social & @deisseroth.bsky.social find early-life behavior predicted future lifespan! Now published @science.org: www.science.org/doi/10.1126/... 🧪 1/2

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation elifesciences.org/reviewed-pre...

New blog post: Resources for faculty job applications and starting a new lab Suggestions are welcome! spikesandbursts.wordpress.com/2026/03/15/r...

Resources for faculty job applications and starting a new lab

I will soon hit the academic job market, and hopefully not be crushed by it (the academic job market is tough!) Fortunately, there are now fantastic resources from researchers and institutions that…

spikesandbursts.wordpress.com

Take a look at the new "Python4Neuro_2026" notebooks with basic tutorials and exercises for patch-clamp and two-photon calcium imaging analysis in Python. You can launch the notebooks in Google Colab using the links in the README. github.com/dav1dcg/neur...

GitHub - dav1dcg/neuro-notebook-templates: Jupyter notebook templates for processing and analyzing neuroscience data.

Jupyter notebook templates for processing and analyzing neuroscience data. - dav1dcg/neuro-notebook-templates

github.com

If you like AnkG and alternative splicing, check out how this newly identified Ank3 microexon mainly affects GABAergic neurons’ excitability without altering the AIS! Sincerely happy to have been part of this collaborative project captained by Chaolin Zhang! www.nature.com/articles/s41...

A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1-/y mice "...show in males with fragile X syndrome (FXS) that alpha oscillations in humans and alpha-like oscillations in the visual cortex of Fmr1-/y mice are slowed..." www.nature.com/articles/s41...

A human electrophysiological signature of Fragile X pathophysiology is shared in V1 of Fmr1-/y mice - Nature Communications

Kornfeld-Sylla et al reveal how alpha brainwaves are altered in children and adults with Fragile X Syndrome (FXS) and find parallel changes in alpha-like rhythms in juvenile and adult FXS model mice, ...

nature.com

Triggering action potentials of a single neuron by multiphoton excitation elicits visually guided behavior "disruption of a single neuron within the ensemble temporarily paralyzes the entire ensemble and suspends behavioral responses to visual stimuli" www.nature.com/articles/s41...

Visual experience exerts an instructive role on cortical feedback inputs to the primary visual cortex: doi.org/10.1016/j.cu... Dual color 2P to measure the tuning properties and retinotopic organization of inputs from the LM visual area in L1 of V1 in mice reared wearing goggles

🔬🧠 Releasing the 1.0 version of #Suite2p and THE PAPER w/ @marius10p.bsky.social! Now with GPU acceleration. Want to use Suite2p but don’t have 100,000 neuron recordings? We show you how to get those with a standard 2p microscope #neuroscience #imaging #neuroAI www.biorxiv.org/content/10.6...

🚨 new work from the lab on how eye movements 👀 versus orofacial movements influence 🐭 visual cortex activity 🧠 #neuroscience #behavior #neuroAI

Atika Syeda@atika-syeda.bsky.social · 6mo ago

Excited to share “Orofacial behaviors, not eye movements, govern neural activity in mouse visual cortex” www.biorxiv.org/content/10.6... Summary below...