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Saori Abe

@oriabe114.bsky.social

Rheumatologist🇯🇵→🇳🇱 MD, PhD👩‍⚕️mom 👦👧 📖Sjogren’s, Lupus, APS, reproductive health, translational research❤︎

315 Posts557 Follower770 Folgt
Saori Abe@oriabe114.bsky.social · 7mo ago

www.science.org/doi/10.1126/... “DCs from patients with systemic #lupus erythematosus that have variants in the ETV3 gene previously linked to the disease had lower expression of ETV3 compared with DCs from individuals that did not carry the allele. “

Transcription factor Etv3 controls the tolerogenic function of dendritic cells

Dendritic cells (DCs) facilitate the maintenance of immunological tolerance in the steady state. We report that transcription factor Etv3 is preferentially expressed in mature DCs, including tissue-de...

science.org

Saori Abe@oriabe114.bsky.social · 8mo ago

📖 “•Naive myelin-reactive B cells enter the brain and capture antigen •B cells capturing antigen in the brain die by activation-induced cell death •EBV protein LMP1 can rescue B cells from activation-induced cell death •B cells rescued after antigen capture induce MS-like lesions” #Bcell #Antigen

Myelin antigen capture in the CNS by B cells expressing EBV latent membrane protein 1 leads to demyelinating lesion formation

Myelin-reactive B cells entering the central nervous system capture cognate antigen from the parenchyma. Without T cell help, they rapidly die; however, Epstein-Barr virus LMP1 enables them to bypass ...

cell.com

Waggoner Lab@labwaggoner.bsky.social · 8mo ago

Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis www.nature.com/articles/s41... @natimmunol.nature.com @harvardmed.bsky.social @flindersuniversity.bsky.social

Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis - Nature Immunology

Wei et al. perform spatial transcriptomic profiling on synovial tissue biopsy samples from individuals with recent-onset rheumatoid arthritis, finding TGFβ signaling and fibrogenic fibroblast activati...

nature.com

Saori Abe@oriabe114.bsky.social · 8mo ago

www.jnj.com/media-center... 📝Johnson & Johnson unveils new data showing nipocalimab is the first and only investigational FcRn blocker with potential to reduce systemic lupus erythematosus (SLE) activity in a Phase 2 study. #SLE #phase2

Johnson & Johnson unveils new data showing nipocalimab is the first and only investigational FcRn blocker with potential to reduce systemic lupus erythematosus (SLE) activity in a Phase 2 study

The JASMINE study met the primary endpoint and key secondary and exploratory endpoints, including those indicating the potential of nipocalimab for steroid sparing SLE is one of the most prevalent and...

jnj.com

Saori Abe@oriabe114.bsky.social · 9mo ago

Happy New Year 🎉 The last few weeks have been very chaotic as I prepared my move to the Netherlands 🛫🇳🇱. I’m very grateful for my new environment now and hope I can work hard on my new research project ☺️🔥 Let’s go, 2026 ✨

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Saori Abe@oriabe114.bsky.social · 10mo ago

www.science.org/doi/10.1126/... 📖”This marks a critical point in B cell fate commitment, whereby CD21 down-regulation initiates EF B cell proliferation and differentiation, driving the rapid production of ASCs. “ #Bcell #SLE #lupus

CD21 primes extrafollicular differentiation of autoreactive B cells in a TLR7-driven lupus model

CD21 initiates extrafollicular differentiation of autoantibody-secreting cells in an SLE model driven by TLR7 signaling.

science.org

Saori Abe@oriabe114.bsky.social · 10mo ago

www.nature.com/articles/s41... 📖 “Distinct autoreactive CD19– plasma cell subsets accumulate in lupus-prone mice” #SLE #lupus #Bcell

Distinct autoreactive CD19– plasma cell subsets accumulate in lupus-prone mice - Nature Communications

Plasma cells (PC) contribute to the pathogenesis of autoimmune diseases by secreting autoantibodies. Strategies to target pathogenic PCs are thus required. Here, the authors profile different PC subse...

nature.com

Saori Abe@oriabe114.bsky.social · 10mo ago

www.science.org/doi/10.1126/... “These EBV-infected B cells with antigen-presenting abilities had the capacity to activate autoreactive helper T cells, setting off a chain reaction where those T cells could activate other autoreactive B cells, including uninfected ones.” #SLE #Bcell #EBV

Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells in systemic lupus erythematosus

Epstein-Barr virus reprograms autoreactive B cells as antigen-presenting cells to promote pathogenic antinuclear T and B cell responses in lupus.

science.org

Saori Abe@oriabe114.bsky.social · 10mo ago

www.science.org/doi/10.1126/... “RA is characterized by pathological fibroblast-like synoviocytes (FLSs)... To address this, Huang et al. focused on the role of small nucleolar RNA, C/D box 3 (SNORD3), which is up-regulated by inflammatory modulators that are important in RA models.” #arthritis

snoRNA Snord3 promotes rheumatoid arthritis by epigenetic regulation of ESM1 in fibroblast-like synoviocytes in mice

snoRNA Snord3-mediated epigenetic activation of ESM1 is a potential therapeutic target in rheumatoid arthritis.

science.org

Saori Abe@oriabe114.bsky.social · 11mo ago

www.science.org/doi/10.1126/... 📖”Through a lineage-tracing approach, they detected conversion of synovial TH17 cells to CD44+ IFN-γ−IL-10− exTH17 cells, which are arthritogenic and cause joint inflammation independent of IL-17. “ #Th17 #arthritis

TH17 cells converted into exTH17 cells sustain rheumatoid-like IL-17–independent inflammatory arthritis

ExTH17 cells drive IL-17–independent chronic SKG arthritis in mice through up-regulation of CD44 and S1PR4 and cross-talk with FLS.

science.org

Saori Abe@oriabe114.bsky.social · 11mo ago

www.cell.com/immunity/abs... 📖 Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development #Tfh #germinalcenter

Highly functional and prolonged germinal center T follicular helper cell responses are associated with enhanced neutralizing antibody development

The dynamics of antigen-specific Tfh responses during extended germinal center reactions are not well characterized. Marina-Zárate et al. show that vaccine-specific Tfh cells in the lymph node undergo...

cell.com

Saori Abe@oriabe114.bsky.social · 11mo ago

www.thelancet.com/journals/lan... 👉”Fc receptor blockade by nipocalimab 15 mg/kg significantly improved clinical disease activity versus placebo and was safe and well tolerated in participants with moderate-to-severe, active Sjögren's disease.” #Sjogren #PhaseII

Efficacy and safety of nipocalimab in patients with moderate-to-severe Sjögren's disease (DAHLIAS): a randomised, phase 2, placebo-controlled, double-blind trial

Fc receptor blockade by nipocalimab 15 mg/kg significantly improved clinical disease activity versus placebo and was safe and well tolerated in participants with moderate-to-severe, active Sjögren's d...

thelancet.com

Saori Abe@oriabe114.bsky.social · 11mo ago

www.nature.com/articles/s41... 📖 “The exonuclease PLD4 helps restrain activation of TLR7 and TLR9 by cleaving their ligands. …identified loss-of-function variants in PLD4 in five patients with #SLE, linking disruption of this regulatory mechanism with systemic inflammation and #autoimmunity.”

PLD4 variants promote SLE via unchecked TLR activation - Nature Reviews Rheumatology

Biallelic loss-of-function mutations in PLD4, as identified in five patients with SLE, lead to Toll-like receptor-driven hyperactivation of type I interferon, immune cell expansion and autoimmunity.

nature.com