Osvaldo Contreras
@osvaldoics.bsky.social
Cell Identity + Cell Cycle Networks + Chromatin Dynamics & DevEvo in Human Development 🧬 @UNSWMedicine | #MyoTwitter 📝 @Prelights #eLifeAmbassador
Thanks for highlighting our most recent paper 📝
Computational and Structural Biotechnology Journal (CSBJ)@csbj.org · 6d ago🔗 A Scalable MNase-seq Framework for Reproducible Nucleosome Profiling across Pluripotent Stem Cell and Cardiomyocyte Models. doi.org/10.34133/csb... 📚 CSBJ - A Science Partner Journal: spj.science.org/journal/csbj @victorchang.edu.au @csbj.org @spjournals.bsky.social @aaas.org #ChromatinBiology
🫀 First successful nucleosome footprinting in cardiomyocytes and end-to-end MNase-seq framework, to our knowledge. Our MNase-seq tracks nucleosome organisatio in pluripotent stem cells at base-pair resolution. 🧬 (1/3)
Kudos to @science.org for this self-analysis of the peer review process. These kind of data are never shared and don't have to be. Wildly refreshing to see it out in the open. Editorial and peer review dynamics at elite general science journals | Science Advances www.science.org/doi/10.1126/...
Editorial and peer review dynamics at elite general science journals
Analyses of deidentified data reveal complex interactions that quantify success at elite general science journals.
science.org
🫀 First successful nucleosome footprinting in cardiomyocytes and end-to-end MNase-seq framework, to our knowledge. Our MNase-seq tracks nucleosome organisatio in pluripotent stem cells at base-pair resolution. 🧬 (1/3)
The qed 1% club controversy highlights a difficult road ahead for openRxiv as they embark on the next decade of trying to bring about a bigger preprint ecosystem. But it also raises questions about the motivations of some open science "advocates"
The 1% club and the rocky road ahead for bioRxiv
The recent launch of qed's "top 1%" preprint ranking has sparked controversy, with concerns about its arbitrary nature, potential harm to authors, and low-quality inclusions. While the tool aims to provide valuable feedback, backlash against qed and its partnership with bioRxiv highlights the challenges and complexities within the evolving preprint landscape and academic community.
ripplingideas.org
Delighted to share a new preprint from the lab: Fat1 deletion enhances Fibro-Adipogenic Differentiation and Adipogenic expansion following injury in skeletal muscle doi.org/10.64898/202... #Myoblue #FAPs #IMAT #muscleregeneration #adipogenesis #skeletalmuscle
📖New preprint from my team🤩 A scalable MNase-seq framework for reproducible nucleosome profiling across pluripotent stem cell and cardiomyocyte models A data-driven project where we’ve provided the code of nucleosome dynamics and footprinting @victorchang.edu.au www.biorxiv.org/content/10.6...
A scalable MNase-seq framework for reproducible nucleosome profiling across pluripotent stem cell and cardiomyocyte models
Micrococcal nuclease (MNase) digestion is widely used to profile chromatin accessibility and nucleosome footprinting. However, its application is often limited by sensitivity to reaction conditions, h...
biorxiv.org
☀️ Join us this week for another great Eastern VGZT session! 🗓️ Wednesday, June 10th ⏰ 9:00 BST / 10:00 CEST / 13:30 IST / 17:00 JST / 18:00 AEST Our speakers are: 👉 Ksenia Skvortsova (@kseskv.bsky.social) 👉 Osvaldo Contreras (@osvaldoics.bsky.social) See you there! 👋
Congratulations @osvaldoics.bsky.social on being awarded a MAWA/RFF Research Grant - supporting his project Animal Free Human Stem Cell Models to Investigate Congenital Heart Defects. Grateful to the MAWA Trust and the Rozzoli Family Fund for supporting this work.
ICYMI 🔗: www.biorxiv.org/content/10.6...
Osvaldo Contreras@osvaldoics.bsky.social · 8mo agoI’m back here to share our new pre-print! 🔬 🧬 😃 Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia Flow cytometry+Imaging+RNA-seq+Proteomics Preprint available on bioRxiv [link in comments]
I’m back here to share our new pre-print! 🔬 🧬 😃 Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia Flow cytometry+Imaging+RNA-seq+Proteomics Preprint available on bioRxiv [link in comments]
Fantastic insights on how replication stress drives cell differentiation by Osvaldo Contreras at the joint meeting of the #InSDB and International Society of Differentiation #ISD joint meeting at #IISER_BERHAMPUR @osvaldoics.bsky.social #INSDBISD2025
Star #Scientist @osvaldoics.bsky.socia is uncovering how hearts grow - and what goes wrong when they don’t. He's mapping the molecular ‘blueprint’ of heart cells to uncover the mechanisms that could one day help damaged hearts repair themselves:
Star Scientist - Dr Osvaldo Contreras
The Institute's Dr Osvaldo Contreras's work could one day help children born with heart defects and adults facing heart failure live longer, healthier…
victorchang.edu.au
New @natcomms.nature.com paper today from Tracy Bryan's lab @cmri.bsky.social: "Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase". Happy our lab could play a small part. Congrats Tracy, Ash Harman, Noa Lamm and the whole team. www.nature.com/articles/s41...
Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase - Nature Communications
Telomerase recruitment to telomeres is a tightly regulated process which is stimulated by replication stress. Here, the authors identify that nuclear filamentous actin is important for interaction bet...
nature.com
💡Dr Osvaldo Contreras’s funds will allow for open access publication of “OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics” in iScience.
“There were some cells in there that were very messed up” In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man go.nature.com/44yj4MN
We are all mosaics: vast genetic diversity found between cells in a single person
Technical advances allow researchers to trace the genetic changes that occur over time.
go.nature.com
In vivo differentiation of embryonic cells devoid of key reprogramming factors
In vivo differentiation of embryonic cells devoid of key reprogramming factors
Youlten, Miao et al. use zebrafish transplantation to understand the fate of cells lacking pluripotency factors Nanog, Pou5f3, and Sox19b (NPS) in developmental reprogramming and cell identity establishment. They found that NPS are required for proper cell identity for most, but not all, lineages, likely through nuclear and cytoplasmic reprogramming.
dlvr.it
One week left to register! Join the Editors-in-Chief of Differentiation on November 14 at 12:00 p.m. Central for a virtual seminar with Pavani P. Perera on the enteric nervous system, evolution, and cave fish. Register for free: https://bit.ly/4oaU71P Topic: https://bit.ly/478UZhu
Save the date! @isscr.org, @alleninstitute.org & @socdevbio.bsky.social are collaborating to present a 3-day scientific symposium led by early-career scientists. The Stem Cell & Developmental Biology Early Career Symposium will be held September 23-25, 2026 in Seattle, WA. Learn more: bit.ly/4p98dkv
Catch up on the recordings from our October #DevPres webinar on development across scales. View the presentations from @osvaldoics.bsky.social and @yinanwan.bsky.social. thenode.biologists.com/catch-up-on-...
Catch up on Development presents… webinar on development across scales - the Node
Our October webinar featured two early-career researchers working on development across scales. Here, we share the talks from Osvaldo Contreras (Victor
thenode.biologists.com
Transitions is the newest in our series of stem cell conversations. Launched by Ritika Saxena, Jarmon Lees and @osvaldoics.bsky.social we explore project and career transitions. All the parts needed for successful science that don't make it to the bench. For Aussie scientists, but all welcome.
We are celebrating 5 years of the Australia stem cell conversation! Hosted by @unimelb.bsky.social and @asscr.bsky.social the stem cell conversation is a weekly 30min virtual seminar series organised by EMCR for EMCR. Join the first 'transitions' episode Leadership through Service: 11am AEST Wed.
I’m very excited to be invited to present at “Development Presents…” Thanks @amjeve.bsky.social
the Node@the-node.bsky.social · 11mo agoJoin us 15 October to hear from two early-career researchers, @osvaldoics.bsky.social & Yinan Wan, working on development across scales. Chaired by @dev-journal.bsky.social Executive Editor @amjeve.bsky.social. 📅 15 October, 09:00 BST (UTC+1) Register here: us02web.zoom.us/webinar/regi...
Remarkable conference organized by @asbmbaus.bsky.social up in Brisbane at the University of Queensland. I was invited to present my latest work as a Keynote Speaker for the Multi-Sonic’s session, and so many thanks for selecting me! Truly an honour!
SAVE THE DATE! Join us for the 2025 @anzscdb.bsky.social NSW Branch Cell & Developmental Biology Symposium at the Garvan Institute @garvaninstitute.bsky.social on Wed 5 Nov 2025. Keynote speakers include Dougall Norris, @katequinlan.bsky.social, Silvia Velasco and @ryanlister.bsky.social 🔬🧠🧫
Honored to present at @ramacgenomics.bsky.social @unsw.edu.au next Tuesday.😃
Martin Smith@martinalexsmith.bsky.social · 12mo agoSome exciting #SingleCell events with #ParseBio coming up this month at @ramacgenomics.bsky.social 🧬 9 Sept: SPLiT-Seq Tech Showcase Seminar 🔗 tinyurl.com/bddc5zc3 15 Sept: Application deadline for discounted Parse Evercode WT Mini v3 Kit promotion 🔗 tinyurl.com/yc84zmfm 📩 ramaciotti@unsw.edu.au
Don't miss @osvaldoics.bsky.social in the flesh next Tuesday in Sydney
Martin Smith@martinalexsmith.bsky.social · 12mo agoSome exciting #SingleCell events with #ParseBio coming up this month at @ramacgenomics.bsky.social 🧬 9 Sept: SPLiT-Seq Tech Showcase Seminar 🔗 tinyurl.com/bddc5zc3 15 Sept: Application deadline for discounted Parse Evercode WT Mini v3 Kit promotion 🔗 tinyurl.com/yc84zmfm 📩 ramaciotti@unsw.edu.au
We're proud to share Dr Osvaldo Contreras has been awarded a Scale Biosciences Core Lab Grant, from @garvaninstitute.bsky.social Genomics Platform, Scale Biosciences, and Integrated Sciences to further his research into the origins of congenital heart disease that affects one in 100 babies.
Thrilled to share our new paper: "OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics"! We've developed a new resource that make this crucial research more accessible, accurate, powerful and low-cost. www.cell.com/iscience/ful...
OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics
Biochemistry; Cell biology; Developmental biology; Computational bioinformatics
cell.com
