Timothée Bruel
@timotheebruel.bsky.social
Group Leader / Antiviral Activities of Antibodies @Virus_Immunity @institutpasteur - Virology/Immunology - Member @SFV_France
Complement augments antibody neutralization of SARS-CoV-2 variants www.science.org/doi/10.1126/...
Complement augments antibody neutralization of SARS-CoV-2 variants
Complement C1q and C3 potentiate neutralization activity of anti-S2 antibodies against SARS-CoV-2 variants via the Fc region.
science.org
Institut Pasteur 93 participants found complement made existing antibodies much better at neutralizing newer SARS-CoV-2 variants. It boosted conserved S2 antibodies by coating the virus with C3 instead of bursting it. www.science.org/doi/10.1126/...
Complement augments antibody neutralization of SARS-CoV-2 variants
Complement C1q and C3 potentiate neutralization activity of anti-S2 antibodies against SARS-CoV-2 variants via the Fc region.
science.org
🔬 New paper in Science Translational Medicine! @science.org The complement system boosts antibody neutralization of SARS-CoV-2, especially vs immune-evasive variants. Anti-S2 antibodies + complement = better survival in severe COVID-19. 🦠🛡️ www.science.org/doi/full/10.... @martin-jg.bsky.social
Complement augments antibody neutralization of SARS-CoV-2 variants
Complement C1q and C3 potentiate neutralization activity of anti-S2 antibodies against SARS-CoV-2 variants via the Fc region.
science.org
🔬 New paper in Science Translational Medicine! @science.org The complement system boosts antibody neutralization of SARS-CoV-2, especially vs immune-evasive variants. Anti-S2 antibodies + complement = better survival in severe COVID-19. 🦠🛡️ www.science.org/doi/full/10.... @martin-jg.bsky.social
Complement augments antibody neutralization of SARS-CoV-2 variants
Complement C1q and C3 potentiate neutralization activity of anti-S2 antibodies against SARS-CoV-2 variants via the Fc region.
science.org
Institut Pasteur researchers review how viruses hijack host proteases to weaken antibodies. Instead of mutating, viruses shed decoy proteins, hide key epitopes, or blunt Fc and complement functions, quietly undermining neutralization. journals.asm.org/doi/10.1128/...
Impact of cellular proteases on the function of antiviral antibodies | Journal of Virology
Viruses and their hosts have been co-evolving in a continual arms race for fitness and survival, respectively (1). In humans, the innate and adaptive arms of immunity intimately interact to control infection. Antibodies (Abs), secreted by certain activated B cells, are an essential portion of the adaptive immune response and are a major pillar in the viral clearance of both enveloped viruses as well as some non-enveloped viruses (1–5). Certain antibodies are developed with the ability, through their fragment antigen-binding region, to bind to viral epitopes and, through a variety of methods (e.g., steric obstruction or changing conformation), result in the neutralization of the target antigen (4).
journals.asm.org
Complement C1q and C3 potentiate neutralization activity of anti-S2 antibodies against SARS-CoV-2 variants via the Fc region www.science.org/doi/10.1126/... @institutpasteur.bsky.social
The Bundibugyo virus outbreak in the DRC and Uganda has focused concern on potential countermeasures. Investigators assessed cross-reactive immune responses in serum obtained during previous Ebola vaccine trials. Learn more: https://nej.md/4b67kVe
🎓 Huge congrats to Dr.Jungbaueur-Groznica, my very first PhD student! 🧪 His work shows how the classical complement pathway, via S2-targeting antibodies, boosts SARS-CoV-2 neutralisation 🛡️ Bravo Martin! 🚀 @pasteur.fr @virusimmunitylab.bsky.social @roumenina.bsky.social@spyroslytras.bsky.social
🦠💡 Bacteria have millions of secret weapons against viruses! Researchers used AI to uncover millions of new bacterial proteins likely involved in antiviral defense — suggesting immunity genes make up ~1.5% of the genome, 3× more than thought. 🔗 www.pasteur.fr/en/research-... @audeber.bsky.social
Bacteria Have Millions of Secret Weapons Against Viruses
Millions of new proteins with predicted roles in defence against viruses have been identified in bacteria. It was thought that around 0.5% of the average bacterial genome had some involvement in immun...
pasteur.fr
🦠 New preprint! We detect and profile individual SARS-CoV-2 particles by flow virometry, directly from cultures & patient swabs, no purification needed. Opens new doors for viral heterogeneity & diagnostics. 📄 www.medrxiv.org/content/10.6...
Detection and characterization of single SARS-CoV-2 viral particles by flow virometry
Virus infected cells release viral particles, which have variable protein content and are functionally diverse. Deciphering this heterogeneity remains a challenge. Here, we adapt flow virometry to det...
medrxiv.org
🚀 New review out! How viruses hijack host proteases to evade antibodies: shedding decoys, reshaping antigens & cutting Fc-effector pathways. 👉 journals.asm.org/doi/10.1128/... #Virology #Immunology
Impact of cellular proteases on the function of antiviral antibodies | Journal of Virology
Viruses and their hosts have been co-evolving in a continual arms race for fitness and survival, respectively (1). In humans, the innate and adaptive arms of immunity intimately interact to control in...
journals.asm.org
Keratinocyte VISTA attenuates UV light-induced skin injury by suppressing cutaneous type I interferon (IFN-I) response https://www.biorxiv.org/content/10.64898/2025.12.04.692370v1
Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir https://www.biorxiv.org/content/10.64898/2025.12.07.692769v1
Spike conformational and glycan heterogeneity associated with furin cleavage causes incomplete neutralization of SARS-CoV-2 www.nature.com/articles/s41...
Spike conformational and glycan heterogeneity associated with furin cleavage causes incomplete neutralization of SARS-CoV-2 - Nature Communications
The tightly closed conformation of the Spike helps SARS-CoV-2 evade the immune system. This cryptic conformation is shaped by increased mannosidic glycosylation and furin cleavage shielding conformati...
nature.com
Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice www.science.org/doi/10.1126/...
Eliminating interactions with the viral Fc receptor improves antibody-mediated protection against neonatal HSV infection in mice
HSV-specific antibodies demonstrate improved activity in vitro and in vivo when the IgG Fc domain is rendered insensitive to the viral Fc receptor.
science.org
Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions journals.asm.org/doi/10.1128/...
Human antibody targeting of coronavirus spike S2 subunit is associated with protection mediated by Fc effector functions | Journal of Virology
Bats and pangolins are natural reservoirs of betacoronaviruses (β-CoVs) and continue to pose a significant risk for future outbreaks through zoonotic transmissions. This highlights the need for effect...
journals.asm.org
Effects and mechanisms of monoclonal and polyclonal human antibodies in protection of humanized mice from HIV-1 challenge https://www.biorxiv.org/content/10.1101/2025.11.12.688003v1
The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling @natcomms.nature.com www.nature.com/articles/s41...
Our latest work on #COVID immunity and imprinting in humans. Led by Ale Tortorici and Kaiti Sprouse with @aminaddetia.bsky.social and several others! www.biorxiv.org/content/10.1...
Repeated COVID-19 vaccine boosters elicit variant-specific memory B cells in humans
The first exposure to a pathogen or an antigen profoundly impacts immune responses upon subsequent encounter with related pathogens. This immune imprinting explains that infection or vaccination with ...
biorxiv.org
Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding journals.plos.org/plospathogen...
Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding
Author summary Recent epidemic-causing coronaviruses, including SARS-CoV-2, originated in bats. Large numbers of such viruses circulate in bats and pose clear and present risks to humans. However, our...
journals.plos.org
« A lineage that is virtually unchanged since 1976 challenges assumptions about Ebola's evolution and exposes the blind spots of surveillance. »
Ebola virus in Kasai revives 50-year-old questions on viral latency www.thelancet.com/journals/lan...
#NewResearch Dipeptidase 1 is a functional receptor for a porcine coronavirus @virusfusion007.bsky.social @jeremydufloo.bsky.social #microsky www.nature.com/articles/s41...
Client Challenge
nature.com
Dipeptidase 1 is a functional receptor for a porcine coronavirus www.nature.com/articles/s41...
Dipeptidase 1 is a functional receptor for a porcine coronavirus - Nature Microbiology
Characterization of dipeptidase 1 as a receptor for porcine haemagglutinating encephalomyelitis virus reveals the versatility of embecovirus receptor binding domains and receptor usage.
nature.com
« Our findings strongly implicate VZV reactivation as a modifiable risk factor for dementia. » www.nature.com/articles/s41...
Varicella-zoster virus reactivation and the risk of dementia - Nature Medicine
Large-scale longitudinal health records reveal consistent association of varicella-zoster virus reactivation with dementia.
nature.com
Re-infection with SARS-CoV-2 is associated with increased antibody breadth and potency against diverse sarbecovirus strains https://www.biorxiv.org/content/10.1101/2025.10.03.679858v1
After years in the making, Joe McKellar @viroscope.bsky.social’s final PhD paper is finally out today in PNAS! 🎉 🎉🎉 www.pnas.org/doi/10.1073/...
Human MX1 orchestrates the cytoplasmic sequestration of neosynthesized influenza A virus vRNPs | PNAS
Interferon-inducible Myxovirus resistance 1 (MX1) proteins are known to restrict influenza A virus (IAV) transcription/replication process. Herein,...
pnas.org
New paper (micro) from our lab : “No evidence for human or rodent deltavirus replication in yeast”. A collaboration with Dom helmlinger’s lab .
No evidence for human or rodent deltavirus replication in yeast | microPublication
doi.org
Read the associated research article here: www.nature.com/articles/s41...
Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor - Nature Microbiology
A genome-wide CRISPR screen helps to identify the Epstein–Barr virus receptor desmocollin 2 for primary epithelial cell infection. Additional infection assays revealed that desmocollin 3 also aids infection.
nature.com
Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor @natmicrobiol.nature.com Microbiol www.nature.com/articles/s41...
Epstein–Barr virus exploits desmocollin 2 as the principal epithelial cell entry receptor - Nature Microbiology
A genome-wide CRISPR screen helps to identify the Epstein–Barr virus receptor desmocollin 2 for primary epithelial cell infection. Additional infection assays revealed that desmocollin 3 also aids infection.
nature.com